Comparison of Hantaan and Seoul viral infections among patients with hemorrhagic fever with renal syndrome (HFRS) in Heilongjiang, China

Zhang, Xin; Chen, Huanyong; Zhū, Lìyǐng; Linglan, Zeng; Wang, Fei; Li, Qinggang; Shao, Fengmin; Jiang, Hong-qi; Liu, Shijie; Ma, Yuanyuan; Zhu, Yafang; Ma, Yanhong

doi:10.3109/00365548.2011.566279

Cited by 28 publications

(26 citation statements)

References 16 publications

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“…28 This occurs because the commercial immunological test kits to identify hantaviruses do not discriminate between the HTNV and SEOV antigens. 5 Although segregating the viral ecologies is problematic at present, making assumptions about the effects of climate on HFRS with no due consideration of the two separate viruses can be misleading at best and erroneous at worst.…”

Section: Discussionmentioning

confidence: 99%

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Transmission of Haemorrhagic Fever with Renal Syndrome in China and the Role of Climate Factors: A Review

Hansen

Cameron

Liu

et al. 2015

International Journal of Infectious Diseases

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Haemorrhagic fever with renal syndrome (HFRS) is a rodent-borne disease that poses a serious public health threat in China. HFRS is caused by hantaviruses, mainly Seoul virus in urban areas and Hantaan virus in agricultural areas. Although preventive measures including vaccination programs and rodent control measures have resulted in a decline in cases in recent years, there has been an increase in incidence in some areas and new endemic areas have emerged. This review summarises the recent literature relating to the effects of climatic factors on the incidence of HFRS in China and discusses future research directions. Temperature, precipitation and humidity affect crop yields, rodent breeding patterns and disease transmission, and these can be influenced by a changing climate. Detailed surveillance of infections caused by Hantaan and Seoul viruses and further research on the viral agents will aid in interpretation of spatiotemporal patterns and a better understanding of the environmental and ecological drivers of HFRS amid China's rapidly urbanising landscape and changing climate.

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Section: Discussionmentioning

confidence: 99%

“…[2][3][4] The five clinical stages of HFRS are: febrile, hypotensive, oliguric, diuretic, and convalescent. 5 The fatality rate in the 1960s was around 14% 6 but has since fallen due to advances in treatment. Those who survive the disease can develop chronic renal impairments.…”

Section: Introductionmentioning

confidence: 99%

Transmission of Haemorrhagic Fever with Renal Syndrome in China and the Role of Climate Factors: A Review

Hansen

Cameron

Liu

et al. 2015

International Journal of Infectious Diseases

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“…PUUV is considered to cause only mild or subclinical illness. A large Chinese study of the different clinical characteristics of HTNV and SEOV infections found a significantly higher mortality rate and a higher requirement for dialysis in the HTNV group 7. Interestingly however, they found that patients with SEOV infection had a longer duration of fever and were more likely to have liver enzyme derangement, sometimes even in the absence of AKI.…”

Section: Discussionmentioning

confidence: 98%

Hantavirus: an infectious cause of acute kidney injury in the UK

et al. 2014

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We present a case of an undifferentiated febrile illness in a 59-year-old man from East Yorkshire. He was initially treated for leptospirosis due to the fact that he had farm exposure and the findings of acute kidney injury (AKI), thrombocytopenia and a raised alanine transferase (ALT) on his initial blood results. Serology tests later proved him to have had another rodent-borne illness: hantavirus. An investigation by Public Health England (formerly known as Health Protection Agency) (PHE) went on to prove the presence of the same serotype of hantavirus in rats caught on the patient's property. After an initial deterioration, the patient made a relatively uneventful recovery and all his blood tests returned to normal levels.

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“…Frequency of abdominal pain was 47.7%–86% in HFRS patients and there is a report that all patients infected HTNV and SEOV complained of at least one of the gastrointestinal symptoms: abdominal pain, nausea, vomiting, and diarrhea. 18, 20–22 Consequently, it has been suggested that the clinical diagnosis of HFRS should be based on the triad of fever, renal insufficiency, and gastrointestinal symptoms. 18 In our study, 29 (82.9%) patients complained at least one gastrointestinal symptom including abdominal pain, abdominal discomfort, nausea, vomiting, and diarrhea.…”

Section: Discussionmentioning

confidence: 99%

Clinical and molecular epidemiological features of hemorrhagic fever with renal syndrome in Korea over a 10-year period

Noh

Cheong

Song

et al. 2013

Journal of Clinical Virology

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Background Laboratory diagnosis of hemorrhagic fever with renal syndrome (HFRS), an infectious disease caused by rodent-borne hantaviruses in Asia and Europe, depends primarily on serological methods. Since the advent of such serodiagnostic tests, few reports are available about the clinical and molecular epidemiological features of HFRS. Objectives To investigate the epidemioclinical features of HFRS treated at a tertiary-care teaching hospital in Seoul over a 10-year period. Study design Medical records of HFRS patients, visited to a tertiary-care teaching hospital during February 2002 to February 2012, were reviewed. Sera from patients were tested for Hantaan virus (HTNV) and Seoul virus (SEOV) RNA using RT-PCR. Results Among 35 HFRS patients (mean age was 44.2 ± 14.7 years), 29 were male (82.9%). Acute renal failure developed in 27 patients (77.1%), and 12 patients (34.3%) were admitted to the intensive care unit (ICU). Conjunctival injection (OR 10.32, 95% CI 1.09–97.77, P = .04) and initial serum albumin less than 3 g/dL (OR 22.83, 95% CI 1.45–359.93, P = .03) were risk factors for ICU admission. Of 35 acute-phase sera, 11 (31.4%) were positive for HTNV RNA. None were positive for SEOV RNA. Conclusions HFRS was characterized by the clinical triad of fever, renal insufficiency and gastrointestinal symptoms. Conjunctival injection and serum albumin level were related to severity. Large scaled multi-center study is needed to enhance an insight to epidemioclinical characteristics of HFRS in Korea.

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Comparison of Hantaan and Seoul viral infections among patients with hemorrhagic fever with renal syndrome (HFRS) in Heilongjiang, China

Abstract: Clinical manifestations of SEOV infection appear to be milder and less typical than HTNV. This information may help us to improve the diagnosis of SEOV-infected patients.

Cited by 28 publications

References 16 publications

Transmission of Haemorrhagic Fever with Renal Syndrome in China and the Role of Climate Factors: A Review

Transmission of Haemorrhagic Fever with Renal Syndrome in China and the Role of Climate Factors: A Review

Hantavirus: an infectious cause of acute kidney injury in the UK

Clinical and molecular epidemiological features of hemorrhagic fever with renal syndrome in Korea over a 10-year period

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