Transmission of Haemorrhagic Fever with Renal Syndrome in China and the Role of Climate Factors: A Review

Hansen, Alana; Cameron, Scott; Liu, Qiyong; Sun, Yehuan; Weinstein, Philip; Williams, Craig R.; Han, Gil‐Soo; Bi, Peng

doi:10.1016/j.ijid.2015.02.010

Cited by 53 publications

(44 citation statements)

References 28 publications

(139 reference statements)

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“…HTNV was isolated for the first time in 1978 62 and was linked to the rodent Apodemus agrarius; the virus was detected in blood, urine, feces, and respiratory tract samples. In humans, this species causes a severe form of HFRS, which has thus far been restricted to rural areas of China, Korea, and Russia 63,64 .…”

Section: Hantavirus (Hv)mentioning

confidence: 99%

Synanthropic rodents as virus reservoirs and transmitters

Gravinatti

Barbosa

Soares

et al. 2020

Rev. Soc. Bras. Med. Trop.

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This review focuses on reports of hepatitis E virus, hantavirus, rotavirus, coronavirus, and arenavirus in synanthropic rodents (Rattus rattus, Rattus norvegicus, and Mus musculus) within urban environments. Despite their potential impact on human health, relatively few studies have addressed the monitoring of these viruses in rodents. Comprehensive control and preventive activities should include actions such as the elimination or reduction of rat and mouse populations, sanitary education, reduction of shelters for the animals, and restriction of the access of rodents to residences, water, and food supplies.

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Section: Hantavirus (Hv)mentioning

confidence: 99%

Synanthropic rodents as virus reservoirs and transmitters

Gravinatti

Barbosa

Soares

et al. 2020

Rev. Soc. Bras. Med. Trop.

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“…Hemorrhagic fever with renal syndrome, caused by Hantaviruses (family Bunyaviridae) is an acute interstitial nephropathy characterized by high fever and varying degrees of renal insufficiency and hemorrhage [ 1 ]. HFRS includes diseases such as Korean hemorrhagic fever, epidemic hemorrhagic fever, and nephropathia epidemica.…”

Section: Introductionmentioning

confidence: 99%

Changes of HFRS Incidence Caused by Vaccine Intervention in Yichun City, China, 2005–2013

et al. 2016

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BackgroundSince 2009, the Hemorrhagic Fever with Renal Syndrome (HFRS) Targeted Expanded Program on Immunization (EPI) has been carried out in the 16–60 age population in Yichun City of Jiangxi Province. However, the annual reported incidences of HFRS in Yichun City Increased significantly from 2009 to 2013.Material/MethodsThe information on HFRS reported cases were obtained from the China Information System for Disease Control and Prevention (CISDCP), and demographic data was collected from the Basic Information System. Hantavirus-specific antigen and antibody of rodent specimens were tested by enzyme-linked immunosorbent assay (ELISA) or immune fluorescent assay.ResultsThe annual HFRS incidences among all age subgroups presented growth tendencies in non-EPI targeted regions and EPI targeted regions, except for the EPI target population. The annual incidences of EPI target population were stable at around 10 per 100,000 population from 2008 to 2013. HFRS annual incidence was significantly related to rat virus index among all age subgroups in non-EPI targeted regions and >60 age subgroup in EPI targeted regions.ConclusionsHFRS vaccine implement has had a notable effect in HFRS prevention and control.

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“…The genome of HTNV consists of L, M, and S segments, which encode the viral RNA-dependent RNA polymerase, glycoprotein, and nucleoprotein, respectively (Cheng et al, 2014). HFRS is a severe, life-threatening illness characterized by fever, hemorrhage, and renal failure and is a serious public health threat in China (Hansen et al, 2015). A total of 136,012 cases were reported during 2005–2015 in mainland China, with a case-fatality rate as high as 10–15% (Zhang et al, 2010; Kang et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Screening and Identification of an H-2Kb-Restricted CTL Epitope within the Glycoprotein of Hantaan Virus

Cheng

Ying

et al. 2016

Front. Cell. Infect. Microbiol.

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The cytotoxic T lymphocyte (CTL) response plays a key role in controlling viral infection, but only a few epitopes within the HTNV glycoprotein (GP) that are recognized by CTLs have been reported. In this study, we identified one murine HTNV GP-derived H2-Kb-restricted CTL epitope in C57BL/6 mice, which could be used to design preclinical studies of vaccines for HTNV infection. First, 15 8-mer peptides were selected from the HTNV GP amino acid sequence based on a percentile rank of <=1% by IEDB which is the most comprehensive collection of epitope prediction and analysis tool. A lower percentile rank indicates higher affinity and higher immune response. In the case of the consensus method, we also evaluated the binding score of peptide-binding affinity by the BIMAS software to confirm that all peptides were able to bind H2-Kb. Second, one novel GP-derived CTL epitope, GP6 aa456-aa463 (ITSLFSLL), was identified in the splenocytes of HTNV-infected mice using the IFN-γ ELISPOT assay. Third, a single peptide vaccine was administered to C57BL/6 mice to evaluate the immunogenic potential of the identified peptides. ELISPOT and cell-mediated cytotoxicity assays showed that this peptide vaccine induced a strong IFN-γ response and potent cytotoxicity in immunized mice. Last, we demonstrated that the peptide-vaccinated mice had partial protection from challenge with HTNV. In conclusion, we identified an H2-Kb-restricted CTL epitope with involvement in the host immune response to HTNV infection.

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Transmission of Haemorrhagic Fever with Renal Syndrome in China and the Role of Climate Factors: A Review

Cited by 53 publications

References 28 publications

Synanthropic rodents as virus reservoirs and transmitters

Synanthropic rodents as virus reservoirs and transmitters

Changes of HFRS Incidence Caused by Vaccine Intervention in Yichun City, China, 2005–2013

Screening and Identification of an H-2Kb-Restricted CTL Epitope within the Glycoprotein of Hantaan Virus

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