Muscle fibre ontogenesis in farm animal species

Picard, Brigitte; Lefaucheur, Louis; Berri, Cécile; Duclos, M. J.

doi:10.1051/rnd:2002035

Cited by 329 publications

(314 citation statements)

References 88 publications

Supporting

Mentioning

273

Contrasting

Unclassified

Order By: Relevance

“…In the past decades, it has been demonstrated that tissue characteristics in postnatal life (and especially those of the muscle tissue; Picard et al, 2002) have their origins early in life. The foetal programming process determines not only the muscle mass but also its physiological properties, such as total fibre number, and likely the amount of IMF.…”

Section: How Might Marbling Begin?mentioning

confidence: 99%

Intramuscular fat content in meat-producing animals: development, genetic and nutritional control, and identification of putative markers

Hocquette

Gondret

Baéza³

et al. 2010

Animal

632

447

View full text Add to dashboard Cite

Intramuscular fat (IMF) content plays a key role in various quality traits of meat. IMF content varies between species, between breeds and between muscle types in the same breed. Other factors are involved in the variation of IMF content in animals, including gender, age and feeding. Variability in IMF content is mainly linked to the number and size of intramuscular adipocytes. The accretion rate of IMF depends on the muscle growth rate. For instance, animals having a high muscularity with a high glycolytic activity display a reduced development of IMF. This suggests that muscle cells and adipocytes interplay during growth. In addition, early events that influence adipogenesis inside the muscle (i.e proliferation and differentiation of adipose cells, the connective structure embedding adipocytes) might be involved in interindividual differences in IMF content. Increasing muscularity will also dilute the final fat content of muscle. At the metabolic level, IMF content results from the balance between uptake, synthesis and degradation of triacylglycerols, which involve many metabolic pathways in both adipocytes and myofibres. Various experiments revealed an association between IMF level and the muscle content in adipocyte-type fatty acid-binding protein, the activities of oxidative enzymes, or the delta-6-desaturase level; however, other studies failed to confirm such relationships. This might be due to the importance of fatty acid fluxes that is likely to be responsible for variability in IMF content during the postnatal period rather than the control of one single pathway. This is evident in the muscle of most fish species in which triacylglycerol synthesis is almost zero. Genetic approaches for increasing IMF have been focused on live animal ultrasound to derive estimated breeding values. More recently, efforts have concentrated on discovering DNA markers that change the distribution of fat in the body (i.e. towards IMF at the expense of the carcass fatness). Thanks to the exhaustive nature of genomics (transcriptomics and proteomics), our knowledge on fat accumulation in muscles is now being underpinned. Metabolic specificities of intramuscular adipocytes have also been demonstrated, as compared to other depots. Nutritional manipulation of IMF independently from body fat depots has proved to be more difficult to achieve than genetic strategies to have lipid deposition dependent of adipose tissue location. In addition, the biological mechanisms that explain the variability of IMF content differ between genetic and nutritional factors. The nutritional regulation of IMF also differs between ruminants, monogastrics and fish due to their digestive and nutritional particularities.

show abstract

Section: How Might Marbling Begin?mentioning

confidence: 99%

Intramuscular fat content in meat-producing animals: development, genetic and nutritional control, and identification of putative markers

Hocquette

Gondret

Baéza³

et al. 2010

Animal

632

447

View full text Add to dashboard Cite

show abstract

“…For more details see, for example, the reviews by Biressi et al (2007), Buckingham and Vincent (2009) and Relaix and Marcelle (2009). In mammals and poultry, primary fibres form first, followed by the secondary fibres that develop around these primaries (Maltin et al, 2001;Picard et al, 2002). In large mammals (e.g.…”

Section: Myogenesis and Myogenic Regulatory Factors (Mrfs)mentioning

confidence: 99%

“…sheep and pigs), tertiary fibres have also been described developing between the secondaries (Lefaucheur et al, 1995), although this is hotly debated at times. In mammals, formation of new muscle fibres takes place in utero, with the numbers of muscle fibres within each muscle thought to be set around the time of birth (see reviews by Maltin et al, 2001;Picard et al, 2002;Brameld et al, 2003;Chang, 2007;Brameld and Daniel, 2008). However, rats and mice are an exception as muscle fibre formation in some muscles continues during the early neonatal period (Rehfeldt et al, 1987;Wilson et al, 1988).…”

