Occupational exposure to organic solvents: a risk factor for pulmonary veno-occlusive disease

Montani, David; Lau, Edmund; Descatha, Alexis; Jaïs, Xavier; Savale, Laurent; Andujar, Pascal; Bensefa‐Colas, Lynda; Girerd, Barbara; Zendah, I.; Pavec, Jérôme Le; Seferian, Andrei; Perros, Frédèric; Dorfmüller, Peter; Fadel, Élie; Soubrier, Florent; Sitbon, Olivier; Simonneau, Gérald; Humbert, Marc

doi:10.1183/13993003.00814-2015

Cited by 97 publications

(90 citation statements)

References 39 publications

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“…Occupational exposure to organic solvents was more frequent in men and in the older age group. The questionnaire also revealed a significantly higher tobacco exposure in PVOD compared to PAH patients (total packyears 33 ± 24.7 vs 8.0 ± 14.3 respectively) [5]. [19].…”

Section: Occupational Dependence Of Pvod/pchmentioning

confidence: 85%

“…A case control study conducted among 33 consecutive PVOD patients and 65 PAH patients as controls revealed significantly higher prevalence of occupational exposure to organic solvents in PVOD patients, compared to PAH patients (72.7% vs 27.7%, respectively). Exposure to trichloroethylene was significantly more frequent in PVOD compared to PAH (42% vs 3%, respectively) [5]. The trichloroethylene use was reported mostly by: metal workers, mechanics and repairers, building painters and cleaners.…”

Section: Occupational Dependence Of Pvod/pchmentioning

confidence: 93%

“…In 2015, Montani et al reported on the association between occupational exposure to organic solvents and PVOD [5]. A case control study conducted among 33 consecutive PVOD patients and 65 PAH patients as controls revealed significantly higher prevalence of occupational exposure to organic solvents in PVOD patients, compared to PAH patients (72.7% vs 27.7%, respectively).…”

Section: Occupational Dependence Of Pvod/pchmentioning

confidence: 99%

“…New PVOD diagnostic algorithm was proposed recently by Montani et al [5]. The authors introduced subsequent definitions:…”

Section: Recommended Pvod Diagnostic Criteriamentioning

confidence: 99%

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Pulmonary Veno-Occlusive Disease: Pathogenesis, Risk Factors, Clinical Features and Diagnostic Algorithm—State of the Art

Szturmowicz¹,

Kacprzak²,

Szołkowska³

et al. 2018

Advances in Respiratory Medicine

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Pulmonary veno-occlusive disease (PVOD) and pulmonary capillary haemangiomatosis (PCH) are rare disorders, with the estimated prevalence of less than 1 case per million inhabitants. The vascular pathology in PVOD/PCH involves pre-septal and septal veins, alveolar capillaries and small pulmonary arteries. According to the ERS/ESC classification of pulmonary hypertension (PH) from 2015, PVOD/PCH have been included in the subgroup 1' of pulmonary arterial hypertension (PAH). Recent data indicate, however, the possibility of PVOD/PCH pathology in the patients diagnosed in the group 1. The problem may concern PAH associated with scleroderma, drug-induced PAH, PAH due to HIV infection and up to 10% of patients with idiopathic PAH (IPAH). Recently, bi-allelic EIF2AK4 mutations were found in the cases with heritable form of PVOD/PCH and in about 9% of sporadic cases. Moreover, an association between occupational exposure to organic solvents and PVOD/PCH was proved. The present review is an attempt to summarise the current data on pathogenesis, risk factors, clinical features and diagnostic algorithm for PVOD/PCH.

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Section: Occupational Dependence Of Pvod/pchmentioning

confidence: 85%

Section: Occupational Dependence Of Pvod/pchmentioning

confidence: 93%

Section: Occupational Dependence Of Pvod/pchmentioning

confidence: 99%

“…New PVOD diagnostic algorithm was proposed recently by Montani et al [5]. The authors introduced subsequent definitions:…”

Section: Recommended Pvod Diagnostic Criteriamentioning

confidence: 99%

See 2 more Smart Citations

Pulmonary Veno-Occlusive Disease: Pathogenesis, Risk Factors, Clinical Features and Diagnostic Algorithm—State of the Art

