Comparison of long-term outcomes of patients with severe traumatic or hypoxic brain injuries treated with intrathecal baclofen therapy for dysautonomia

Hoarau, Xavier; E, Richer; Dehail, Patrick; Cuny, Emmanuel

doi:10.3109/02699052.2012.694564

Cited by 20 publications

(6 citation statements)

References 40 publications

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“…Long-term outcome (10-year follow-up) has also been studied in a cohort of 53 severe traumatic or hypoxic patients treated with intrathecal baclofen. A good functional recovery occurred in the traumatic group but not in the hypoxic group, which suggests that hypoxic patients tend to be less responsive to the baclofen treatment than traumatic patients [83]. Among the traumatic group, 21% patients died, 30% patients were severely disabled or in a UWS, and 49% had good recovery of consciousness.…”

Section: Baclofenmentioning

confidence: 84%

Pharmacological Treatments

2013

Handbook for Attention Deficit Hyperactivity Disorder in Adults

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We review the current state of knowledge of potentially useful drugs acting on the recovery of consciousness in severely brain-damaged patients. Exploratory and retrospective studies as well as case reports on the sporadic cases of recovery are discussed regarding pharmacological treatments such as amantadine, levodopa, bromocriptine, apomorphine, methylphenidate, zolpidem, baclofen, and lamotrigine. Potential underlying mechanisms explaining the effects of these drugs on the awakening and recovery of consciousness in this challenging population are also examined. Finally, we discuss the process of using single-subject methods to assess the off-label use of a specific medication.

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Section: Baclofenmentioning

confidence: 84%

Pharmacological Treatments

2013

Handbook for Attention Deficit Hyperactivity Disorder in Adults

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“…The clinical evaluation is often difficult, particularly when the spasms are not entirely controlled and the required doses of baclofen are high, which was the case with this patient. Hypoxic brain injury has a poorer long-time functional outcome than traumatic brain injury and tend to require higher doses of baclofen (3).…”

Section: A Case Of Pocket Fill Causing Baclofen Withdrawalmentioning

confidence: 99%

A Case of Pocket Fill Causing Baclofen Withdrawal

Wankhede

2019

Neuromodulation: Technology at the Neural Interface

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“…It can reduce the number of episodes and severity of spasms and relieve clonus, pain and muscle rigidity associated with spasms. There have been reports suggesting that intrathecal infusion of baclofen (ITB) can achieve good results in case studies [29,30]. In terms of subject numbers and study design, the evidence currently available strongly supports treatment with ITB.…”

Section: Gaba Agonistsmentioning

confidence: 99%

Treatment Progress of Paroxysmal Sympathetic Hyperactivity after Acquired Brain Injury

Feng

Zheng

Fang³

2015

Pediatr Neurosurg

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Paroxysmal sympathetic hyperactivity (PSH) is a common complication of various acquired brain injuries such as traumatic brain injury, subarachnoid hemorrhage, anoxic brain injury, intracerebral hemorrhage, and others. It is manifested by tachycardia, hypertension, tachypnea, diaphoresis, and dystonic posturing. The development of PSH can prolong hospitalization and lead to secondary brain injury and even death. Despite the awareness of the serious clinical impact, there is no consensus on diagnostic criteria. Thus, misdiagnosis and delayed recognition is very common. Most of the current treatment programs come from case reports and small case series; there are very few large-scale randomized controlled trials. Generally accepted medications are opioids, β-blockers and gabapentin (usually used in combination). However, the efficacy of these drugs has not been systematically assessed. The purpose of this review is to determine the treatment strategies and drugs commonly used for PSH at the overall level.

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Comparison of long-term outcomes of patients with severe traumatic or hypoxic brain injuries treated with intrathecal baclofen therapy for dysautonomia

Abstract: At long-term follow-up, patients with hypoxic brain injury had a poorer functional outcome than patients with traumatic brain injury with persistent symptoms of dysautonomia associated with uncontrolled hypertonia, despite the use of intrathecal baclofen.

Cited by 20 publications

References 40 publications

Pharmacological Treatments

Pharmacological Treatments

A Case of Pocket Fill Causing Baclofen Withdrawal

Treatment Progress of Paroxysmal Sympathetic Hyperactivity after Acquired Brain Injury

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