Comparison of pulse and super pulse radiation modes’ singlet oxygen production effect in antimicrobial photodynamic therapy (AmPDT)

Kamanlı, Ali Furkan; Çetinel, Gökçen

doi:10.1016/j.pdpdt.2020.101706

Cited by 4 publications

(2 citation statements)

References 62 publications

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“…Furthermore, X-ray as an activated source can also facilitate the activation of the PDT system by transferring energy harvested from X-ray irradiation to the PS used [485]. Kamanli et al compared pulse and superpulse radiation modes, showing that the latter is more effective to produce 1 O 2 and S. aureus eradication than the former [486].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

et al. 2021

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Antimicrobial photodynamic therapy (aPDT) has become a fundamental tool in modern therapeutics, notably due to the expanding versatility of photosensitizers (PSs) and the numerous possibilities to combine aPDT with other antimicrobial treatments to combat localized infections. After revisiting the basic principles of aPDT, this review first highlights the current state of the art of curative or preventive aPDT applications with relevant clinical trials. In addition, the most recent developments in photochemistry and photophysics as well as advanced carrier systems in the context of aPDT are provided, with a focus on the latest generations of efficient and versatile PSs and the progress towards hybrid-multicomponent systems. In particular, deeper insight into combinatory aPDT approaches is afforded, involving non-radiative or other light-based modalities. Selected aPDT perspectives are outlined, pointing out new strategies to target and treat microorganisms. Finally, the review works out the evolution of the conceptually simple PDT methodology towards a much more sophisticated, integrated, and innovative technology as an important element of potent antimicrobial strategies.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

et al. 2021

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“…The system has three modes to choose from: CW, pulse, and burst pulse. The modes were developed considering the application modalities indicated in the literature [ 23 , 24 ]. The user can select the experiment duration and mode-specific parameters for each mode separately.…”

Section: Methodsmentioning

confidence: 99%

Development of a novel laboratory photodynamic therapy device: automated multi-mode LED system for optimum well-plate irradiation

Yildiz,

Kamanli,

Eskiler

et al. 2024

Lasers Med Sci

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Photodynamic therapy (PDT) is a targeted treatment method that utilizes a photosensitizer (PS) to induce cytotoxicity in malignant and non-malignant tumors. Optimization of PDT requires investigation of the selectivity of PS for the target tissues, irradiating light source, irradiation wavelengths, fluence rate, fluence, illumination mode, and overall treatment plan. In this study, we developed the Multi-mode Automatized Well-plate PDT LED Laboratory Irradiation System (MAWPLIS), an innovative device that automates time-consuming well plate light dosage/PS dose measurement experiment. The careful control of LED current and temperature stabilization in the LED module allowed the system to achieve high optical output stability. The MAWPLIS was designed by integrating a 3-axis moving system and motion controller, a quick-switching LED controller unit equipped with interchangeable LED modules capable of employing multiple wavelengths, and a TEC system. The proposed system achieved high optical output stability (1 mW) within the range of 0-500 mW, high wavelength stability (5 nm) at 635 nm, and high temperature stability (0.2 °C) across all radiation modes. The system’s validation involved in vitro analysis using 5-ALA across varying concentrations, incubation periods, light exposures, and wavelengths in HT-29 colon cancer and WI-38 human lung fibroblast cell lines. Specifically, a combination of 405 nm and 635 nm wavelengths was selected to demonstrate enhanced strategies for colon cancer cell eradication and system validation. The MAWPLIS system represents a significant advancement in photodynamic therapy (PDT) research, offering automation and standardization of time-intensive experiments, high stability and precision, and improved PDT efficacy through dual-wavelength integration.

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Investigation of LED-based photodynamic therapy efficiency on breast cancer cells

et al. 2020

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Comparison of pulse and super pulse radiation modes’ singlet oxygen production effect in antimicrobial photodynamic therapy (AmPDT)

Cited by 4 publications

References 62 publications

Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

Development of a novel laboratory photodynamic therapy device: automated multi-mode LED system for optimum well-plate irradiation

Investigation of LED-based photodynamic therapy efficiency on breast cancer cells

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