Comparison of conventional and ultrasound‑guided needle biopsy techniques in the diagnosis of sarcoidosis: a randomized trial

Gnass, Maciej; Szlubowski, Artur; Soja, Jerzy; Kocoń, Piotr; Rudnicka, Lucyna; Ćmiel, Adam; Sładek, Krzysztof; Kużdżał, Jarosław

doi:10.20452/pamw.2828

Cited by 16 publications

(18 citation statements)

References 13 publications

(22 reference statements)

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“…In the study of Szlubowski et al 21 in a group of 41 patients with suspected sarcoidosis, the diagnosis was confirmed in 85.7% of the cases. In the study of Gnass et al 23 (performed with participation of our team), the sensitivity and accuracy of EBUS -FNA were 0.79 and 0.8, respectively, and of EUS -FNA-0.88 and 0.89, respectively. In the study of Szlubowski et al 21 the same technique was used, but a different pathology team assessed cytological smears.…”

Section: Methodsmentioning

confidence: 85%

“…In the study of Szlubowski et al 21 the same technique was used, but a different pathology team assessed cytological smears. In the study of Gnass et al, 23 as in the present study, patients were diagnosed in the same endoscopy unit. The study of Gnass et al 23 , the endoscopic and pathology teams gained more experience in the technique, which resulted in much higher sensitivity of the procedures.…”

Section: Methodsmentioning

confidence: 93%

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The endosonography-guided needle aspiration in the diagnosis of sarcoidosis – randomized study

Kocoń¹,

Szlubowski²,

Kużdżał³

et al. 2017

Polish Archives of Internal Medicine

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Section: Methodsmentioning

confidence: 85%

Section: Methodsmentioning

confidence: 93%

The endosonography-guided needle aspiration in the diagnosis of sarcoidosis – randomized study

Kocoń¹,

Szlubowski²,

Kużdżał³

et al. 2017

Polish Archives of Internal Medicine

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“…Recent investigations have proved a significantly higher sensitivity and accuracy of ultrasound−guided TBNA whether from esophagus or great airways versus conventional one, in the diagnosis of pulmonary sarcoidosis which is manifested with hilar/mediastinal lymphadenopathy. In that way, Annema et al 7 suggest EUS-FNA as the next diagnostic procedure after nondiagnostic bronchoscopy and Gnass et al 8 , on the basis of the results obtained by comparison of conventional and US needle biopsy technics, suggest EUS-FNA as the method of choice for patients with suspicion of sarcoidosis. Ribeiro et al 9 suggest EBUS-TBNA as the first diagnostic line, while Navani et al 10 suggest EBUS-TBNA in combination with the standard, initial bronchoscopic technics (EBB and TBB) as the first line of examination for patients with suspicion of sarcoidosis and intrathoracic lymphadenopathy.…”

Section: Discussionmentioning

confidence: 99%

Тhe value of transbronchial needle aspiration cytology in the diagnosis of stage I and II sarcoidosis

et al. 2017

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Background/Aim. Sarcoidosis is a multisystem infmammatory disease of unknown etiology, with the lungs and intrathoracic lymph nodes the most commonly involved. The aim of this study was to assess the contribution of conventional transbronchial needle aspiration (TBNA) cytology in the diagnosis of sarcoidosis presenting as mediastinal/hilar lymphadenopathy. Methods. In this retrospective study, 58 patients with suspicion of stage I and II sarcoidosis underwent first flexibile, and then, a rigid bronhoscopy, during which TBNA of mediastinal or hilar lumph node with a 19 gauge (G) needle was done. Material from the needle was put on glass slide and prepared for the cytological and histopathological examination. Results. Out of 58 patients submitted to TBNA of mediastinal or hilar lymph nodes, adequate material for cytological diagnostics was obtained in 53 (91.37%). Out of 53 adequate cytological samples, in 38 (71.69%) noncaseous granulomatous inflammation (NGI) was found, while in corresponding histopathological samples, NGI was found in 48 (90.56%), which was significantly higher (p < 0.05). Of cytological smears, out of the cell types typical for granulomatous inflammation, in 26 (63.15%) patients the clusters of the epitheloid cells were found, in 8 (21.05%) there were both, clusters of epitheloid cells and giant multinuclear hystiocytes, and in 6 (15.76%) only single scattered epitheloid cells or small clusters of several epitheloid cells were found. The sensitivity of TBNA cytology in our group of patients with sarcoidosis was 76%, specificity 100% and accuracy 77.34%. Conclusion. TBNA is an efficient and safe procedure in the diagnosis of sarcoidosis, minimally invasive and with a little risk of complications. Using 19 G needle enables obtaining material for histological and cytological analyses, as well which contribute to the sensitivity of diagnosting sarcoidosis. The value of this type of diagnostics depends on qualification and experience both of bronchoscopist and cytologist/pathologist, as well, of the interpreter of such a material.

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“…In stage I/II sarcoidosis, EBUS-TBNA was associated with a sensitivity and accuracy of approximately 80 % [13].…”

Section: Introductionmentioning

confidence: 95%

Endobronchial Ultrasound in Suspected Non-Malignant Mediastinal Lymphadenopathy

et al. 2018

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Comparison of conventional and ultrasound‑guided needle biopsy techniques in the diagnosis of sarcoidosis: a randomized trial

Cited by 16 publications

References 13 publications

The endosonography-guided needle aspiration in the diagnosis of sarcoidosis – randomized study

The endosonography-guided needle aspiration in the diagnosis of sarcoidosis – randomized study

Тhe value of transbronchial needle aspiration cytology in the diagnosis of stage I and II sarcoidosis

Endobronchial Ultrasound in Suspected Non-Malignant Mediastinal Lymphadenopathy

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