Comparison of Lipoxygenase, Cyclooxygenase, Xanthine Oxidase Inhibitory Effects and Cytotoxic Activities of Selected Flavonoids

Xue, She‐Sheng; Cheng, Jing; Ma, Wentao; Liu, Yimei; Li, Juan

doi:10.12783/dteees/gmee2017/16624

Cited by 5 publications

(2 citation statements)

References 18 publications

(17 reference statements)

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“…The asterisk (*) denotes a statistically significant difference from the control group, p<0.05. sults confirmed the observation made by other authors on luteolin potential as an anti-inflammatory agent acting through downregulation of NF-κB and subsequently downregulation of COX-2 expression. In this regard, Xue and others (Xue et al, 2017) showed that luteolin and apigenin downregulate COX-2 expression in HepG2 cells. Similar observations in the case of luteolin appeared in the paper of Hwang and others (Hwang et al, 2011).…”

Section: Discussionmentioning

confidence: 96%

“…Flavonoids are commonly found in plants and they are widely used in medicine, either as isolated compounds or in the form of extracts from plants in which they are abundantly present. Several studies had shown that flavonoids, such as apigenin and luteolin, have antioxidant, anticancer, and anti-inflammatory activities (Choi et al, 2007;Shukla & Gupta, 2010;Bouzaiene et al, 2016;Xue et al, 2017;Yan et al, 2017). Moreover, in vitro studies demonstrated that anti-inflammatory properties of luteolin may be mediated by inhibition of the nuclear factor-κB (NF-κB).…”

Section: Introductionmentioning

confidence: 99%

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The effect of luteolin 7-glucoside, apigenin 7-glucoside and Succisa pratensis extracts on NF-κB activation and α-amylase activity in HepG2 cells

2020

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The chemical composition of Succisa pratensis is not well known. The existing data indicate a substantial content of flavonoids, which include luteolin and apigenin 7-glucosides. The aim of this study was to elaborate the isolation protocol of these flavonoids from flowers and leaves of S. pratensis, to carry out their characterization, as well as evaluate the effect of S. pratensis extracts on activation of transcription factor NF-κB and α-amylase activity. The extraction protocol applied in this study allowed isolation and characterization of flavonoid fraction of S. pratensis. Their identity was confirmed by NMR spectra analysis, UV spectroscopy and electrospray ionization-tandem MS evaluation. Treatment of pancreatic α-amylase with S. pratensis extract inhibited this enzyme’s activity to an extent comparable to that of isolated luteolin and apigenin 7-glucosides. Incubation of HepG2 cells for 24 h with S. pratensis extracts or isolated flavonoids resulted in moderate reduction in NF-κB transcription factor activation evaluated in terms of translocation of its active subunits from cytosol into nucleus and subsequently diminished expression of the COX-2 gene. Expression of NF-κB was also reduced. The most significantly diminished NF-κB activation and expression, as well as COX-2 expression, was found to result from treatment with isolated flavonoids and ethyl acetate extract of S. pratensis leaves. These results indicate that S. pratensis flavonoids may modulate the metabolic and signaling pathways whose deregulation is related to pathogenesis of liver cancer. Further studies are required to confirm these observations and assess the chemopreventive and/or therapeutic potential of the S. pratensis herb.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

The effect of luteolin 7-glucoside, apigenin 7-glucoside and Succisa pratensis extracts on NF-κB activation and α-amylase activity in HepG2 cells

2020

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Structural analysis and molecular docking study of pachypodostyflavone: A potent anti-onchocerca

Mountessou

Ngouonpe

Mbobda

et al. 2023

Journal of Molecular Structure

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Apigenin Bioisosteres: Synthesis and Evaluation of their Antioxidant, Antimicrobial, and Anticancer Activities

Gupta,

Thombre,

Gupta

et al. 2024

LOC

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A novel series of Apigenin bioisosteres [1(4-chlorophenyl)-3-phenyl prop-2-ene-1-one] non-cyclic derivatives (4a-4c) and [7-hydroxy-2-phenyl-4H-chromen-4-one] cyclic derivatives (9a- 9d) were synthesized. The newly synthesized apigenin bioisosteres were confirmed using UV, IR, NMR, and mass spectroscopic methods. The antioxidant, antibacterial, and anti-cancer activities of all newly synthesized compounds were assessed using the DPPH free radical scavenging capacity, disc diffusion method, and in vitro MTT assay on the human breast cancer MCF-7 cell line. Almost all the synthesized apigenin bioisosteres had greater antioxidant and antimicrobial activity than standard Apigenin. Out of seven compounds (4a-4c and 9a-9d), five compounds were found to exhibit notable antiproliferative activity on the breast cancer cell line (MCF-7), whereas two compounds, 9c and 9d, did not show notable activity. Our analysis suggests that synthesized Apigenin bioisosteres function as prospective antioxidant, antimicrobial, and anticancer agents.

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Comparison of Lipoxygenase, Cyclooxygenase, Xanthine Oxidase Inhibitory Effects and Cytotoxic Activities of Selected Flavonoids

Cited by 5 publications

References 18 publications

The effect of luteolin 7-glucoside, apigenin 7-glucoside and Succisa pratensis extracts on NF-κB activation and α-amylase activity in HepG2 cells

The effect of luteolin 7-glucoside, apigenin 7-glucoside and Succisa pratensis extracts on NF-κB activation and α-amylase activity in HepG2 cells

Structural analysis and molecular docking study of pachypodostyflavone: A potent anti-onchocerca

Apigenin Bioisosteres: Synthesis and Evaluation of their Antioxidant, Antimicrobial, and Anticancer Activities

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