Comparison of protein–polysaccharide nanoparticle fabrication methods: Impact of biopolymer complexation before or after particle formation

Jones, Owen G.; Decker, Eric A.; McClements, David Julian

doi:10.1016/j.jcis.2009.12.017

Cited by 102 publications

(47 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We envisage that the WPP01 particle has a composite mixed structure of aggregated WPC intermixed with degraded pectin. Matalanis et al [29] have described such a structure as a "heterogeneous continuous" biopolymer complex and are similar to the "type 2" particles described in the work of Jones et al [12] For WPP02 and WPP03, the protein is heated first and then mixed with pectin after heating. The pectin will form a layer on the surface of the protein particles through electrostatic interaction to form heterogeneous core-shell particles with a core of denatured WPC and an outer shell of pectin.…”

Section: Particle Sizementioning

confidence: 85%

“…[3,9,14] Samples were left standing at room temperature for 20 min with continuous stirring at the desired pH before further use. [3,11,12] To form molecular complexes or protein-polysaccharide particles, protein and pectin solutions were mixed in the appropriate mass ratio and then heated together or heated individually before mixing with the other (see Table 1). After the samples had been heated in the water bath, they were removed and placed immediately into an ice bath for 3 h to ensure rapid cooling and to bring all aggregation reactions to a halt.…”

Section: Biopolymer Suspension Preparation and Fabrication Techniquesmentioning

confidence: 99%

See 1 more Smart Citation

Electrostatic complexes of whey protein and pectin as foaming and emulsifying agents

Oduse¹,

Campbell

Lonchamp

et al. 2017

International Journal of Food Properties

View full text Add to dashboard Cite

Five types of electrostatic complex (macromolecular complexes, core-shell particles, and mixed homogeneous particles) were formed between whey protein (whey protein concentrate [WPC]) and pectin. By controlling the thermal treatment, composition, and order of mixing, it was possible to produce complexes that for the same biopolymer concentration gave differing functional properties. All protein-pectin complexes showed higher foaming ability and stability than native or heated WPC without pectin. Native WPC had higher emulsifying ability than protein-pectin complexes but exhibited the lowest emulsion stability. Ingredients based on such ideas might offer the food manufacturer greater control over food structure, stability, and organoleptic properties. ARTICLE HISTORY

show abstract

Section: Particle Sizementioning

confidence: 85%

Section: Biopolymer Suspension Preparation and Fabrication Techniquesmentioning

confidence: 99%

Electrostatic complexes of whey protein and pectin as foaming and emulsifying agents

Oduse¹,

Campbell

Lonchamp

et al. 2017

International Journal of Food Properties

View full text Add to dashboard Cite

show abstract

“…In this section, we review a number of approaches to fabricate this type of particle. Biopolymer particles can be formed when globular protein solutions are heated above their thermal denaturation temperature (T m ) under conditions where there is a relatively weak attraction between the protein molecules (Jones, Decker, & McClements, 2010;Jones & McClements, 2010b). The size and charge of these biopolymer particles can be controlled by altering the initial biopolymer concentration, holding temperature, holding time, pH and ionic strength.…”

Section: Biopolymer Particles: Single Biopolymer Typementioning

confidence: 99%

“…4). Recently it has been shown that biopolymer particles can be formed by heating mixtures of proteins and polysaccharides together under conditions where they form molecular complexes (Jones, Decker, & McClements, 2009;Jones, Decker, et al, 2010;Jones, Lesmes, Dubin, & McClements, 2010;Jones & McClements, 2008, 2010a.…”

Section: Biopolymer Particles: Mixed Biopolymer Typementioning

confidence: 99%

Structured biopolymer-based delivery systems for encapsulation, protection, and release of lipophilic compounds

2011

Self Cite

View full text Add to dashboard Cite

Available at: https://works.bepress.com/djulian_mcclements/160/ This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues. such as u-3 rich oils, conjugated linoleic acid (CLA), oil-soluble vitamins, flavors, colors, and nutraceuticals. This article provides an overview of a number of different approaches that can be used to create structured delivery systems based on biopolymers, including molecular complexation, coacervation, thermodynamic incompatibility, moulding, and extrusion methods. These delivery systems can be produced from food-grade ingredients using simple processing operations (e.g., mixing, homogenizing, and thermal processing). The structure, production, performance, and potential applications of each type of structured delivery system are discussed.

