Comparison of Postprandial Profiles of Ghrelin, Active GLP-1, and Total PYY to Meals Varying in Fat and Carbohydrate and Their Association With Hunger and the Phases of Satiety

Gibbons, Catherine; Caudwell, Phillipa; Finlayson, Graham; Webb, Dominic-Luc; Hellström, Per M.; Näslund, Erik; Blundell, John

doi:10.1210/jc.2012-3835

Cited by 141 publications

(143 citation statements)

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“…Water was available to participants ad libitum on the first test day, and this was matched on their second test day. Blood sampling and Visual Analogue Scale (VAS) appetite sensation measures were taken at specific time points until an ad libitum lunch meal was provided (see Figure 1 reproduced from [14]). Time points of 0 (fasting), 10, 20 30, 60, 90, 120 and 180 minutes post-breakfast were used.…”

Section: Methodsmentioning

confidence: 99%

“…It is important to note that this study has been published previously [14], which can be referred to for further details. At the time of this publication, we did not have the CCK data, nor did we know it was possible.…”

Section: Participantsmentioning

confidence: 99%

“…At the time of this publication, we did not have the CCK data, nor did we know it was possible. Therefore, some of the data from the participants in this study were included in a previous publication, particularly the insulin/glucose and subjective appetite data [14]. However, all of the CCK peptide data reported here are novel and have not been used in any other publication.…”

Section: Participantsmentioning

confidence: 99%

“…As presented in [14], the breakfast meal consisted of yoghurt, honey and fruit with a choice of tea/coffee. The two conditions were matched for weight (685 g) and provided 2466 kJ.…”

Section: Test Mealsmentioning

confidence: 99%

“…There was no significant effect of gender on fasting metabolic or appetite hormone levels therefore men and women were analysed together. Due to the individual variability in blood parameters and peptide levels the change from fasting at each time point was calculated for each individual as conducted previously [14].…”

Section: Statisticsmentioning

confidence: 99%

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Postprandial profiles of CCK after high fat and high carbohydrate meals and the relationship to satiety in humans

et al. 2016

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, D-L., Hellström, P M. et al. (2015) Postprandial profiles of CCK after high fat and high carbohydrate meals and the relationship to satiety in humans. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Participants and Design:Sixteen overweight/obese adults (11female/5male) participated in a randomised-crossover study (46years,29.8kg/m 2 ) in a university research centre. Plasma was collected preprandially and for 180min postprandially. Simultaneously, ratings of hunger/fullness were tracked for 180min before an ad libitum lunch was provided.Results: CCK8/33(s) levels increased more rapidly and reached a higher peak following HF =0.201,p=0.844). CCK8/33(s) profiles were not associated with subjective appetite during early and late phases of satiety; nor was there an association between CCK8/33(s) and meal size.Conclusions: These results demonstrate CCK levels were higher after HF meal compared to HCHO isocaloric meal. There was no association between CCK levels and intensity of satiety, or with meal size. Under these circumstances, CCK does not appear to play a unique independent role in satiety/satiation. CCK probably acts in conjunction with other peptides and the action of the stomach.

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Section: Methodsmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

“…As presented in [14], the breakfast meal consisted of yoghurt, honey and fruit with a choice of tea/coffee. The two conditions were matched for weight (685 g) and provided 2466 kJ.…”

Section: Test Mealsmentioning

confidence: 99%

Section: Statisticsmentioning

confidence: 99%

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