A Review on Transdermal Patches Used as an Anti-Inflammatory Agent

CHOUDHURY, DEIJY; Dutta, Koushik; Kalita, Ramen

doi:10.22159/ajpcr.2021.v14i12.43277

Cited by 8 publications

(5 citation statements)

References 73 publications

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“…The films are removed by sliding a sharp blade along the film's edges and then pulling the blade out. 9,10 Modern Techniques for Transdermal Drug Delivery System Different methodologies have been developed to enhance transder mal dr ug absor ption, including per meation enhancement through iontophoresis, electroporation, ultrasound etc.…”

Section: Methods Of Preparing Transdermal Patchesmentioning

confidence: 99%

Overview of Antihypertensive Transdermal Drug Delivery System

Bidkar,

Tandale,

Meher

et al. 2023

IJDDT

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In order to boost bioavailability and enhance patient compliance, this review focuses on the antihypertensive action of transdermal patches. Using a transdermal method for administering medication (TDDS), it is possible to administer a systemic medicament via a simple skin patch. Among the most prevalent human diseases is hypertension. There is a strong correlation between hypertension and cardiovascular mortality and morbidity. The evolution of skin science, innovation, and experience that led to these patches began with the earliest written records of human history and continues to this day through with a combination of trial and error, clinical observation, and research evidence. Because it’s a long-term condition, treatment will take a while

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Section: Methods Of Preparing Transdermal Patchesmentioning

confidence: 99%

Overview of Antihypertensive Transdermal Drug Delivery System

Bidkar,

Tandale,

Meher

et al. 2023

IJDDT

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show abstract

“…The results from the OFAT trials were then used to further fine-tune the formulations using Box-Behnken design, a quality by design (QbD) approach used for optimization. By first identifying the concentration ranges of each polymer that could produce adequate patches, these ranges could be refined and the interactions between polymers could be explored using the Box-Behnken design to generate an optimized formulation [9,10]. To prepare the polymeric solution, HPMC 50 cps or ethyl cellulose was dissolved in 50 ml methanol.…”

Section: Trial Runsmentioning

confidence: 99%

Design, Development, and Evaluation of Transdermal Patches Containing Memantine Hydrochloride

VALEVETI,

PASHIKANTI

2023

Int J App Pharm

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Objective: This study aimed to develop an effective transdermal drug delivery system of memantine hydrochloride (MH), an anti-Alzheimer's drug, to improve patient compliance and optimize drug therapy in patients with dementia who often have difficulties adhering to oral medication schedules. Methods: Various transdermal patches of MH were prepared using the box-Behnken design of experiments with different polymer combinations. The fabricated patches were evaluated for properties like thickness, folding endurance, drug content uniformity, in vitro drug release, and diffusion studies. An optimal formulation was selected based on the results and further studied for pharmacokinetic parameters in rabbits. The results were compared to conventional tablets containing the same polymer combination. Results: Formulation B2 containing Hydroxy Propyl Methyl Cellulose (HPMC) 137.5 mg, Ethyl Cellulose (EC) 400 mg, and xanthan gum 300 mg had a flux of 212.24 μg/cm2/h, the permeability of 2.32 cm/h, and 27.95% release at 8h, with first-order and non-Fickian drug release kinetics. It was non-irritating, and in vitro release studies showed sustained release for up to 48 h. In vivo studies in rabbits also indicated superior drug absorption and sustained release from the patches compared to tablets. Conclusion: The optimized transdermal patch formulation had the potential to provide a prolonged release of MH for over 2 d and reduce the frequency of dosing. However, further studies are warranted to confirm the efficacy, safety, and pharmacokinetics of the patches in human models before clinical use.

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“…The anti-inflammatory effect of selected optimized transdermal formulation was determined using carrageenan -induced paw edema in male rat [19][20][21] . The rats were divided into two groups (6 mice in each group).…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Development, characterization and in VIVO evaluation of diffusion controlled transdermal matrix patches of a model anti-Inflammatory drug

Kapoor¹,

Bhatt²,

Bilandi³

et al. 2022

ijhs

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In the current research, diffusion controlled transdermal matrix patches of Lornoxicam, an anti-inflammatory drug was developed by solvent casting method using hydrophilic and hydrophobic polymers in different ratios and tween-80 and span-80 as permeation enhancers. Formulated patches were characterized for different physicochemical parameters in terms of moisture loss, drug content, film thickness and strength, uptake and loss of moisture, transmission of water vapor etc. All of these parameters were found be satisfactory. In-vitro diffusion studies of formulated patches were performed by using Franz diffusion cells. The drug diffusion rate followed zero order kinetics with super case II transport diffusion. Based on In-vitro diffusion data, best formulation was selected and used further for the stability analysis. Developed patches were stable at different temperature and humidity settings in terms of physicochemical properties and drug content. The optimized patches were also evaluated for the in-vivoanti-inflammatory and analgesic activity using suitable animal models. The results of all the in-vitro and in-vivo studies justify the selection of transdermal route for the systemic delivery of Lornoxicam to overcome its shortcomings when administered orally.

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A Review on Transdermal Patches Used as an Anti-Inflammatory Agent

Cited by 8 publications

References 73 publications

Overview of Antihypertensive Transdermal Drug Delivery System

Overview of Antihypertensive Transdermal Drug Delivery System

Design, Development, and Evaluation of Transdermal Patches Containing Memantine Hydrochloride

Development, characterization and in VIVO evaluation of diffusion controlled transdermal matrix patches of a model anti-Inflammatory drug

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