Structured biopolymer-based delivery systems for encapsulation, protection, and release of lipophilic compounds

Abstract

Available at: https://works.bepress.com/djulian_mcclements/160/ This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues. such as u-3 rich oils, conjugated linoleic acid (CLA), oil-soluble vitamins, flavors, colors, and nutraceuticals. This article provides an overview of a number of different approaches that can be used to create structured delivery systems based on biopolymers, including molecular complexation, coacervation, thermodynamic incompatibility, moulding, and extrusion methods. These delivery systems can be produced from food-grade ingredients using simple processing operations (e.g., mixing, homogenizing, and thermal processing). The structure, production, performance, and potential applications of each type of structured delivery system are discussed.

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

“…As they are biocompatible and biodegradable, the body through usual metabolic processes can excrete them. In addition, they are extremely versatile and can be processed in the most varied forms, such as films, beads, and foams [16,17].…”

PRISM-Based Theory of Complex Coacervation: Excluded Volume versus Chain Correlation

“…[1][2][3][4][5][6] Historical and current investigations into complex coacervates have studied the formation of such phases in natural polymers, such as proteins or polysaccharides, which are currently widely used as food additives. [7][8][9][10][11][12][13][14][15][16][17][18] Despite the utility of these systems, there has only recently been a resurgence of interest in their molecular behavior, in particular for its promise as a powerful route to self-assembled materials such as micelles, 3,[19][20][21][22] block copolymers, [23][24][25][26] and layer-bylayer assembly. [27][28][29][30] This recent activity in the field is concomitant with a desire to emulate the molecular features observed in a number of biological materials, such as underwater adhesives in mussels and the matrix adhesive holding together the dwelling of a sandcastle worm.…”

Multilayer Oil-in-Water Emulsions: Formation, Characteristics and Application as the Carriers for Lipophilic Bioactive Food Components – a Review

“…However, the electrical charge distribution on protein surfaces is heterogeneous with varying amounts of positive and negative regions and even though the net charge on protein is zero at its pI, the protein still has both positive and negative regions on its surface and thus it can be involved in attractive and/or repulsive electrostatic Polysaccharides are polymers of monosaccharides differing from one another chemically in terms of the type, number, sequence and bonding of the monosaccharides within the polymer chain. These chemical differences lead to variations in molecular properties, such as molecular weight, degree of branching, structure, flexibility, electrical charge, and interactions [Stauffer, 2001;Matalanis et al, 2011]. Molecular conformations of polysaccharides are limited to random coil or helical structures.…”

“…pectin, alginate, xanthan, carboxymethylcellulose) and (iii) amino groups (e.g. chitosan): -SO 4 H ↔ -SO 4 -(pK a ~ 2); -CO 2 H ↔ -CO 2 -(pK a ~ 3.5); -NH 3 + ↔ -NH 2 (pK a ~ 6.5) [Aoki et al, 2005;Matalanis et al, 2011]. In an acid environment chitosan behaves as polycationic electrolyte and this yields antifungal or antimicrobial activities since cations can bind to anionic sites on bacterial and fungal cell wall surfaces [de Vos et al, 2010;Weiss et al, 2006].…”