Comparison of Extraction Methods, Antioxidant Activities, Total Phenol in Seeds and Seed Shells of Kabau (Archidendron bubalinum (Jack) I.C. Nielsen) From Lampung and South Sumatra

Riasari, Hesti; Fitriansyah, Sani Nurlaela; Hartati, Rika; Anggadiredja, Kusnandar; Sukrasno,

doi:10.5530/pj.2019.11.198

Cited by 4 publications

(2 citation statements)

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“…The IC50 values were 273.57, 324.913, and 735 ppm, respectively, for ethyl acetate, methanol and n-hexane extract [11]. Meanwhile, our previous result [12] states that the extraction method and the difference in the place of growth affect the phenolic content and antioxidant activity. The use of maceration on the seeds and bark of kabau is better than the soxhlet method; the highest antioxidant activity and total phenol levels are found in the seeds and bark of kabau originating from South Sumatra with the maceration method.…”

Section: Introductionmentioning

confidence: 81%

In Vivo Antidiabetic Screening of Kabau (Archidendron Bubalinum (Jack) I. C Nielsen) Seeds

Riasari

Fauzi²,

Anggadiredja

et al. 2021

Int J App Pharm

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Objective: Study described the screening potential antidiabetic activity of kabau seed extract and fraction. Methods: The powdered crude drugs weighing 1349.32 grams were extracted with a solvent with solvents with escalating polarity by using soxhletation. The solvents used were n-hexane, ethyl acetate, and 96% ethanol. Screening activity using three variations on doses on the three extracts using the glucose test tolerance method, then the alloxan induction and high-fat feed induction testing methods using selected doses, decreasing blood glucose levels using the GOD PAP enzyme and decreasing MDA levels and increased levels of the enzyme SOD. Extracts that have potential antidiabetic activity are fractionated using liquid-solid fractionation; then the fraction is screened for antidiabetic activity using the glucose test tolerance method. Results: Screening for antidiabetic activity on the three extracts using the glucose test tolerance method showed that the ethanol extract at a dose of 250 mg/kg BW. The three extracts were then screened for the next mechanism using the alloxan induction method and high-fat feed induction, the decrease in blood sugar levels by the GOD-PAP method showed a good decrease in the ethanol extract by 202.94±2 mg/dl, the three extracts showed good less significant, in the SOD enzyme method, the ethanol extract gave a good value such as the positive control value. Testing on fraction can decrease in blood sugar; the results showed that the ethanol extract and methanol fraction gave a small AUC 0-150 (32695,3 and 33167,71), where the value was close to the result of the glibenclamide 30238,48. Conclusion: The antidiabetic activity of the extract showed that the ethanol extract was better with the glucose test tolerance method, with alloxan induction animal models and high-fat feed induction. In the methanol fraction derived from 96% ethanol extract, it provides a good reduction in blood sugar levels in the screening method with a glucose test tolerance

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Section: Introductionmentioning

confidence: 81%

In Vivo Antidiabetic Screening of Kabau (Archidendron Bubalinum (Jack) I. C Nielsen) Seeds

Riasari

Fauzi²,

Anggadiredja

et al. 2021

Int J App Pharm

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“…Flavonoids cause orange or yellow color changes in the amyl alcohol layer. The addition of magnesium and hydrogen chloride powder causes the reduction of flavonoids to red [25]. Flavonoids are the largest naturally occurring phenolic compounds.…”

Section: Phytochemical Screeningmentioning

confidence: 99%

Anti-Diabetic Activity of Kabau Seed Powder Suspension (Archidendron Bubalinum (Jack) I. C. Nielsen) in Alloxan-Induced Diabetic Rats

RIASARI,

FITRIANSYAH,

FAUZI

2023

Int J App Pharm

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Objective: The study was to optimize the method of test dosage form kabau seed simplicia suspension in alloxan-induced diabetic rat models. Methods: Simplisia powder sizing was carried out using three sieve sizes through meshes of 80, 120, and 200. Making a suspension of kabau seed powder is carried out using two methods, with the addition of CMC, which has been developed first and the powder is added with CMC, which is then developed and then homogenized. The study consisted of six groups, dosage given of 250, 500, and 1000 mg/kg BW. Blood glucose levels were determined by the GOD-PAP, phytochemical screening and TLC tests were carried out on the test material. The data were tested statistically using One Way ANOVA. Results: The powdered crude material with a particle size of 74 microns, obtained by sieving through a mesh size of 200, is utilized as the test material in the second method. An effective dose of 1000 mg/kg BW with a decrease in blood sugar levels by 132±13 mg/dl. Phytochemical screening contained alkaloids, flavonoids, phenolics, monoterpenes and sesquiterpenes, steroids, quinones and saponins. TLC of the test material, mobile phase used in TLC was toluene: chloroform: ethyl acetate (4:5:1), obtained 6 spots which gives a specific spot after being sprayed with the chromogenic reagent. Conclusion: powder with a particle size of 74 microns was used as the test material, using the second method. The effective dose as an antidiabetic is 1000 mg/kg BW with a reduction in blood sugar levels of 132.7±13 mg/dl.

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Comparison of Saponin Levels of Lerak Extract (Sapindus rarak) Maceration and Socletation Results Based on UV-Vis Spectrophotometry Analysis

Fitria,

Sulisetijono,

Lelitawati

et al. 2024

BIO Web Conf.

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The potential of Lerak fruit (Sapindus rarak) as a basic ingredient for medicine has been recognized because of its content, which is rich in saponin compounds. Saponin compounds are known to have antimicrobial effects, the ability to inhibit fungal growth, antidiabetic properties, and anti-inflammatory properties. To maximize the content of active compounds, optimization is required, including variations in extraction methods. This study aims to compare the levels of saponins produced by the maceration and Soxhletation extraction methods. Saponin levels were tested using the UV-Vis spectrophotometry method with standard Diosgenin. Data were analyzed using independent t-test statistics. The yield of the maceration and Soxhletation extraction methods was 70.59±0.505% and 84.71±1.956% respectively. The results of saponin levels obtained from the maceration and Soxhletation extracts were 1.395±0.005μgde/ml and 1.904±0.015 μgde/ml respectively. The statistical test results showed a significant value of 0.000, which is less than 0.05, with a 95% confidence level. The conclusion of this study was that there were significant differences in saponin levels in the macerated and soxhleted lerak extract, with the highest levels found in the Soxhletation method with levels of 1.904±0.015 μgde/ml.

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Comparison of Extraction Methods, Antioxidant Activities, Total Phenol in Seeds and Seed Shells of Kabau (Archidendron bubalinum (Jack) I.C. Nielsen) From Lampung and South Sumatra

Cited by 4 publications

References 4 publications

In Vivo Antidiabetic Screening of Kabau (Archidendron Bubalinum (Jack) I. C Nielsen) Seeds

In Vivo Antidiabetic Screening of Kabau (Archidendron Bubalinum (Jack) I. C Nielsen) Seeds

Anti-Diabetic Activity of Kabau Seed Powder Suspension (Archidendron Bubalinum (Jack) I. C. Nielsen) in Alloxan-Induced Diabetic Rats

Comparison of Saponin Levels of Lerak Extract (Sapindus rarak) Maceration and Socletation Results Based on UV-Vis Spectrophotometry Analysis

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