Comparison of Racemic Ketamine Versus (S+) Ketamine When Combined with Midazolam for Anesthesia of Callithrix jacchus and Callithrix penicillata

Furtado, Mariana Malzoni; Nunes, Adauto Luís Veloso; Intelizano, Tatiana Regina; Teixeira, Rodrigo Hidalgo Ferreira; Cortopassi, Silvia Renata Gaído

doi:10.1638/2008-0016.1

Cited by 17 publications

(23 citation statements)

References 22 publications

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“…In that study, the first combination had less of an effect on RR than the second. In addition, Furtado et al (2010) found similar results in monkeys of the genus Callithrix, reporting a decrease of RR with similar doses of ketamine and midazolam. The decrease in RR in their study may be related to properties of benzodiazepines as a tranquilizer, sedative, hypnotic, anticonvulsant, and a muscle relaxant.…”

Section: Resultssupporting

confidence: 62%

Different dissociative anesthesia protocols for coatis (Nasua nasua)

Martini

Monzem

Gomes

et al. 2017

AVB

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Article historyThis study evaluated the effects of various combinations of dissociative drugs, tranquilizers, and sedatives in four male coatis (Nasua nasua) with an average age and weight of 4.8 ± 1.3 years and 6.02 ± 0.56 kg, respectively. We studied six groups with different anesthetic protocols: CX (10 mg/kg ketamine-S and 2 mg/kg xylazine); CXA (10 mg/kg ketamine-S, 2 mg/kg xylazine, and 0.04 mg/kg atropine); CM (10 mg/kg ketamine-S and 0.5 mg/kg midazolam); CMAc (10 mg/kg ketamine-S, 0.5 mg/kg of midazolam, and 1 mg/kg acepromazine); C(20)M (20 mg/kg of ketamine-S and 0.5 mg/kg midazolam); and TZ (7 mg/kg of tiletamine and zolazepam), with a 30-day interval between the completion of each procedure. We evaluated heart rate (HR), respiratory rate (RR), saturation of oxyhemoglobin (SpO2), body temperature T (°C), and muscle relaxation, using a scoring system. There was no statistical difference for SpO2. T (°C) was progressively reduced over time in all groups (p< 0.0001). The groups CM, C(20)M, CMAc, and TZ demonstrated the greatest effect on HR and T (°C). With respect to respiratory rate reduction, groups CM and TZ showed similar results. The best degree of muscle relaxation was observed in groups CM and C(20)M. We concluded that the combination of 20 mg/kg ketamine and midazolam 0. 5 mg/kg (group C(20)M) is an option for dissociative anesthesia of coatis, producing smaller changes in T (°C) and HR, and promoting better muscular relaxation when compared to other combinations.

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Section: Resultssupporting

confidence: 62%

Different dissociative anesthesia protocols for coatis (Nasua nasua)

Martini

Monzem

Gomes

et al. 2017

AVB

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“…Hanskins et al (1985) demonstraram diminuição da ƒ e do volume minuto durante aproximadamente 15 minutos em cães anestesiados com cetamina . Furtado et al (2010), encontraram os mesmos resultados em macacos do gênero Callihtrix, verificando diminuição da ƒ com doses similares de cetamina e midazolam. Cabe ressaltar que, no presente estudo, a avaliação dos parâmetros cessava após o fim da sedação, assim alguns animais nos últimos momentos não foram avaliados para evitar maior estresse dos mesmos.…”

Section: Resultsunclassified

“…Embora em humanos o isômero levógiro S(+) da cetamina apresente maior potência e menores efeitos colaterais (Lauretti et al 2000), em cães (Duque et al 2008) e em macacos do gênero Callithrix (Furtado et al 2010) não se observaram diferenças da forma racêmica.…”

Section: Introductionunclassified

Efeitos da associação de tiletamina/zolazepam ou cetamina S(+)/midazolam/tramadol para contenção química em bugios-ruivos (Allouatta guariba clamitans)

et al. 2013

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We used 12 healthy red howler monkeys, weighing 6.4±0.4 kg, which were fasted and without water six and two hours, respectively. The animals were divided into two groups that received intramuscular injection: TZ (n=6) which received tiletamine-zolazepam (Zoletil ® ) at a dose of 3.6mg/kg and CEMTRA (n=6) which received ketamine S (+), tramadol and midazolan (Cemtra ® , pilot batch 001/10, Ouro Fino Saúde Animal Ltda, Cravinhos/SP, Brazil, comprising 100mg/ml of ketamine S (+), tramadol 20mg/ml and 10mg/ml of midazolam) in dose of 1ml of the association for each 10kg of body weight, equivalent doses of 10mg/kg, 1mg/kg and 2mg/kg, respectively. Prior to administration of drugs (M0) were evaluated: heart rate (HR), respiratory rate (RR), rectal temperature (RT), capillary refill time (CRT), systolic arterial pressure (SAP), hemoglobin oxygen saturation (SpO2 ), presence of salivation, degree of muscle relaxation and sedation, Bispectral index (BIS) and Signal Quality BIS (SQI), interdigital pinch response and latency times, ambulation and total recovery (TRT). The parameters were reassessed M5, M10, M20, M30, M40 and M50 (5, 10, 20, 30, 40 and 50 minutes after drug administration). In TZ animals were more responsive to the interdigital pinch over time. The animals of CEMTRA showed a higher degree of muscle relaxation and sedation. The RR of CEMTRA was lower after administration of treatment at all times in relation to M0. Among the groups RR of CEMTRA was lower compared to the TZ in M2 and M4. The total time of sedation and recovery was 48±4 min and 150.1±42.1 for the CEMTRA and 38±7 and 73.1±20.6 for the TZ. We conclude that both formulations are safe for containing chemical howler, and the CEMTRA showed better sedation and muscle relaxant.

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“…Midazolam is used while combined with ketamine in primates, promoting excellent muscle relaxation with few side effects . It can be used to promote light sedation with muscle relaxation, with the objective of reducing stress and facilitating physical restraint, and it does not alter the heart rate (HR) and does not cause arrhythmia .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of three chemical immobilization protocols in golden‐headed lion tamarins (Leontopithecus chrysomelas) undergoing vasectomy surgery

Ferraro

Molina

Catão‐Dias

et al. 2017

J of Medical Primatology

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Heart rate, sedation and muscle relaxation degrees, antinociception, and lidocaine consumption presented significant difference between midazolam and dexmedetomidine groups. Bradycardia was present on dexmedetomidine groups, with values remaining within the normal range. Dexmedetomidine groups present the best outcomes for muscle relaxation, sedation, and antinociception and were safe for vasectomy surgery in golden-headed lion tamarins.

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Comparison of Racemic Ketamine Versus (S+) Ketamine When Combined with Midazolam for Anesthesia of Callithrix jacchus and Callithrix penicillata

Cited by 17 publications

References 22 publications

Different dissociative anesthesia protocols for coatis (Nasua nasua)

Different dissociative anesthesia protocols for coatis (Nasua nasua)

Efeitos da associação de tiletamina/zolazepam ou cetamina S(+)/midazolam/tramadol para contenção química em bugios-ruivos (Allouatta guariba clamitans)

Evaluation of three chemical immobilization protocols in golden‐headed lion tamarins (Leontopithecus chrysomelas) undergoing vasectomy surgery

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