Comparison of exposure assessment methods in a lung cancer case-control study: performance of a lifelong task-based questionnaire for asbestos and PAHs

Bourgkard, Ève; Wild, Pascal; Gonzalez, Maria; Févotte, Joëlle; Penven, Emmanuelle; Paris, Christophe

doi:10.1136/oemed-2013-101467

Cited by 19 publications

(20 citation statements)

References 34 publications

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“…expert consensus approach and JEM) to assess occupational exposure in order to increase the robustness of our findings. Although the agreement between the two methods was moderate to good, this is consistent with published studies which have also demonstrated moderate agreement when different exposure assessment methodologies are employed [22,23]. It should be viewed as reassuring that a positive association between trichloroethylene and PVOD was demonstrated using two independent assessment tools.…”

Section: Study Limitationssupporting

confidence: 87%

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Occupational exposure to organic solvents: a risk factor for pulmonary veno-occlusive disease

et al. 2015

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Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension characterised by predominant remodelling of pulmonary venules. Bi-allelic mutations in the eukaryotic translation initiation factor 2α kinase 4 (EIF2AK4) gene were recently described as the major cause of heritable PVOD, but risk factors associated with PVOD remain poorly understood. Occupational exposures have been proposed as a potential risk factor for PVOD, but epidemiological studies are lacking.A case-control study was conducted in consecutive PVOD (cases, n=33) and pulmonary arterial hypertension patients (controls, n=65). Occupational exposure was evaluated via questionnaire interview with blinded assessments using an expert consensus approach and a job exposure matrix ( JEM).Using the expert consensus approach, PVOD was significantly associated with occupational exposure to organic solvents (adjusted OR 12.8, 95% CI 2.7-60.8), with trichloroethylene being the main agent implicated (adjusted OR 8.2, 95% CI 1.4-49.4). JEM analysis independently confirmed the association between PVOD and trichloroethylene exposure. Absence of significant trichloroethylene exposure was associated with a younger age of disease (54.8±21.4 years, p=0.037) and a high prevalence of harbouring bi-allelic EIF2AK4 mutations (41.7% versus 0%, p=0.015).Occupational exposure to organic solvents may represent a novel risk factor for PVOD. Genetic background and environmental exposure appear to influence the phenotypic expression of the disease. @ERSpublications Occupational exposure to organic solvents is a novel risk factor for pulmonary veno-occlusive disease

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Section: Study Limitationssupporting

confidence: 87%

“…Both expert consensus assessment and JEM are commonly used to evaluate occupational exposures [20,22,23]. Therefore, these two independent assessment tools were used as complementary analyses to increase the robustness of any positive associations.…”

Section: Expert Consensus Assessmentmentioning

confidence: 99%

Occupational exposure to organic solvents: a risk factor for pulmonary veno-occlusive disease

et al. 2015

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“…It included questions about demographics, socio-educative level and alternative tobacco consumption, as well as cannabis smoking, passive smoking exposure, occupational exposure, personal medical history, family history, alcohol intake and fried and stir-fried cooking exposure. Occupational exposures to bronchial carcinogens were assessed using a lifelong task-based questionnaire, the efficacy of which for detecting occupational exposure was recently published [10]. All patients were questioned about their home addresses and exposure to solid fuel for cooking or heating.…”

Section: Methodsmentioning

confidence: 99%

BioCAST/IFCT-1002: epidemiological and molecular features of lung cancer in never-smokers

et al. 2015

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Lung cancer in never-smokers (LCINS) (fewer than 100 cigarettes in lifetime) is considered as a distinct entity and harbours an original molecular profile. However, the epidemiological and molecular features of LCINS in Europe remain poorly understood.All consecutive newly diagnosed LCINS patients were included in this prospective observational study by 75 participating centres during a 14-month period. Each patient completed a detailed questionnaire about risk factor exposure. Biomarker and pathological analyses were also collected. We report the main descriptive overall results with a focus on sex differences.384 patients were included: 65 men and 319 women. 66% had been exposed to passive smoking (significantly higher among women). Definite exposure to main occupational carcinogens was significantly higher in men (35%versus8% in women). A targetable molecular alteration was found in 73% of patients (without any significant sex difference):EGFRin 51%,ALKin 8%,KRASin 6%,HER2in 3%,BRAFin 3%,PI3KCAin less than 1%, and multiple in 2%.We present the largest and most comprehensive LCINS analysis in a European population. Physicians should track occupational exposure in men (35%), and a somatic molecular alteration in both sexes (73%).

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“…Patients were surveyed using a standardised questionnaire during a pre-planned phone interview with a member of the study team. This 17-page questionnaire requested information on demographics, occupational exposure [19], exposure to domestic pollution, and personal and familial medical history, as well as some lifestyle, hormonal and reproductive factors (women only). Additional medical data were collected directly from participating physicians.…”

Section: Methodsmentioning

confidence: 99%

No impact of passive smoke on the somatic profile of lung cancers in never-smokers

Couraud¹,

Debieuvre²,

Moreau³

et al. 2015

Eur Respir J

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EGFR and HER2 mutations and ALK rearrangement are known to be related to lung cancer in never-smokers, while KRAS, BRAF and PIK3CA mutations are typically observed among smokers. There is still debate surrounding whether never-smokers exposed to passive smoke exhibit a "smoker-like" somatic profile compared with unexposed never-smokers.Passive smoke exposure was assessed in the French BioCAST/IFCT-1002 never-smoker lung cancer cohort and routine molecular profiles analyses were compiled.Of the 384 patients recruited into BioCAST, 319 were tested for at least one biomarker and provided data relating to passive smoking. Overall, 219 (66%) reported having been exposed to passive smoking. No significant difference was observed between mutation frequency and passive smoke exposure (EGFR mutation: 46% in never exposed versus 41% in ever exposed; KRAS: 7% versus 7%; ALK: 13% versus 11%; HER2: 4% versus 5%; BRAF: 6% versus 5%; PIK3CA: 4% versus 2%). We observed a nonsignificant trend for a negative association between EGFR mutation and cumulative duration of passive smoke exposure. No association was found for other biomarkers.There is no clear association between passive smoke exposure and somatic profile in lifelong, never-smoker lung cancer. @ERSpublications Never-smokers with lung cancer exposed to passive smoke do not have a smoker-like somatic mutation profile

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Comparison of exposure assessment methods in a lung cancer case-control study: performance of a lifelong task-based questionnaire for asbestos and PAHs

Abstract: Asbestos-exposure estimates based on the TBQ were consistent with the REFERENCE expertise and yielded a steeper dose-response relationship than the JEM. For PAHs, results were less clear.

Cited by 19 publications

References 34 publications

Occupational exposure to organic solvents: a risk factor for pulmonary veno-occlusive disease

Occupational exposure to organic solvents: a risk factor for pulmonary veno-occlusive disease

BioCAST/IFCT-1002: epidemiological and molecular features of lung cancer in never-smokers

No impact of passive smoke on the somatic profile of lung cancers in never-smokers

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