Comparison of once‐daily versus twice‐weekly terbinafine administration for the treatment of canine <i>Malassezia</i> dermatitis – a pilot study

Berger, Darren J.; Lewis, Thomas P.; Schick, Anthea E.; Stone, Richard

doi:10.1111/j.1365-3164.2012.01074.x

Cited by 26 publications

(32 citation statements)

References 40 publications

(137 reference statements)

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“…The efficacy of terbinafine was subsequently assessed in two clinical trials, either randomized and controlled by a different interval of dosing of terbinafine, or in a small study with concurrent cefalexin therapy (Table ; SoR C‐weak) . Monitoring of serum hepatic enzymes has been recommended for dogs receiving daily oral terbinafine in view of reports of reversible, mild‐moderate elevations of alanine aminotransferase and serum alkaline phosphate . A study designed to integrate pharmacokinetic data with previous MIC data in 10 healthy dogs treated with 30 mg/kg orally once daily for 21 days indicated that terbinafine does not achieve high stratum corneum and sebum concentrations compared with serum values; achieved concentrations barely exceeded previously reported in vitro MIC values .…”

Section: Therapymentioning

confidence: 93%

“…This low‐powered study was not included in the SORT analysis because the outcome is disease‐orientated (yeast count) rather than patient‐oriented (no clinical scoring)(Level of evidence (LoE) 3) . The efficacy of terbinafine was subsequently assessed in two clinical trials, either randomized and controlled by a different interval of dosing of terbinafine, or in a small study with concurrent cefalexin therapy (Table ; SoR C‐weak) . Monitoring of serum hepatic enzymes has been recommended for dogs receiving daily oral terbinafine in view of reports of reversible, mild‐moderate elevations of alanine aminotransferase and serum alkaline phosphate .…”

Section: Therapymentioning

confidence: 99%

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Biology, diagnosis and treatment of Malassezia dermatitis in dogs and cats Clinical Consensus Guidelines of the World Association for Veterinary Dermatology

Bond

Morris

Guillot

et al. 2020

Veterinary Dermatology

118

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Background -The genus Malassezia is comprised of a group of lipophilic yeasts that have evolved as skin commensals and opportunistic cutaneous pathogens of a variety of mammals and birds.Objectives -The objective of this document is to provide the veterinary community and other interested parties with current information on the ecology, pathophysiology, diagnosis, treatment and prevention of skin diseases associated with Malassezia yeasts in dogs and cats.Methods and material -The authors served as a Guideline Panel (GP) and reviewed the literature available prior to October 2018. The GP prepared a detailed literature review and made recommendations on selected topics. The World Association of Veterinary Dermatology (WAVD) Clinical Consensus Guideline committee provided guidance and oversight for this process. The document was presented at two international meetings of veterinary dermatology societies and one international mycology workshop; it was made available for comment on the WAVD website for a period of six months. Comments were shared with the GP electronically and responses incorporated into the final document.Conclusions and clinical importance -There has been a remarkable expansion of knowledge on Malassezia yeasts and their role in animal disease, particularly since the early 1990's. Malassezia dermatitis in dogs and cats has evolved from a disease of obscurity and controversy on its existence, to now being a routine diagnosis in general veterinary practice. Clinical signs are well recognised and diagnostic approaches are well developed. A range of topical and systemic therapies is known to be effective, especially when predisposing factors are identified and corrected.

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Section: Therapymentioning

confidence: 93%

Section: Therapymentioning

confidence: 99%

Biology, diagnosis and treatment of Malassezia dermatitis in dogs and cats Clinical Consensus Guidelines of the World Association for Veterinary Dermatology

Bond

Morris

Guillot

et al. 2020

Veterinary Dermatology

118

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“…Published reports of its use either as treatment for dermatophytosis or pharmacokinetic studies were reviewed for mention of adverse effects . Because of the low number of dogs treated with terbinafine described in the literature, two studies involving the use of terbinafine for the treatment of Malassezia were included . Studies reported that the drug was well tolerated, adverse effects were uncommon and mild, and no study reported any deaths associated with the administration of the drug.…”

Section: Systemic Treatmentmentioning

confidence: 99%

“…One study reported that treatment was stopped for one of 12 cats due to three episodes of vomiting . Intermittent soft stools and diarrhoea were reported in dogs and cats; however, in one placebo‐controlled study this occurred with equal frequency in dogs receiving the placebo . When haematological parameters were monitored in dogs or cats, mild elevations in serum ALT or SAP were noted.…”

Section: Systemic Treatmentmentioning

confidence: 99%

Diagnosis and treatment of dermatophytosis in dogs and cats.

