Comparison of Glycated Hemoglobin Levels in Individuals Without Diabetes and With and Without Periodontitis Before and After Non‐Surgical Periodontal Therapy

Perayil, Jayachandran; Suresh, Neethu; Fenol, Angel; Vyloppillil, Rajesh; Bhaskar, Anuradha; Menon, Saimegha

doi:10.1902/jop.2014.130661

Cited by 28 publications

(36 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In accordance with our result, Perayil et al[26] in 2014, have reported that there was significant reduction in the HbA1c levels after NSPT in non diabetic individuals with periodontitis. The mean reduction in HbA1c levels obtained in the current study is comparable to the reduction reported by them.…”

Section: Discussionsupporting

confidence: 93%

“…This observation connotes to the fact that, the average pocket depth had reduced to < 3 mm after NSPT and there by the overall surface area of the pocket lining which acts as a reservoir for periodontal pathogen and inflammatory markers had also reduced. This finding was in accordance with previous studies where significant pocket depth reduction had been observed after NSPT in non diabetic and diabetic patients[25,26]. In control group there was an increase in probing pocket depth and clinical attachment level.…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Nonsurgical periodontal-therapy improves glycosylated hemoglobin levels in pre-diabetic patients with chronic periodontitis

Joseph

Sasikumar

Mammen

et al. 2017

WJD

View full text Add to dashboard Cite

AIMTo evaluate the effect of nonsurgical periodontal therapy on glycosylated haemoglobin levels in pre-diabetic patients with chronic periodontitis (CHP).METHODSSixty pre-diabetic patients with CHP were selected and equally allocated to case and control group. All subjects were evaluated at base line for periodontal parameters (plaque index, oral hygiene index, modified gingival index, probing pocket depth, clinical attachment level) and systemic parameters [glycosylated hemoglobin (HbA1c), fasting lipid profile, and fasting blood glucose]. The case group received non-surgical periodontal therapy. Subjects were re-evaluated for periodontal and systemic parameters after three months.RESULTSBoth groups were comparable at baseline. Three months after non surgical periodontal therapy (NSPT), there was significant improvement in periodontal parameters in case group. The mean difference in systemic parameters like HbA1c and fasting plasma glucose from baseline to fourth month for case group was 0.22 ± 0.11 and 3.90 ± 8.48 respectively and control group was -0.056 ± 0.10 and -1.66 ± 6.04 respectively, which was significant between case and control group (P < 0.05). In the case group there was a significant decrease in HbA1c from baseline to three months following NSPT (P < 0.05).CONCLUSIONThis study showed that periodontal inflammation could affect the glycemic control in otherwise systemically healthy individuals. Periodontal therapy improved periodontal health status and decreased glycosylated haemoglobin levels, thus reducing the probability of occurrence of inflammation induced prediabetes in patients with CHP.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Nonsurgical periodontal-therapy improves glycosylated hemoglobin levels in pre-diabetic patients with chronic periodontitis

Joseph

Sasikumar

Mammen

et al. 2017

WJD

View full text Add to dashboard Cite

show abstract

“…This favors the explanation of the link between these two chronic diseases. Recently, studies have reported that nonsurgical periodontal treatment was sufficient to reverse even a prediabetes condition to a healthy state in a large proportion of the participants 34,35…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, individuals in our study had BMI values slightly less than overweight. It has been shown that nonobese individuals tend to show more decrease in HbA1c levels than obese individuals, as pronounced obesity masks the decrease in inflammatory response by periodontal therapy 34,44. The differences in study design may explain the variations in results in moderately controlled diabetic patients.…”

Section: Discussionmentioning

confidence: 99%

Effects of nonsurgical periodontal therapy in patients with moderately controlled type 2 diabetes mellitus and chronic periodontitis in Nepalese population

Goel

Pradhan

Bhattarai

2017

CCIDE

View full text Add to dashboard Cite

ObjectivesDespite several investigations, evidence is still controversial regarding the effect of periodontal treatment on diabetes. This study evaluates and compares the effect on glycemic control and periodontal status with or without nonsurgical periodontal therapy in patients with type 2 diabetes mellitus and chronic periodontitis in a Nepalese population.Materials and methodsA total of 82 patients attending the diabetes clinic and fulfilling enrollment criteria with moderate to severe periodontitis were selected. They were assigned in an alternative sequence, into test and control group. Both groups were instructed to continue with their medical treatment without modifications. Scaling and root surface debridement were performed in the test group whereas the control group received oral hygiene instructions with no treatment during the 3-month study period.ResultsThere were 41 participants in each group with the mean age of 50.66±7.70 and 53.80±9.16 years, average diabetes duration of 6.32±4.21 and 6.24±4.00 years, mean body mass index of 24.78±1.85 and 24.6±1.79 kg/m2, and glycated hemoglobin (HbA1c) level of 6.71±0.50% and 6.80±0.45%, in the test and control group, respectively. After 3 months, there was significant reduction in HbA1c levels in the test group compared to the control group (p=0.029). Clinical periodontal parameters of gingival index, probing depth (PD), and clinical attachment level (CAL) significantly improved in the test group (p<0.001) with PD reduction by 0.9 mm and gain in CAL by 0.3 mm compared to the control group (p>0.001) who showed an increase by 0.05 mm.ConclusionThis study showed that nonsurgical periodontal therapy may have a beneficial effect on HbA1c level in moderately controlled type 2 diabetic patients.

show abstract

“…For instance, in 35 to 65 years old individuals with prediabetes, the HbA 1c level decreased significantly 3 months after nonsurgical periodontal treatment, namely from 6.08(AE0.23)% to 5.67(AE0.33)%. 70 Another small study of persons between 35 and 75 years old with prediabetes reported a clinically and statistically significant decrease in HbA 1c level 3 months after nonsurgical periodontal treatment, namely, from 6.08(AE0.51)% to 5.89(AE0.45)%. 71 Finally, among 66 persons with prediabetes, the HbA 1c level improved from an average of 6.0% (5.7%-6.3%) to 5.1% (4.9%-5.3%) in the 33 who received nonsurgical periodontal therapy only and from 6.2% (5.7%-6.4%) to 5% (4.8%-5.3%) in participants who additionally received oral doxycycline.…”

Section: Periodontal Treatment In Prediabetes: Effects On Blood Glucomentioning

confidence: 98%

Does Treatment of Periodontal Disease Influence Systemic Disease?

Borgnakke

2015

Dental Clinics of North America

View full text Add to dashboard Cite

Comparison of Glycated Hemoglobin Levels in Individuals Without Diabetes and With and Without Periodontitis Before and After Non‐Surgical Periodontal Therapy

Abstract: The HbA1c levels of individuals without diabetes and with periodontitis (group B) were significantly reduced 3 months after non-surgical periodontal therapy, although they never reached the same levels as those of the individuals without diabetes or periodontitis (group A).

Cited by 28 publications

References 35 publications

Nonsurgical periodontal-therapy improves glycosylated hemoglobin levels in pre-diabetic patients with chronic periodontitis

Nonsurgical periodontal-therapy improves glycosylated hemoglobin levels in pre-diabetic patients with chronic periodontitis

Effects of nonsurgical periodontal therapy in patients with moderately controlled type 2 diabetes mellitus and chronic periodontitis in Nepalese population

Does Treatment of Periodontal Disease Influence Systemic Disease?

Contact Info

Product

Resources

About