Does Treatment of Periodontal Disease Influence Systemic Disease?

Borgnakke, Wenche S.

doi:10.1016/j.cden.2015.06.007

Cited by 61 publications

(53 citation statements)

References 163 publications

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“…Periodontal diseases (PDs) are common and highly prevalent chronic diseases worldwide (Marcenes et al 2013, Richards 2013, Kassebaum et al 2014, Eke et al 2015 and are known to impair systemic health in susceptible individuals with for instance metabolic, atherosclerotic cardiovascular, and rheumatoid diseases, as well as aspiration pneumonia (Chapple & Genco 2013, Linden et al 2013, Tonetti & Van Dyke 2013, Borgnakke 2015. Despite their high prevalence and evident impact on general health, PDs are commonly regarded as "silent diseases" since patients often live with no or few symptoms (i.e.…”

mentioning

confidence: 99%

Are periodontal diseases really silent? A systematic review of their effect on quality of life

Buset

Walter

Friedmann³

et al. 2016

J Clinic Periodontology

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mentioning

confidence: 99%

Are periodontal diseases really silent? A systematic review of their effect on quality of life

Buset

Walter

Friedmann³

et al. 2016

J Clinic Periodontology

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236

238

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“…1–6 There are several mechanisms underlying the association with systemic illnesses, as have been previously reviewed and summarized. 1, 2 Periodontitis, a common bacteria-induced oral inflammatory condition that destabilizes the tooth structural support apparatus, can produce transient bacteremia, which may lead to systemic endothelial dysfunction and chronic inflammatory responses in various extra-oral tissues. 7–9 Second, inflammatory markers generated from the affected periodontal tissue can also travel via the bloodstream to reach other tissue beds.…”

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confidence: 99%

Prospective Study of Oral Health and Risk of Primary Open-Angle Glaucoma in Men

et al. 2016

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Purpose Tooth loss or periodontal disease is associated with systemic endothelial dysfunction, which has been implicated in primary open-angle glaucoma (POAG). The relationship between oral health and POAG has received limited attention. Thus, we evaluated the association between oral health history and risk of POAG and POAG subtypes. Design Prospective cohort study Participants Health Professionals Follow-up Study participants (40,536 men) followed biennially from 1986 to 2012. At each 2-year risk period, eligible participants were 40+ years old, free of POAG, and reported eye examinations. Methods Using validated questions, we updated participants' status on number of natural teeth, teeth lost, periodontal disease with bone loss and root canal treatments. Main Outcome Measures During follow-up, 485 incident cases of POAG were confirmed with medical records and classified into subtypes defined by intraocular pressure (IOP) (≥ or < 22 mm Hg) or by visual field (VF) loss pattern at diagnosis (peripheral loss only or early paracentral loss). Multivariable relative risks (MVRR) and 95% confidence intervals (CIs) were estimated. Results Number of natural teeth, periodontal disease or root canal treatment were not associated with POAG. However, compared to no report of tooth loss, a report of losing teeth within the past 2 years was associated with a 1.45 fold increased risk of POAG (95% CI=1.06, 1.97); in particular, a report within the past 2 years of both losing teeth and having a prevalent diagnosis of periodontal disease was associated with 1.85 fold increased risk of POAG (95% CI=1.07, 3.18). The associations with recent tooth loss was not significantly different for the POAG subtypes (p for heterogeneity ≥ 0.36), although associations were strongest in relation to the POAG subtypes with IOP < 22 mm Hg (MVRR = 1.93, 95% CI=1.09, 3.43) and with early paracentral VF loss (MVRR = 2.27, 95% CI=1.32, 3.88). Conclusion While the number of natural teeth was not associated with risk of POAG, recent tooth loss was associated with an increased risk of POAG. Because these findings may be due to chance, they need confirmation in larger studies.

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“…Periodontal disease is the consequence of a shift in oral microbiota population from a symbiotic to a dysbiotic microbial community in the mouth. Periodontal disease begins when some factors that promote the growth of selected symbiotic bacteria, induce host inlammatory pathways [40,41]. Periodontitis not only severely deteriorates people's quality of life by impairing the dentition but also adversely afect systemic health.…”

Section: Periodontitismentioning

confidence: 99%

“…Periodontal treatment showed a beneicial efect on metabolic control of type 2 diabetic patients. Other various systemic diseases such as diabetes, cardiac disease, low birth weight, renal diseases, metabolic Role of Neutrophils in Disease Pathogenesissyndrome, obesity, Parkinson's disease, and Alzheimer's disease have been also proposed to be linked with periodontal disease on the basis of systemic inlammation [40,41,45].…”

Section: Periodontitismentioning

confidence: 99%

Neutrophil Role in Periodontal Disease

Rosales¹,

Uribe‐Querol²

2017

Role of Neutrophils in Disease Pathogenesis

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Oral tissues are constantly exposed to damage from the mechanical efort of eating and from the invasion of foreign microorganisms such as bacteria, fungi, and virus. In healthy oral tissues, there is a balance between symbiotic bacteria and cells from the innate immune system, mainly neutrophils. When this balance is broken, inlammation appears and more immune cells are recruited to the gingiva. Neutrophils form a barrier against dysbiotic bacteria. However, when neutrophils are insuicient, bacteria thrive causing periodontitis, a chronic inlammatory disease that destroys the tooth-supporting tissues or periodontium. Damage of periodontal tissues leads to tooth loss, and in severe cases, it can also afect systemic health by increasing a person's risk for atherosclerosis, rheumatoid arthritis, diabetes, and even cancer. The mechanisms neutrophil employ to keep a balance with bacteria in order to maintain healthy oral tissues is the focus of this chapter. We discuss how neutrophil antimicrobial functions keep bacteria at check and how some dysbiotic bacteria block neutrophils to promote an inlammatory state. Also, novel therapeutic approaches for periodontitis are discussed.

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Does Treatment of Periodontal Disease Influence Systemic Disease?

Cited by 61 publications

References 163 publications

Are periodontal diseases really silent? A systematic review of their effect on quality of life

Are periodontal diseases really silent? A systematic review of their effect on quality of life

Prospective Study of Oral Health and Risk of Primary Open-Angle Glaucoma in Men

Neutrophil Role in Periodontal Disease

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