2004
DOI: 10.1016/j.clinbiochem.2004.05.027
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Comparison of cytokeratin 20 RNA and angiogenin in voided urine samples as diagnostic tools for bladder carcinoma

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Cited by 19 publications
(7 citation statements)
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“…In our series, the positive results were detected in two patients with urinary tract infections and hematuria. Eissa et al (2004) reported CK20 mRNA was detected in 82.3% of the bladder carcinoma group (97 cases) and in one case of the 34 benign group (2.9%), while the CK-20 test was negative for all of the 46 healthy volunteers, which is concord with our results. Degenerative change or exfoliation of bladder cancer cells can cause release of CK-20 into urine (McKenney et al 2001), which may explains the marked diVerences among malignant, benign and normal groups in our study.…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…In our series, the positive results were detected in two patients with urinary tract infections and hematuria. Eissa et al (2004) reported CK20 mRNA was detected in 82.3% of the bladder carcinoma group (97 cases) and in one case of the 34 benign group (2.9%), while the CK-20 test was negative for all of the 46 healthy volunteers, which is concord with our results. Degenerative change or exfoliation of bladder cancer cells can cause release of CK-20 into urine (McKenney et al 2001), which may explains the marked diVerences among malignant, benign and normal groups in our study.…”
Section: Discussionsupporting
confidence: 92%
“…In our series, no correlations were conWrmed between urinary CK-20 and tumor grade, tumor stage or other clinicopathological factors except age. The same results were reported by Eissa et al (2004). However, Jiang et al (2001) found a positive correlation between urinary CK-20 and nodal status (P < 0.05).…”
Section: Discussionsupporting
confidence: 78%
“…BLAST 9 was used to align the sequences. The genomic sequence of UCA1 was analyzed with a Repbase server 10 specialized for human endogenous retrovirus (HERV) genes and aligned with a consensus genomic sequence of HERV-H (17). Open reading frame (ORF) finder 11 and Artemis software 12 were used to analyze the open reading frame.…”
Section: Methodsmentioning
confidence: 99%
“…Higher levels of Cytokeratin‐20 mRNA are expressed in malignant urothelial tissue compared with normal tissue 11, 12. Urinary CK20 mRNA levels are also raised in transitional cell carcinoma 14–16. There are few reports of immunocytochemistry on urine cytology for detection of urothelial carcinoma 20, 21.…”
Section: Discussionmentioning
confidence: 99%
“…Most cytokeratins are ubiquitous except cytokeratin‐20 (CK20), which is expressed in malignant cells of colon, ovary, and urinary bladder but not in benign urothelium 11–13. Urinary cytokeratin‐20 mRNA levels have the advantage of high sensitivity for all grades of tumor and low rates of positivity in healthy adults 14–16…”
mentioning
confidence: 99%