Section: Myogenesis and Myogenic Regulatory Factors (Mrfs)mentioning

confidence: 99%

“…The IGFs (IGF-I and IGF-II) are potent mitogens for most cell types, including myoblasts, but they also stimulate muscle cell differentiation by inducing expression of one of the MRFs, myogenin (see Florini et al, 1996;Oksbjerg et al, 2004;Codina et al, 2008). Indeed, spontaneous differentiation in cultured muscle cell lines can be inhibited by blocking local IGF-II production/action (see Florini et al, 1996), and the increased number of muscle fibres observed in double-muscled cattle is associated with a delay in both differentiation and local IGF-II expression (Gerrard and Grant, 1994), as well as mutations in the myostatin gene (see reviews by Maltin et al, 2001;Picard et al, 2002;Brameld et al, 2003;Brameld and Daniel, 2008). However, a number of other hormones, growth factors (e.g.…”

Section: Critical Timings and Mechanismsmentioning

confidence: 99%

“…However, a number of other hormones, growth factors (e.g. myostatin) and nutrients have also been shown to regulate myoblast proliferation and differentiation directly and therefore are also likely to play a role (see reviews by Maltin et al, 2001;Picard et al, 2002;Brameld et al, 2003;Brameld and Daniel, 2008) including antioxidants , soyaderived isoflavones (Mau et al, 2008a) and unsaturated fatty acids (Hurley et al, 2006; see also 'Environmental impact on skeletal muscle development and consequences for animal growth, carcass and meat quality').…”

Section: Critical Timings and Mechanismsmentioning

confidence: 99%

See 2 more Smart Citations

Advances in research on the prenatal development of skeletal muscle in animals in relation to the quality of muscle-based food. I. Regulation of myogenesis and environmental impact

Rehfeldt

Pas

Wimmers

et al. 2011

Animal

View full text Add to dashboard Cite

Skeletal muscle development in vertebrates – also termed myogenesis – is a highly integrated process. Evidence to date indicates that the processes are very similar across mammals, poultry and fish, although the timings of the various steps differ considerably. Myogenesis is regulated by the myogenic regulatory factors and consists of two to three distinct phases when different fibre populations appear. The critical times when myogenesis is prone to hormonal or environmental influences depend largely on the developmental stage. One of the main mechanisms for both genetic and environmental effects on muscle fibre development is via the direct action of the growth hormone–insulin-like growth factor (GH–IGF) axis. In mammals and poultry, postnatal growth and function of muscles relate mainly to the hypertrophy of the fibres formed during myogenesis and to their fibre-type composition in terms of metabolic and contractile properties, whereas in fish hyperplasia still plays a major role. Candidate genes that are important in skeletal muscle development, for instance, encode for IGFs and IGF-binding proteins, myosin heavy chain isoforms, troponin T, myosin light chain and others have been identified. In mammals, nutritional supply in utero affects myogenesis and the GH–IGF axis may have an indirect action through the partitioning of nutrients towards the gravid uterus. Impaired myogenesis resulting in low skeletal myofibre numbers is considered one of the main reasons for negative long-term consequences of intrauterine growth retardation. Severe undernutrition in utero due to natural variation in litter or twin-bearing species or insufficient maternal nutrient supply may impair myogenesis and adversely affect carcass quality later in terms of reduced lean and increased fat deposition in the progeny. On the other hand, increases in maternal feed intake above standard requirement seem to have no beneficial effects on the growth of the progeny with myogenesis not or only slightly affected. Initial studies on low and high maternal protein feeding are published. Although there are only a few studies, first results also reveal an influence of nutrition on skeletal muscle development in fish and poultry. Finally, environmental temperature has been identified as a critical factor for growth and development of skeletal muscle in both fish and poultry.

show abstract

Advancing Technologies for Spatial and Temporal Proteomics

Doherty¹

2011

Methods in Animal Proteomics

View full text Add to dashboard Cite

Muscle fibre ontogenesis in farm animal species

Cited by 329 publications

References 88 publications

Intramuscular fat content in meat-producing animals: development, genetic and nutritional control, and identification of putative markers

Intramuscular fat content in meat-producing animals: development, genetic and nutritional control, and identification of putative markers

Advances in research on the prenatal development of skeletal muscle in animals in relation to the quality of muscle-based food. I. Regulation of myogenesis and environmental impact

Advancing Technologies for Spatial and Temporal Proteomics

Contact Info

Product

Resources

About