Moriello

Coyner²,

Paterson

et al. 2017

Veterinary Dermatology

200

147

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Background -Dermatophytosis is a superficial fungal skin disease of cats and dogs. The most common pathogens of small animals belong to the genera Microsporum and Trichophyton. It is an important skin disease because it is contagious, infectious and can be transmitted to people.Objectives -The objective of this document is to review the existing literature and provide consensus recommendations for veterinary clinicians and lay people on the diagnosis and treatment of dermatophytosis in cats and dogs. Conclusions -No one diagnostic test was identified as the gold standard. Successful treatment requires concurrent use of systemic oral antifungals and topical disinfection of the hair coat. Wood's lamp and direct examinations have good positive and negative predictability, systemic antifungal drugs have a wide margin of safety and physical cleaning is most important for decontamination of the exposed environments. Finally, serious complications of animal-human transmission are exceedingly rare. Methods - Clinical Consensus GuidelinesClinical Consensus Guidelines (CCGs) provide the veterinary community with current information on the pathophysiology, diagnosis and treatment of commonly encountered dermatological conditions. The World Association for Veterinary Dermatology (WAVD) oversees selection of relevant topics, identification of panel members possessing the expertise to draft the Clinical Consensus Guidelines, and any other aspects required to assure the integrity of the process. The statements are derived from evidence-based medicine whenever possible, however when such evidence does not exist then expert opinions would be utilized by the members of the panel. A draft is prepared by the panel, followed by a presentation of the guidelines at major national and/or international veterinary meetings. Access to the guidelines will be available on the WAVD web site. Solicitation for input from WAVD member organizations and affiliate and provisional member groups will result in the incorporation of this feedback into the guidelines. The final CCG manuscript will be submitted to the Veterinary Dermatology journal, where it is reviewed and edited before publication. The authors are solely responsible for the content of the statements.

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“…13 14 Terbinafine has also been used systemically in the treatment of dermatophytosis in dogs and cats, 15 16 as well as in the treatment of canine Malassezia dermatitis. [17][18][19] In addition, topical terbinafine has been used successfully to treat dermatophytosis in mice, 20 and in a guinea pig model. 21 Of note, Sagit and others, 22 report no toxicity to the middle ear of rats when terbinafine was applied intratympanically.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a single‐administration ototopical treatment for canine otitis externa: a randomised trial

Blake

Keil

Kwochka

et al. 2017

Veterinary Record Open

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ObjectiveTo evaluate the efficacy and safety of a new, single-administration Otic Solution containing florfenicol, terbinafine and mometasone furoate for the treatment of canine otitis externa (OE).DesignThe clinical efficacy and safety study was a multicentre, controlled, masked and randomised field study conducted over 30 days. Two hundred and twenty-one (221) client-owned dogs of varying breeds with diagnosed bacterial and/or fungal OE were enrolled.ProcedureDogs were randomised to either Otic Solution or control groups. Evaluations were conducted over a minimum period of 30 days with a primary effectiveness endpoint based on the improvement in a clinical severity score at the final visit (day 30). Safety analyses were based on clinical and laboratory parameters and the occurrence of adverse events.ResultsThe Otic Solution group demonstrated a significantly higher treatment success rate compared with that observed for the control group (72.5 per cent v 11.1 per cent, P value=0.0001) for cases of OE caused by Staphylococcus pseudintermedius and Malassezia pachydermatis. No significant safety findings were reported.Conclusions/clinical relevanceThis new ototopical formulation provides safe and effective treatment of canine OE and is an important alternative antimicrobial for this indication. The single-administration dosage regimen eliminates opportunities for client dosage administration errors and medication stockpiling.

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Comparison of once‐daily versus twice‐weekly terbinafine administration for the treatment of canine Malassezia dermatitis – a pilot study

Abstract: This pilot study indicates that twice-weekly terbinafine administration may be an effective alternative treatment for canine Malassezia dermatitis and merits further investigation.

Cited by 26 publications

References 40 publications

Biology, diagnosis and treatment of Malassezia dermatitis in dogs and cats Clinical Consensus Guidelines of the World Association for Veterinary Dermatology

Biology, diagnosis and treatment of Malassezia dermatitis in dogs and cats Clinical Consensus Guidelines of the World Association for Veterinary Dermatology

Diagnosis and treatment of dermatophytosis in dogs and cats.

Evaluation of a single‐administration ototopical treatment for canine otitis externa: a randomised trial

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