Apigenin Bioisosteres: Synthesis and Evaluation of their Antioxidant, Antimicrobial, and Anticancer Activities
Juhi Gupta,
Kalyani Thombre,
Krishna Gupta
et al.
Abstract:A novel series of Apigenin bioisosteres [1(4-chlorophenyl)-3-phenyl prop-2-ene-1-one]
non-cyclic derivatives (4a-4c) and [7-hydroxy-2-phenyl-4H-chromen-4-one] cyclic derivatives (9a-
9d) were synthesized. The newly synthesized apigenin bioisosteres were confirmed using UV, IR,
NMR, and mass spectroscopic methods. The antioxidant, antibacterial, and anti-cancer activities of all
newly synthesized compounds were assessed using the DPPH free radical scavenging capacity, disc
diffusion method, and in vitro MTT ass… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.