Szturmowicz¹,

Kacprzak²,

Szołkowska³

et al. 2018

Advances in Respiratory Medicine

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“…The EIF2AK4 gene is currently the only gene identified in heritable PVOD/PCH. Besides the heritable form, environmental risk factors such as occupational organic solvent exposure and chemotherapy have been associated with the development of PVOD/PCH [46][47][48].…”

mentioning

confidence: 99%

Heritable pulmonary hypertension: from bench to bedside

et al. 2017

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Mutations in the BMPR2 gene, and more rarely in ACVRL1, endoglin, caveolin-1, KCNK3 and TBX4 genes predispose to heritable pulmonary arterial hypertension, an autosomal dominant disease with incomplete penetrance. Bi-allelic mutations in the EIF2AK4 gene predispose to heritable pulmonary veno-occlusive disease/pulmonary capillary haemangiomatosis, an autosomal recessive disease with an unknown penetrance.In France, the national pulmonary hypertension referral centre offers genetic counselling and testing to adults and children. Predictive testing is also proposed to adult relatives at risk of carrying a predisposing mutation. In that context, we offer all asymptomatic BMPR2 mutation carriers a programme to detect pulmonary arterial hypertension at an early phase, as recommended by the

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Hemodynamic Response to Treatment and Outcomes in Pulmonary Hypertension Associated With Interstitial Lung Disease Versus Pulmonary Arterial Hypertension in Systemic Sclerosis: Data From a Study Identifying Prognostic Factors in Pulmonary Hypertension Associated With Interstitial Lung Disease

Chauvelot

Gamondès

Berthiller

et al. 2020

Arthritis & Rheumatology

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Objective Patients with systemic sclerosis and both pulmonary hypertension and interstitial lung disease (SSc–PH‐ILD) generally carry a worse prognosis than patients with SSc and pulmonary arterial hypertension (SSc‐PAH) without ILD. There is no evidence of the efficacy of PAH therapies in SSc–PH‐ILD. We undertook this study to compare survival of and response to treatment in patients with SSc–PH‐ILD and those with SSc‐PAH. Methods We analyzed 128 patients (66 with SSc–PH‐ILD and 62 with SSc‐PAH) from 15 centers, in whom PH was diagnosed by right‐sided heart catheterization; they were prospectively included in the PH registry. All patients received PAH‐specific therapy. Computed tomography of the chest was used to confirm or exclude ILD. Results At baseline, patients with SSc–PH‐ILD had less severe hemodynamic impairment than those with SSc‐PAH (pulmonary vascular resistance 5.7 Wood units versus 8.7 Wood units; P = 0.0005) and lower diffusing capacity for carbon monoxide (median 25% [interquartile range (IQR) 18%, 35%] versus 40% [IQR 31%, 51%]; P = 0.0005). Additionally, patients with SSc–PH‐ILD had increased mortality (8.1% at 1 year, 21.2% at 2 years, and 41.5% at 3 years) compared to those with SSc‐PAH (4.1%, 8.7%, and 21.4%, respectively; P = 0.04). Upon treatment with PAH‐targeted therapy, no improvement in the 6‐minute walk distance was observed in either group. Improvement in the World Health Organization functional class was observed less frequently in patients with SSc–ILD‐PH compared to those with SSc‐PAH (13.6% versus 33.3%; P = 0.02). Hemodynamics improved similarly in both groups. Conclusion ILD confers a worse prognosis to SSc‐PH. Response to PAH‐specific therapy is clinically poor in SSc–PH‐ILD but was not found to be hemodynamically different from the response observed in SSc‐PAH.

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Occupational exposure to organic solvents: a risk factor for pulmonary veno-occlusive disease

Cited by 97 publications

References 39 publications

Pulmonary Veno-Occlusive Disease: Pathogenesis, Risk Factors, Clinical Features and Diagnostic Algorithm—State of the Art

Pulmonary Veno-Occlusive Disease: Pathogenesis, Risk Factors, Clinical Features and Diagnostic Algorithm—State of the Art

Heritable pulmonary hypertension: from bench to bedside

Hemodynamic Response to Treatment and Outcomes in Pulmonary Hypertension Associated With Interstitial Lung Disease Versus Pulmonary Arterial Hypertension in Systemic Sclerosis: Data From a Study Identifying Prognostic Factors in Pulmonary Hypertension Associated With Interstitial Lung Disease

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