Comparison of propofol and methohexitone as anaesthetic agents for electroconvulsive therapy

Dwyer, R.; McCaughey, W.; Lavery, J. Patrick; McCarthy, Grace C.; Dundee, J. W.

doi:10.1111/j.1365-2044.1988.tb06631.x

Cited by 63 publications

(22 citation statements)

References 9 publications

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“…Our mean seizure duration was 22.56 seconds with propofol compared to 37.5 seconds reported by W. Boey and F.O. Lai (8) , 23.9 seconds reported by Dwyer et al (13) and 18.0 seconds by Rouse and colleagues (12) . Simpson et al (26) reported seizure duration as a median of 19.0 seconds.…”

Section: Seizure Durationmentioning

confidence: 41%

“…This larger dose of propofol produced no greater reduction of the rise in systolic blood pressure than our study (reaching 3mmHg below the baseline value). Dwyer et al (13) administered propofol 1.51 mg/kg and, in a single post seizure measurement, found that systolic pressure rose by 20mmHg or more only in 10% of patients, compared to in 30% of patients who received 1.19mg/kg methohexital.…”

Section: Haemodynamic Variabilitymentioning

confidence: 99%

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Comparison of the haemodynamic effects and seizure activity during modified ECT with thiopentone and propofol used as inducing agents.

Premendran¹

2012

iosrphr

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Abstract:--Electroconvulsive therapy is also known as Electroshock or Shock therapy or Electroplex.Seizure activity produced by ECT is considered as the therapeutic aspect of this form of treatment, but is accompanied by untoward physiologic consequences, mainly cardiovascular and cerebral in nature. The hemodynamic effects can have a significant impact in patients with underlying cardiovascular disease.The effects of certain anesthetic agents may render seizure activity difficult to generate,and the unmodified physiologic consequences of treatment may be harmful. At the present time, a number of medications have been used during ECT including pretreatment sedation, anaesthetic agents, muscle relaxants, anticholinergics, and drugs to attenuate parasympathetic and sympathetic responses. This single blinded study was carried out on 100 adult patients equally divided into two groups of 50 each to compare the Hemodynamic effects and seizure activity of thiopentone sodium (GroupT) and propofol(Group P) when used as inducing agents in patients undergoing modified electroconvulsive therapy (MECT). Results showed propofol maintained significantly better haemodynamics compared to thiopentone and seizure time was significantly lower with propofol compared to thiopentone with equal theurapeutic effect and comparable complication rate of MECT. Recovery from anaesthesia post MECT was significantly quicker with propofol compared with thiopentone. Hence,we conclude that from anaesthesiologist's point of view propofol has advantage over thiopentone when used as an induction agent for modified ECT due to its favorable haemodynamics and early recovery characteristics.

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Section: Seizure Durationmentioning

confidence: 41%

Section: Haemodynamic Variabilitymentioning

confidence: 99%

Comparison of the haemodynamic effects and seizure activity during modified ECT with thiopentone and propofol used as inducing agents.

Premendran¹

2012

iosrphr

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“…4 For therapeutic response to occur, the seizure should be at least 20-30 seconds duration for a minimum aggregate of 210seconds. However, the relationship between the therapeutic efficacy of MECT and cerebral seizure activity remains controversial.…”

Section: Parametermentioning

confidence: 99%

Comparison of Propofol and Thiopentone as Induction Agents for Modified Electroconvulsive Therapy

Mukundan¹,

Mahmood²,

Padmanabha³

2015

jemds

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ABSTRACT:The aim of the study was to compare the seizure duration, haemodynamic changes and recovery characteristics following modified electro convulsive therapy (ECT) between propofol and thiopentone, used as anaesthetic agents. Forty patients who presented for a minimum of two ECT treatments consecutively were studied. Patients were randomly allocated to receive either 1 % propofol or 2.5 % thiopentone for their first treatment and the other drug was administered on the second occasion. All patients were preoxygenated for three minutes. Isolation of a limb was done in the upper limb at the level of the arm by using a blood pressure cuff that was inflated 50mmHg above systolic blood pressure. Anaesthesia was induced. Following the onset of anaesthetic effect, depolarizing muscle relaxant succinyl choline was administered intravenously. Muscle fasiculations or fine twitching movements monitored. The electrical stimulus was delivered by the attending psychiatrist using bifrontal electrodes. The duration of motor seizure in isolated limb was recorded. Thus concluding propofol is better induction agent than thiopentone sodium for modified electroconvulsive therapy.

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“…A rcccnt study of electrical seizure duration, measured by simplified EEG, has shown that propofol significantly reduced mean electrical seizure time to 43.2 seconds compared with 57.3 seconds after methohexitone. 2 We wondered whether the isolated arm technique, as recommended by Fink and J o h n~o n ,~ was used by Rouse to measure seizure quality and duration; this technique correlates highly with EEG measurement of seizure duration, and prevents partial paralysis with suxamethonium Prom influencing the results. We do not consider that the quality of the seizure can be commented upon if the isolated arm is not used to exclude thc effects of the relaxant.…”

Section: Program For Bbc B Microcomputer To Record Data From Anaesthementioning

confidence: 99%

The use of propofol for anaesthesia for electroconvulsive therapy

Simpson

Halsall

1988

Anaesthesia

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Comparison of propofol and methohexitone as anaesthetic agents for electroconvulsive therapy

Abstract: SummaryPropojol was compared to

Cited by 63 publications

References 9 publications

Comparison of the haemodynamic effects and seizure activity during modified ECT with thiopentone and propofol used as inducing agents.

Comparison of the haemodynamic effects and seizure activity during modified ECT with thiopentone and propofol used as inducing agents.

Comparison of Propofol and Thiopentone as Induction Agents for Modified Electroconvulsive Therapy

The use of propofol for anaesthesia for electroconvulsive therapy

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