Comparison of PET/CT with conventional imaging modalities (USG, CECT) in evaluation of N0 neck in head and neck squamous cell carcinoma

Chauhan, Ashutosh; Kulshrestha, Pranjal; Kapoor, Sanjay; Singh, Hariqbal; Jacob, MJ; Patel, Maneel; Ganguly, Manomoy

doi:10.1016/j.mjafi.2012.02.012

Cited by 14 publications

(12 citation statements)

References 26 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The NPV of PET/CT using visual interpretation (NPV, approximately 0.87) specific to the clinical-N0 side and SUV analysis (NPV, approximately 0.94) specific to the nodal basins was high. Previous studies have shown a high NPV for FDG-PET/CT for the N0 neck in single-institution series, [23][24][25] with some other single-institution data showing lower NPVs (NPV, approximately 65%). 26 To our knowledge, this is the first prospective, multicenter study to show that the NPV of FDG-PET/CT is 87% or greater.…”

Section: Discussionmentioning

confidence: 81%

“…44 Single-institution studies and modeling paradigms suggest that PET/CT may be better able to characterize the N0 neck, although there is disagreement in the literature. 18,23,[45][46][47][48][49][50][51] None of the studies have sufficient sample size to provide adequate CIs for their results, and many included varied patient groups, with both untreated and recurrent disease, as well as various tumor histologies. This study attempted to respond to these weaknesses in the published literature, and our results show that the NPV of PET/CT was high ($ 87%) for the clinical N0 neck in a multicenter, homogeneous population of participants with HNSCC.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Multicenter Trial of [¹⁸F]fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Staging of Head and Neck Cancer and Negative Predictive Value and Surgical Impact in the N0 Neck: Results From ACRIN 6685

Lowe

Duan

Subramaniam

et al. 2019

JCO

View full text Add to dashboard Cite

PURPOSE The objective of this study was to determine the negative predictive value (NPV) of positron emission tomography (PET)/computed tomography (CT) for the clinically N0 neck on the basis of neck dissection. METHODS Participants with newly diagnosed, first-time, head and neck squamous cell carcinoma (HNSCC) and at least one clinically N0 neck side for which dissection was planned were included. A total of 287 participants were prospectively enrolled from 23 American College of Radiology Imaging Network-qualified institutions. PET/CT was compared with findings at neck dissection. RESULTS PET/CT scans and pathology findings were available for 270 N0 neck sides from 212 participants. For visual assessment, the NPV specific to the clinical-N0 sides was 0.868 (95% CI, 0.803 to 0.925). For dichotomized maximum standardized uptake value, the NPVs specific to the nodal basins were 0.940 (95% CI, 0.928 to 0.952) and 0.937 (95% CI, 0.925 to 0.949) at prespecified cutoffs of 2.5 and 3.5, respectively. The optimal cutoff maximum standardized uptake value was determined to be 1.8, with an NPV of 0.942 (95% CI, 0.930 to 0.953). The PET/CT-informed surgical treatment plan was changed in 51 of 237 participants (22%) compared with the PET/CT-blinded surgical plan. In 34 participants (14%), this led to planned dissection of additional nodal levels. In 12 participants (5%), this led to fewer planned dissected nodal levels. Negative PET/CT scans in N0 necks was true negative in 87% and false negative in 13%. CONCLUSION [18F]fluorodeoxyglucose-PET/CT has high NPV for the N0 neck in T2 to T4 HNSCC. The surgical treatment plans on the basis of PET/CT findings may be changed in approximately 22% of this group. These findings suggest that [18F]fluorodeoxyglucose-PET/CT may assist the clinician in deciding on the best therapy for the clinically N0 neck in HNSCC. Well-designed clinical trials should be performed to test the outcome of omitting neck dissection by using PET/CT.

show abstract

Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Multicenter Trial of [¹⁸F]fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Staging of Head and Neck Cancer and Negative Predictive Value and Surgical Impact in the N0 Neck: Results From ACRIN 6685

Lowe

Duan

Subramaniam

et al. 2019

JCO

View full text Add to dashboard Cite

show abstract

“…At present positron emission tomography is not routinely used in the evaluation of early stage tumors. The evidence supporting its use in staging the N0 neck is mixed, although this may change with further studies.…”

