Comparison of foetal metabolic differentiation in three cattle muscles

Gagnière, Hélène; Picard, Brigitte; Jurie, Catherine; Geay, Y.

doi:10.1051/rnd:19990143

Cited by 13 publications

(11 citation statements)

References 24 publications

(26 reference statements)

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“…An increase in the proportion of I fibres was observed during the first 4 or 8 postnatal weeks in sheep [90] and pigs [18,45], respectively. In bovines, this occurs during the last third of gestation [30,63]. Overall in mixed muscles of mammals, an increase in type IIB and IIX fibres is observed during postnatal growth together with a decrease of type IIA fibres.…”

Section: Contractile Differentiationmentioning

confidence: 96%

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Muscle fibre ontogenesis in farm animal species

et al. 2002

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Section: Contractile Differentiationmentioning

confidence: 96%

“…In bovines, oxidative and glycolytic enzyme activities increase during the last third of gestation (Fig. 9B) [30,38]. Fibres can be distinguished on their metabolic properties from 210 days of foetal life [30,71].…”

Section: Metabolic Differentiationmentioning

confidence: 99%

Muscle fibre ontogenesis in farm animal species

et al. 2002

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“…An explanation for the absence of detection of mRNA within the first generation can be that primary fibres are the most advanced in their differentiation at the stages we studied. In particular, differentiation is completed at 180 dpc [25,40]. At 90 and 180 dpc, expression in ST was restricted to myotubes containing developmental MHC but not any adult MHC.…”

Section: The Location Of Myostatin Expression Within the Less Differementioning

confidence: 96%

“…Differences in the temporal pattern of myostatin expression may rely on the differential precocity of the muscles. In cattle, proliferation of muscle cells occurs during the first two trimesters of gestation, whereas their contractile and metabolic differentiations occur in the last trimester [25,40]. However, muscles display a variability in the kinetics of differentiation.…”

Section: Differential Expression Between Developing Muscles Accordingmentioning

confidence: 99%

Location of myostatin expression during bovine myogenesis in vivo and in vitro

et al. 2003

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-Mutations in the myostatin gene lead to double-muscling in cattle indicating that it is a negative regulator of the total number of muscle fibres. Myostatin expression was analysed by RT-PCR in three developing bovine muscles. It decreased during differentiation in Semitendinosus and Biceps femoris, and increased in the late differentiating Masseter during gestation. A combination of in situ hybridisation and immuno-histochemical detection of myosin heavy chains (MHC) allowed us to locate the expression in myofibres containing only developmental MHC at different stages and in fast IIA fibres at the end of gestation. In vitro, myostatin was undetectable during proliferation, peaked at the onset of fusion and decreased during terminal differentiation. It was not detected in myotubes by in situ hybridisation. The inhibition of differentiation by BrdU prevented the decrease in expression. Our results show that the peak in myostatin expression coincides with early differentiation indicating a regulatory role in cattle myogenesis. myostatin [GDF8] / cattle / myogenesis / myoblast culture / in situ hybridisation

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“…Consequently, the contractile maturation of muscles in cattle, like in sheep (Maier et al, 1992) and humans (Shrager et al, 2000), but unlike in rodents (Cho et al, 1994), is particularly advanced at birth. During the last trimester, there is also a marked increase in the activities of enzymes from glycolytic and oxidative metabolism in cattle muscles (Gagniè re et al, 1999b). In cattle, all future type I myofibres exhibit an oxidative metabolism from 210 dpc.…”

Section: Cellular Events Triggering Myogenesismentioning

confidence: 99%

Ontogenesis of muscle and adipose tissues and their interactions in ruminants and other species

Bonnet

Cassar-Malek

Chilliard

et al. 2010

Animal

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The lean-to-fat ratio, that is, the relative masses of muscle and adipose tissue, is a criterion for the yield and quality of bovine carcasses and meat. This review describes the interactions between muscle and adipose tissue (AT) that may regulate the dynamic balance between the number and size of muscle v. adipose cells. Muscle and adipose tissue in cattle grow by an increase in the number of cells (hyperplasia), mainly during foetal life. The total number of muscle fibres is set by the end of the second trimester of gestation. By contrast, the number of adipocytes is never set. Number of adipocytes increases mainly before birth until 1 year of age, depending on the anatomical location of the adipose tissue. Hyperplasia concerns brown pre-adipocytes during foetal life and white pre-adipocytes from a few weeks after birth. A decrease in the number of secondary myofibres and an increase in adiposity in lambs born from mothers severely underfed during early pregnancy suggest a balance in the commitment of a common progenitor into the myogenic or adipogenic lineages, or a reciprocal regulation of the commitment of two distinct progenitors. The developmental origin of white adipocytes is a subject of debate. Molecular and histological data suggested a possible transdifferentiation of brown into white adipocytes, but this hypothesis has now been challenged by the characterization of distinct precursor cells for brown and white adipocytes in mice. Increased nutrient storage in fully differentiated muscle fibres and adipocytes, resulting in cell enlargement (hypertrophy), is thought to be the main mechanism, whereby muscle and fat masses increase in growing cattle. Competition or prioritization between adipose and muscle cells for the uptake and metabolism of nutrients is suggested, besides the successive waves of growth of muscle v. adipose tissue, by the inhibited or delayed adipose tissue growth in bovine genotypes exhibiting strong muscular development. This competition or prioritization occurs through cellular signalling pathways and the secretion of proteins by adipose tissue (adipokines) and muscle (myokines), putatively regulating their hypertrophy in a reciprocal manner. Further work on the mechanisms underlying cross-talk between brown or white adipocytes and muscle fibres will help to achieve better understanding as a prerequisite to improving the control of body growth and composition in cattle.

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Comparison of foetal metabolic differentiation in three cattle muscles

Cited by 13 publications

References 24 publications

Muscle fibre ontogenesis in farm animal species

Muscle fibre ontogenesis in farm animal species

Location of myostatin expression during bovine myogenesis in vivo and in vitro

Ontogenesis of muscle and adipose tissues and their interactions in ruminants and other species

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