show abstract

“…Uma vez sendo conhecida a estrutura primária da proteína, os sistemas podem veicular princípios ativos covalentemente ligados à proteína e serem modificadas as suas propriedades de superfície [23] . A albumina é uma proteína de origem animal, obtida a partir do soro humano ou bovino.…”

Section: Peptideos E Proteínasunclassified

Polímeros usados como sistemas de transporte de princípios ativos

Severino¹,

Santana

Malmonge

et al. 2011

Polímeros

View full text Add to dashboard Cite

Resumo: Os diferentes sistemas de transporte têm evidenciado potencial terapêutico para uma grande variedade de princípios ativos, satisfazendo vários requisitos, como a prevenção da sua eliminação rápida do organismo, a redução da sua toxicidade sistêmica, a estabilização e a otimização do seu metabolismo, e o direcionamento específico ao local alvo e os mecanismos de defesa. No entanto, têm sido reconhecidos vários outros desafios associados à liberação específica do princípio ativo ao local alvo, pelo que, para ultrapassar os obstáculos químicos e biológicos, a seleção do polímero utilizado para a preparação do sistema de transporte é de importância crucial. O presente trabalho apresenta um relato sobre os principais polímeros naturais e sintéticos utilizados para a preparação de sistemas de transporte de princípios ativos in vivo. Palavras-chaves: Polímeros sintéticos, polímeros naturais, transporte de princípios ativos. Polymers for Drug Delivery Systems FormulationsAbstract: The different carrier systems have shown therapeutic potential for a wide variety of drugs, satisfying multiple requirements, such as prevention of rapid elimination, reducing toxicity, promoting stabilization, optimization of metabolism, drug delivery and defense mechanisms. However, it has been recognized several other challenges associated with the specific release of actives in drug delivery. Therefore, to overcome chemical and biological obstacles, the selection of the polymer used to prepare the transport system is crucial. This paper presents a report on the main natural and synthetic polymers used in the preparation of drug carrier systems in vivo. Keywords: Synthetic polymers, natural polymers, carrier of drugs. IntroduçãoA investigação científica de novos meios de veiculação de princípios ativos in vivo permitiu o desenvolvimento de vários tipos de sistemas de transporte dos quais se destacam os lipossomas [1] , conjugados de polímero e princípios ativos [2] , micelas de copolímeros anfipáticos [3] , micro e nanopartículas poliméricas [4] e, mais recentemente, as nanopartículas lipídicas sólidas [5] . Os diferentes sistemas de transporte têm evidenciado potencial terapêutico para uma grande variedade de princípios ativos, preenchendo assim vários requisitos, como a prevenção da sua eliminação rápida do organismo [6] , a redução da sua toxicidade sistêmica [7] , a estabilização e a otimização do seu metabolismo [8] , o direcionamento específico ao local alvo [9] e os mecanismos de defesa [10] . No entanto, têm sido reconhecidos vários outros desafios associados à liberação específica do princípio ativo ao local alvo, pelo que, para ultrapassar os obstáculos químicos e biológicos, a seleção do polímero utilizado para a preparação do sistema de transporte é de importância crucial.Para a preparação dos sistemas poliméricos de transporte, pode recorrer-se ao uso de polímeros naturais [11] , sintéticos [12] ou semi-sintéticos [13] . A seleção do polímero a ser empregado está condicionada, em grande medida pela natureza do princípio...

show abstract

Comparison of protein–polysaccharide nanoparticle fabrication methods: Impact of biopolymer complexation before or after particle formation

Cited by 102 publications

References 34 publications

Electrostatic complexes of whey protein and pectin as foaming and emulsifying agents

Electrostatic complexes of whey protein and pectin as foaming and emulsifying agents

Structured biopolymer-based delivery systems for encapsulation, protection, and release of lipophilic compounds

Polímeros usados como sistemas de transporte de princípios ativos

Contact Info

Product

Resources

About