Section: Recommendationsmentioning

confidence: 99%

Surgical consensus guidelines on sentinel node biopsy (SNB) in patients with oral cancer

et al. 2019

View full text Add to dashboard Cite

Background The eighth international symposium for sentinel node biopsy (SNB) in head and neck cancer was held in 2018. This consensus conference aimed to deliver current multidisciplinary guidelines. This document focuses on the surgical aspects of SNB for oral cancer. Method Invited expert faculty selected topics requiring guidelines. Topics were reviewed and evidence evaluated where available. Data were presented at the consensus meeting, with live debate from panels comprising expert, nonexpert, and patient representatives followed by voting to assess the level of support for proposed recommendations. Evidence review, debate, and voting results were all considered in constructing these guidelines. Results/Conclusion A range of topics were considered, from patient selection to surgical technique and follow‐up schedule. Consensus was not achieved in all areas, highlighting potential issues that would benefit from prospective studies. Nevertheless these guidelines represent an up‐to‐date pragmatic recommendation based on current evidence and expert opinion.

show abstract

“…[4] Many studies have paid a lot of attention to clinical negative node. [1,9] However, few focused on these patients with clinically positive or suspected neck lymph nodes (cN+). According to our department's surgical procedure, all the patients with malignant tumors undergo oral excision of the primary tumor with adequate margins and neck dissection.…”

Section: Introductionmentioning

confidence: 99%

The assessment of the accuracy of clinical preoperative lymph node

et al. 2019

View full text Add to dashboard Cite

Purpose:The aim of the present study is to assess the accuracy of clinical preoperative lymph node and to define the degree of relation between the clinical preoperative assessment and histopathological examination in patients with head and neck cancer and cN+.Methods:This retrospective study was performed on 125 patients (85 males and 40 females) at the Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Zhengzhou University, between December 2012 and December 2014.Result:Of all the patients who underwent neck dissection, 37 were found with no neck metastasis. Positive or suspected lymph nodes were detected at computed tomography (CT) in 44 and detected at ultrasonogram diagnosis (USG) in 38 of 125 patients, and the necks were assessed as normal in 55 (44%) by both USG and CT.Conclusion:Further investigation is needed to evaluate the rates of overall survival and disease-free survival of these N0 patients with neck dissection.

show abstract

Comparison of PET/CT with conventional imaging modalities (USG, CECT) in evaluation of N0 neck in head and neck squamous cell carcinoma

Abstract: In N0 neck in head and neck squamous cell carcinoma, though FDG-PET-CT is more accurate than either USG or CECT in staging of the neck, it is not accurate enough to alter the current treatment paradigm.

Cited by 14 publications

References 26 publications

Multicenter Trial of [¹⁸F]fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Staging of Head and Neck Cancer and Negative Predictive Value and Surgical Impact in the N0 Neck: Results From ACRIN 6685

Multicenter Trial of [¹⁸F]fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Staging of Head and Neck Cancer and Negative Predictive Value and Surgical Impact in the N0 Neck: Results From ACRIN 6685

Surgical consensus guidelines on sentinel node biopsy (SNB) in patients with oral cancer

The assessment of the accuracy of clinical preoperative lymph node

Contact Info

Product

Resources

About

Comparison of PET/CT with conventional imaging modalities (USG, CECT) in evaluation of N0 neck in head and neck squamous cell carcinoma

Abstract: In N0 neck in head and neck squamous cell carcinoma, though FDG-PET-CT is more accurate than either USG or CECT in staging of the neck, it is not accurate enough to alter the current treatment paradigm.

Cited by 14 publications

References 26 publications

Multicenter Trial of [18F]fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Staging of Head and Neck Cancer and Negative Predictive Value and Surgical Impact in the N0 Neck: Results From ACRIN 6685

Multicenter Trial of [18F]fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Staging of Head and Neck Cancer and Negative Predictive Value and Surgical Impact in the N0 Neck: Results From ACRIN 6685

Surgical consensus guidelines on sentinel node biopsy (SNB) in patients with oral cancer

The assessment of the accuracy of clinical preoperative lymph node

Contact Info

Product

Resources

About

Multicenter Trial of [¹⁸F]fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Staging of Head and Neck Cancer and Negative Predictive Value and Surgical Impact in the N0 Neck: Results From ACRIN 6685

Multicenter Trial of [¹⁸F]fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Staging of Head and Neck Cancer and Negative Predictive Value and Surgical Impact in the N0 Neck: Results From ACRIN 6685