Comparison of Effects of Treatment of Primary Nocturnal Enuresis With Oxybutynin Plus Desmopressin, Desmopressin Alone or Imipramine Alone: A Randomized Controlled Clinical Trial

Abstract

Combination therapy with desmopressin plus oxybutynin for the treatment of pediatric nocturnal enuresis was well tolerated, and gave significantly faster and more cost-effective results than single drug therapy using either desmopressin or imipramine.

Comparing the efficacy of desmopressin and oxybutynin combination therapy and desmopressin monotherapy in children with primary nocturnal enuresis; a randomized clinical trial

“…In monotherapy group side effects were observed in 23 participants. There was no significant difference between type of treatment and side effects (P = 0.213), which is consistent with Lee and colleagues' study (19).…”

“…However, we did not study the mean bladder adaptation and urine flow pressure in the studied patients. In addition, in a study by Lee and colleagues, the combination therapy with desmopressin plus oxybutynin had a remarkable effect on speed and effectiveness of the treatment on children with nocturnal enuresis (19,20).…”

Efficacy and safety of nasal desmopressin in the long-term treatment of primary nocturnal enuresis

“…"Nonresponse," where the frequency decreased by less than 50% during the first three months following the start of treatment, was observed in six (11%) of the 56 children with PNE, similar to the results [8% (four of the 49 patients)] in Lee's report [5]. The other 50 of the 56 children recruited were enrolled in long-term treatment, because they experienced a >50% reduction in the number of wet nights.…”

“…Medication was interrupted for one week every third month to test for a cure. Urinalysis (osmotic pressure, protein, sugar and occult blood), biochemical (serum alanine aminotransferase, aspartate aminotransferase, creatine kinase, sodium, potassium and creatinine), and hematological (red blood cell, white blood cell and hemoglobin) values were determined every three months for adverse events."Nonresponse," where the frequency decreased by less than 50% during the first three months following the start of treatment, was observed in six (11%) of the 56 children with PNE, similar to the results [8% (four of the 49 patients)] in Lee's report [5]. The other 50 of the 56 children recruited were enrolled in long-term treatment, because they experienced a >50% reduction in the number of wet nights.…”

Laser Acupuncture Treatment in Patients with Monosymptomatic Nocturnal Enuresis

“…Bu nedenlere yönelik çeşitli terapötik yöntemler denenmiştir. Davranış, alarm ve ilaç tedavileri EN tedavi seçeneklerindendir (11)(12)(13)(14)(15)(16). Bunun yanında alternatif tedavi yöntemleri de EN tedavisinde kullanılmaktadır (17).…”