“…This limits the applications for which the DE can be used. For example, some groups (including our team) have recently shown that DOT appears to be capable of accurately diagnosing rheumatoid arthritis (RA) [17, 18, 19] and osteoarthritis (OA) [20, 21, 22] in finger joints. Yet because fingers contain void-like regions, occupy a relatively small volume, and, in the case of RA, may contain inflamed regions that are highly absorbing, the DE is of limited accuracy.…”