Comparison of FDG PET and SPECT for Detection of Bone Metastases in Breast Cancer

Uematsu, Takayoshi; Yuen, Sachiko; Yukisawa, Seigo; Aramaki, Takeshi; Morimoto, Naoki; Endo, Masahiro; Furukawa, Hiroyoshi; Uchida, Yoshihiro; Watanabe, Junichiro

doi:10.2214/ajr.184.4.01841266

Cited by 128 publications

(58 citation statements)

References 12 publications

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“…The clinical guidelines on use of radionuclides from the American College of Cardiology and the American Heart Association [15] report that average sensitivity is 87% for detecting angiographically significant coronary artery disease, while average specificity is 73%. [16], a lesion-by-lesion analysis in 15 patients showed that SPECT was more sensitive (85%) compared to PET (17%) and the overall accuracy of SPECT was higher (96%) compared to PET (85%).…”

Section: Cardiology Pet Vs Spectmentioning

confidence: 97%

Radiotracers for SPECT imaging: current scenario and future prospects

Adak¹,

Bhalla

Raj

et al. 2012

Ract

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Summary. Single photon emission computed tomography (SPECT) has been the cornerstone of nuclear medicine and today it is widely used to detect molecular changes in cardiovascular, neurological and oncological diseases. While SPECT has been available since the 1980s, advances in instrumentation hardware, software and the availability of new radiotracers that are creating a revival in SPECT imaging are reviewed in this paper.The biggest change in the last decade has been the fusion of CT with SPECT, which has improved attenuation correction and image quality. Advances in collimator design, replacement of sodium iodide crystals in the detectors with cadmium zinc telluride (CZT) detectors as well as advances in software and reconstruction algorithms have all helped to retain SPECT as a much needed and used technology.Today, a wide spectrum of radiotracers is available for use in cardiovascular, neurology and oncology applications. The development of several radiotracers for neurological disorders is briefly described in this review, including [123 I]FP-CIT (DaTSCAN™) available for Parkinson's disease. In cardiology, while technetium-99m labeled tetrofosmin and technetium-99m labeled sestamibi have been well known for myocardial perfusion imaging, we describe a recently completed multicenter clinical study on the use of [ 123 I]mIBG (AdreView™) for imaging in chronic heart failure patients. For oncology, while bone scanning has been prevalent, newer radiotracers that target cancer mechanisms are being developed. Technetium-99m labeled RGD peptides have been reported in the literature that can be used for imaging angiogenesis, while technetium-99m labeled duramycin has been used to image apoptosis.While PET/CT is considered to be the more advanced technology particularly for oncology applications, SPECT continues to be the modality of choice and the workhorse in many hospitals and nuclear medicine centers. The cost of SPECT instruments also makes them more attractive in developing countries where the cost of a scan is still prohibitive for many patients.

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Section: Cardiology Pet Vs Spectmentioning

confidence: 97%

Radiotracers for SPECT imaging: current scenario and future prospects

Adak¹,

Bhalla

Raj

et al. 2012

Ract

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show abstract

“…Further gains in sensitivity and, especially, in specificity and diagnostic confidence were apparent with SPECT/CT (22)(23)(24)(25) because of the greater contrast resolution of SPECT coupled with the ability to reduce false-positive diagnoses of metastases through correlation with the morphologic appearance of lesions on CT.…”

Section: Bone Scintigraphy Including Spect and Spect/ctmentioning

confidence: 99%

Imaging Bone Metastases in Breast Cancer: Staging and Response Assessment

2016

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“…PET scans have limited resolutions, but fusion with CT (PET-CT) allows more precise localization of radiotracer uptake. While this modality is more sensitive and specific than SS, its role is controversial due to its increased radiation dose and high cost [27] . Currently it is only recommended if plain radiography, CT, SS, and MRI do not provide adequate information for diagnosis or treatment planning [24] .…”

Section: Treatment Modality and Tumor Evaluationmentioning

confidence: 99%

Diagnosis and surgical management of breast cancer metastatic to the spine

Yurter

Gokaslan

et al. 2014

WJCO

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Breast cancer is the most common malignancy and the second leading cause of death in Western women. Breast cancer most commonly metastasizes to the bone and has a particular affinity with the spine, accounting for 2/3 of osseous metastases discovered. With significant improvements in cancer therapies, the number of patients at risk for symptomatic spinal metastases is likely to increase. Patients may suffer from intractable pain and neurological dysfunction, negatively influencing their quality of life. Timely diagnosis of patients is crucial and has been aided by several breakthrough advances in imaging techniques which aid in detection, staging, and follow-up of bone metastases. Breast metastases are usually responsive to hormonal therapy and pharmacologic interventions, but skeletal metastases often require surgical intervention. The treatments are palliative but goals include the preserving or restoring neurologic function, ensuring spinal stability, and relieving pain. Advances in surgical techniques and instrumentation have allowed more effective decompression and stabilization of the spine, and with the support of recent evidence the trend has shifted towards using more advanced surgical options in appropriately selected patients. In this review, the clinical presentation, diagnosis, patient selection, and surgical management of breast cancer metastatic to the spine are discussed. Key words: Breast cancer; Spine; Metastasis; Surgery; Outcomes; Decompression Core tip: Breast cancer most commonly metastasizes to the bone and has a particular affinity for the spine. The treatment for symptomatic spinal metastases remains palliative and is not intended to prolong survival. Surgical advances in the last few decades have allowed improved spinal cord decompression and tumor resection. With the support of recent literature, the trend has shifted towards using more advanced surgical options in appropriately selected patients. Goals of treatment include restoration of and preservation of neurological function, maintaining spinal stability, and pain relief in an effort to achieve a better quality of life.Ju DG, Yurter A, Gokaslan ZL, Sciubba DM. Diagnosis and surgical management of breast cancer metastatic to the spine. World

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Comparison of FDG PET and SPECT for Detection of Bone Metastases in Breast Cancer

Abstract: Bone SPECT is superior to FDG PET in detecting bone metastases in breast cancer. The sensitivity of osteoblastic lesions is limited with FDG PET. Surveillance of metastatic spread to the skeleton in breast cancer patients based on FDG PET alone is not possible.

Cited by 128 publications

References 12 publications

Radiotracers for SPECT imaging: current scenario and future prospects

Radiotracers for SPECT imaging: current scenario and future prospects

Imaging Bone Metastases in Breast Cancer: Staging and Response Assessment

Diagnosis and surgical management of breast cancer metastatic to the spine

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