Comparison of the haemodynamic effects and seizure activity during modified ECT with thiopentone and propofol used as inducing agents.

Abstract

Abstract:--Electroconvulsive therapy is also known as Electroshock or Shock therapy or Electroplex.Seizure activity produced by ECT is considered as the therapeutic aspect of this form of treatment, but is accompanied by untoward physiologic consequences, mainly cardiovascular and cerebral in nature. The hemodynamic effects can have a significant impact in patients with underlying cardiovascular disease.The effects of certain anesthetic agents may render seizure activity difficult to generate,and the unmodified physiologic consequences of treatment may be harmful. At the present time, a number of medications have been used during ECT including pretreatment sedation, anaesthetic agents, muscle relaxants, anticholinergics, and drugs to attenuate parasympathetic and sympathetic responses. This single blinded study was carried out on 100 adult patients equally divided into two groups of 50 each to compare the Hemodynamic effects and seizure activity of thiopentone sodium (GroupT) and propofol(Group P) when used as inducing agents in patients undergoing modified electroconvulsive therapy (MECT). Results showed propofol maintained significantly better haemodynamics compared to thiopentone and seizure time was significantly lower with propofol compared to thiopentone with equal theurapeutic effect and comparable complication rate of MECT. Recovery from anaesthesia post MECT was significantly quicker with propofol compared with thiopentone. Hence,we conclude that from anaesthesiologist's point of view propofol has advantage over thiopentone when used as an induction agent for modified ECT due to its favorable haemodynamics and early recovery characteristics.

Prospective, randomised, controlled comparison study between ultrasound guided technique with conventional landmark technique of internal jugular vein cannulation

“…mean age, gender distribution, mean weight, ASA grade was statiscally significant. Studies conducted by Omprakash TM et al [10] , Kumar A et al [11] , Premendran B et al [12] , Mir AH et al [13] showed similar results as our study. Increase in the heart rate, SBP, DBP & MAP after ECT was observed in all 3 groups.…”

“…Mean duration of Anaesthesia was least in Propofol, had significantly earliest & smooth recovery (p<0.01) followed by Etomidate and Thiopentone. Rosa MA et al [18] , Premendran B et al [12] showed results concurrent with our study.…”

Etomidate and Ketofol as induction agents: A comparative study of haemodynamic parameters

“…In ECT, the main objective of general anaesthesia is to produce an unconscious state with muscle paralysis [4] . Recovery pattern, hemodynamic effects, activity of seizure, cognitive functions and cost effectiveness of the procedure is the choice of anaesthetic agent [5] . The present study evaluates and compares the effects of propofol and etomidate on recovery pattern, hemodynamic effects and activity of seizures in patients undergoing electroconvulsive therapy (ECT).…”