Comparison of photoinactivation of T. rubrum by new methylene blue (NMB) and indocyanine green (EmunDo ® )

Fekrazad, Reza; Mir, Arash Poorsattar Bejeh; Aghdam, Mina Kahyaie; Barghi, Vadood Ghasemi

doi:10.1016/j.pdpdt.2016.10.013

Cited by 7 publications

(12 citation statements)

References 29 publications

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“…Nevertheless, the reduction was found out at the level of ca. 1 log [74,79,85,248], simultaneously Afroozi et al indicated remarkable adjuvant impact of ICG on the conventional treatment of denture stomatitis caused by C. albicans infection with nystatin [249]. It should be mentioned that Azizi et al reported the same growth inhibition of C. albicans by PACT mediated 58 and conventional antiseptic agents like chlorhexidine and the antifungal drug nystatin [79].…”

Section: Other Photosensitizersmentioning

confidence: 97%

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Photosensitizers Mediated Photodynamic Inactivation against Fungi

Ziental

Mlynarczyk

Czarczyńska-Goślińska

et al. 2021

Nanomaterials

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Superficial and systemic fungal infections are essential problems for the modern health care system. One of the challenges is the growing resistance of fungi to classic antifungals and the constantly increasing cost of therapy. These factors force the scientific world to intensify the search for alternative and more effective methods of treatment. This paper presents an overview of new fungal inactivation methods using Photodynamic Antimicrobial Chemotherapy (PACT). The results of research on compounds from the groups of phenothiazines, xanthanes, porphyrins, chlorins, porphyrazines, and phthalocyanines are presented. An intensive search for a photosensitizer with excellent properties is currently underway. The formulation based on the existing ones is also developed by combining them with nanoparticles and common antifungal therapy. Numerous studies indicate that fungi do not form any specific defense mechanism against PACT, which deems it a promising therapeutic alternative.

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Section: Other Photosensitizersmentioning

confidence: 97%

“…On the other hand, 58 excited with lower wavelengths works as a typical PS in PDT. Fekrazad et al reported activity of 58 in decreasing growth rate of C. albicans and T. rubrum [74,85,248]. Nevertheless, the reduction was found out at the level of ca.…”

Section: Other Photosensitizersmentioning

confidence: 98%

Photosensitizers Mediated Photodynamic Inactivation against Fungi

Ziental

Mlynarczyk

Czarczyńska-Goślińska

et al. 2021

Nanomaterials

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“…Moreover, they can easily transmit from one person to the another. 4 In clinics, localised or oral administrations of anti-fungal drugs are the current treatments of superficial mycoses. 5 However, these drugs are still limited by their side effects such as narrow spectrum, long treatment duration, high hepatotoxicity to host and medical cost.…”

Section: Introductionmentioning

confidence: 99%

“…Although T rubrum ‐caused infections are not life threatening, they are chronic, recurrent and poorly respond to available treatments. Moreover, they can easily transmit from one person to the another 4 . In clinics, localised or oral administrations of anti‐fungal drugs are the current treatments of superficial mycoses 5 .…”

Section: Introductionmentioning

confidence: 99%

“…PS plays a key role among the three elementary components in aPDT. Previous in vitro studies demonstrated that T rubrum could be effectively killed by a wide variety of PSs including rose bengal (RB), 11 5‐aminolevulinic acid (5‐ALA), 12 curcumin, 13 indocyanine green (ICG), 14 methylene blue (MB), 15 toluidine blue (TBO), 16 hypericin 17 and phthalocyanine 4 (Pc 4) 18 . Several clinical case reports also revealed that 5‐ALA–mediated aPDT could completely cure the onychomycosis and tinea cruris in patients caused by T rubrum 19‐21 …”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the photodynamic efficacy and effects of haematoporphyrin monomethyl ether on Trichophyton rubrum microconidia in vitro

Pan

Liu

et al. 2020

Mycoses

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Background: Current available treatment modes against dermatophytoses are often tedious and sometimes unsatisfactory. As an emerging and promising approach, antimicrobial photodynamic therapy (aPDT) attracts much attention in the treatment of superficial or localised infections. Objectives: This work investigated the photodynamic efficacy and effects of haematoporphyrin monomethyl ether (HMME) on microconidia of Trichophyton rubrum in vitro. Methods: The photodynamic killing efficacy of HMME on microconidia of two T rubrum strains was assessed by MTT assay. The effects of HMME-mediated aPDT on the growth of T rubrum and cellular structure of microconidia were also investigated. Confocal laser scanning microscopy (CLSM) and flow cytometry were employed to study the intracellular localisation of HMME and generation of reactive oxygen species (ROS). Results: HMME showed no obvious toxicity in the dark, but after light irradiation it inactivated the T rubrum microconidia in a light energy dose-dependent manner, and inhibited the growth of T rubrum. CLSM demonstrated that HMME initially bound to the cell envelop and entered into the cell after light irradiation. HMME-mediated aPDT also damaged the cell cytoplasm and increased the accumulation of intracellular ROS, resulting in cell death. Conclusions: The results suggested that HMME-mediated aPDT had potential to be used in the treatment of superficial infections caused by T rubrum.

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