Investigation of LED-based photodynamic therapy efficiency on breast cancer cells

Kamanlı, Ali Furkan; Yıldız, Mustafa Zahid; Özyol, Ebru; Özkan, Asuman Deveci; Kucukkara, Elif Sozen; Eskiler, Gamze Güney

doi:10.1007/s10103-020-03061-8

Cited by 6 publications

(1 citation statement)

References 42 publications

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“…For instance, array systems delivering a fluence rate of 100 mW/cm 2 demonstrated a 90% of cell death in ovarian cancer cell line using LED modules reaching a fluence of 50 J/cm 2 [ 62 ]. More recently, LEDs have been used for human breast cancer cell lines showing effective PDT without thermal issues [ 65 ] and for illumination of nanoparticles loaded with the photosensitizer in a human prostate tumour model [ 66 ]. As mentioned previously, thermal control is of paramount importance not only for avoiding possible damage to tissues and organs at risk but also because any temperature variation influences tissue optical properties and biological effects, adding complexity to dosimetry optimisation.…”

Section: Light Technology For Pdtmentioning

confidence: 99%

Light Technology for Efficient and Effective Photodynamic Therapy: A Critical Review

Algorri

Ochoa

Roldán-Varona

et al. 2021

Cancers

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Photodynamic therapy (PDT) is a cancer treatment with strong potential over well-established standard therapies in certain cases. Non-ionising radiation, localisation, possible repeated treatments, and stimulation of immunological response are some of the main beneficial features of PDT. Despite the great potential, its application remains challenging. Limited light penetration depth, non-ideal photosensitisers, complex dosimetry, and complicated implementations in the clinic are some limiting factors hindering the extended use of PDT. To surpass actual technological paradigms, radically new sources, light-based devices, advanced photosensitisers, measurement devices, and innovative application strategies are under extensive investigation. The main aim of this review is to highlight the advantages/pitfalls, technical challenges and opportunities of PDT, with a focus on technologies for light activation of photosensitisers, such as light sources, delivery devices, and systems. In this vein, a broad overview of the current status of superficial, interstitial, and deep PDT modalities—and a critical review of light sources and their effects on the PDT process—are presented. Insight into the technical advancements and remaining challenges of optical sources and light devices is provided from a physical and bioengineering perspective.

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Section: Light Technology For Pdtmentioning

confidence: 99%