Comparison of pulse administration versus once daily administration of itraconazole for the treatment of Malassezia pachydermatis dermatitis and otitis in dogs

Pinchbeck, Lauren R.; Hillier, Andrew; Kowalski, J.; Kwochka, Kenneth W.

doi:10.2460/javma.2002.220.1807

Cited by 36 publications

(46 citation statements)

References 17 publications

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“…7 Both pulse administration and once-daily administration of itraconazole were found to have similar effects in the treatment of canine cutaneous infection caused by M pachydermatis. 12 Our patient achieved good results with combined treatment with oral fluconazole and cryosurgery, indicating that the combination of oral fluconazole and adjunctive cryotherapy is effective in the treatment of skin infection due to M pachydermatis and that the effectiveness of cryotherapy may be related to the vegetative character of the yeast (eg, no growth at 8°C or less). …”

Section: Commentmentioning

confidence: 84%

Granulomatous Skin Infection Caused by Malassezia pachydermatis in a Dog Owner

Fan

Huang²,

Li³

et al. 2006

Arch Dermatol

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Background: Malassezia pachydermatis is part of the normal cutaneous microflora of dogs and many other mammals. M pachydermatis has not yet been reported as an agent that causes skin infection in humans, although it has been found to cause fungemia and other nosocomial infections in preterm newborns and immunocompromised adults.Observations: Malassezia pachydermatis was isolated from the facial granuloma of a healthy woman and her dog's skin scrapings and cerumen. The yeast identity was established by standard methods and scanning electron microscopy. A skin biopsy specimen showed chronic in-flammatory granuloma, numerous purple-red round or ovoid spores in the superficial necrotic tissue, and sparse red spores in the dermis. The skin lesions healed after oral fluconazole and cryotherapy.Conclusions: Definite diagnosis of M pachydermatisinduced skin infection principally depends on the results of fungal culture and histologic examination, and the combination of oral fluconazole and adjunctive cryotherapy seems to be an effective therapeutic regimen.

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Section: Commentmentioning

confidence: 84%

Granulomatous Skin Infection Caused by Malassezia pachydermatis in a Dog Owner

Fan

Huang²,

Li³

et al. 2006

Arch Dermatol

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“…A clinical index score (CIS) was assigned to all dogs at both visits by the primary investigator (MR). The CIS was a modification of a scoring system used in a previous study 12 . The three cytologically evaluated sites were assigned a score from 0 to 3 (0 = absent, 1 = mild, 2 = moderate, and 3 = severe) for each of five features (erythema, hyperpigmentation, greasy exudate, scaling and primary lesions of pustules, papules, and macules).…”

Section: Methodsmentioning

confidence: 99%

Comparison of the clinical efficacy of oral terbinafine and ketoconazole combined with cephalexin in the treatment ofMalasseziadermatitis in dogs – a pilot study

Rosales

Marsella

Kunkle

et al. 2005

Veterinary Dermatology

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The purpose of this randomized, single blinded clinical trial was to evaluate cytologically and clinically the efficacy of oral cephalexin alone and its combination with terbinafine or ketoconazole for the treatment of Malassezia dermatitis in dogs. Twenty-two client-owned dogs with Malassezia dermatitis completed the 3-week study. All received cephalexin (generic, 250 mg or 500 mg) at 22-30 mg kg(-1) twice daily. Eight dogs received terbinafine at 30 mg kg(-1) once daily and seven dogs received ketoconazole (generic, 200 mg) at 5-10 mg kg(-1) twice daily. The remaining seven dogs received cephalexin alone. At week 0 (visit 1) and week 3 (visit 2), mean yeast counts were determined from three affected areas using tape-strip cytology, a clinical index score (CIS) was assigned to the affected areas, and owners evaluated pruritus using a visual analogue scale. All groups showed reduction in mean yeast counts, CIS and pruritus. There was an 86.8%, 80.2% and 28.8% reduction in mean yeast counts from visit 1 to visit 2 for the terbinafine, ketoconazole and cephalexin-only groups, respectively. However, within treatment group comparisons a significant reduction in mean yeast count was only evident for the terbinafine (P < 0.002) and ketoconazole (P < 0.01) groups. Pruritus reduction was only significant for the terbinafine group. These preliminary results suggest that terbinafine should be further assessed for the treatment of canine Malassezia dermatitis.

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“…This 7 day cycle was repeated for two more treatment cycles, totalling 21 days, so that dogs in this group received six doses of terbinafine. Dogs assigned to the daily treatment group received terbinafine hydrochloride orally once daily at a dose of 30 mg/kg for 21 days 20 . The dose of 30 mg/kg of terbinafine orally was derived from empirical dosing of previous studies 14,15 .…”

Section: Methodsmentioning

confidence: 99%

“…Systemic antifungal regimens using pulsatile dosing protocols have been previously investigated and shown to be effective for the treatment of various dermatomycoses in human and veterinary medicine 20–24 . Pulsatile dosing regimens offer several advantages, including less drug exposure during treatment, fewer opportunities for adverse drug events or interactions, improved owner compliance and satisfaction, and decreased expense of therapy 20,25,26 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of once‐daily versus twice‐weekly terbinafine administration for the treatment of canine Malassezia dermatitis – a pilot study

Berger¹,

Lewis²,

Schick³

et al. 2012

Veterinary Dermatology

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Comparison of pulse administration versus once daily administration of itraconazole for the treatment of Malassezia pachydermatis dermatitis and otitis in dogs

Abstract: Results suggested that both pulse administration and once daily administration of itraconazole were efficacious in the treatment of M pachydermatis cutaneous infection in dogs. However, adjunctive treatment may be needed in dogs with M pachydermatis otitis.

Cited by 36 publications

References 17 publications

Granulomatous Skin Infection Caused by Malassezia pachydermatis in a Dog Owner

Granulomatous Skin Infection Caused by Malassezia pachydermatis in a Dog Owner

Comparison of the clinical efficacy of oral terbinafine and ketoconazole combined with cephalexin in the treatment ofMalasseziadermatitis in dogs – a pilot study

Comparison of once‐daily versus twice‐weekly terbinafine administration for the treatment of canine Malassezia dermatitis – a pilot study

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