Endobronchial Ultrasound in Suspected Non-Malignant Mediastinal Lymphadenopathy

Eickhoff, L.; Golpon, Heiko; Zardo, Patrick; Suhling, Hendrik; Welte, Tobias; Jonigk, Danny; Gottlieb, Jens; Fuehner, Thomas

doi:10.1055/a-0583-0265

Cited by 5 publications

(2 citation statements)

References 49 publications

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“…Lungs contain a dense lymphatic network distributed within the pleura and the parenchyma: the pleural lymphatic network develops within the parietal and the visceral pleura and drains into the lung hilum where it connects with the parenchymal lymphatic supply [90][91][92]. The parenchymal lymphatics pass along the interlobular septa and the bronchoalveolar structures and before connecting with the pleural network and draining into the lobular, interlobular, hilar and mediastinal nodes [93][94][95]. However, the patterns of mediastinal node involvement depend on the site of origin of lung tumour.…”

Section: Metastasis Of Lung Cancermentioning

confidence: 99%

Mediastinal tumours and pseudo-tumours: a comprehensive review with emphasis on multidisciplinary approach

Ghigna

Montpréville

2021

Eur Respir Rev

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The diagnosis of a mediastinal mass may be challenging for clinicians, since lesions arising within the mediastinum include a variety of disease entities, frequently requiring a multidisciplinary approach. Age and sex represent important information, which need to be integrated with imaging and laboratory findings. In addition, the location of the mediastinal lesion is fundamental; indeed, we propose to illustrate mediastinal diseases based on the compartment of origin. We consider that this structured approach may serve as hint to the diagnostic modalities and management of mediastinal diseases. In this review, we present primary mediastinal tumours in the evolving context of new diagnostic and therapeutic tools, with recently described entities, based on our own experience with >900 cases encountered in the past 10 years.

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Section: Metastasis Of Lung Cancermentioning

confidence: 99%

Mediastinal tumours and pseudo-tumours: a comprehensive review with emphasis on multidisciplinary approach

Ghigna

Montpréville

2021

Eur Respir Rev

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“…This can also lead to delays in the initiation of treatment. For this reason, the diagnostic value of mediastinoscopy increases further, especially in non-cancer, mediastinal pathologies (6,18). This study has some limitations.…”

Section: Discussionmentioning

confidence: 91%

The risk of tuberculosis bacilli seeding during mediastinoscopy in mediastinal tuberculosis: Is it clinically important?

BÜYÜKKARABACAK¹,

PİRZİRENLİ²,

Gürz³

et al. 2022

JECM

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Mediastinoscopy is the gold standard for diagnosis in the absence of parenchymal lesions in mediastinal tuberculosis lymphadenitis. During mediastinoscopy biopsy, tuberculous bacillus seeding into the mediastinum is a rare complication. This study aimed to test the safety of mediastinoscopy in terms of Mycobacterium tuberculosis seeding in the mediastinum by microbiologically evaluating mediastinal lavage samples taken before and after biopsy. Classical cervical mediastinoscopy was performed all of patients and who were reported as granulomatous inflammatory events results of histopathological examinations and who underwent mediastinal lavage before and after biopsy, were included in the study. All the lavage fluids were tested for AFB and subjected to Mycobacterium tuberculosis PCR DNA testing and standard tuberculosis culture. The patients were divided into two groups, Group 1: Necrotizing granulomatous inflammation, Group 2: non-necrotizing granulomatous inflammation. The microbiological tests of the patients in Group 1 were negative before biopsy. However, in two patients of Group 1, the results of cultures of lavage fluids that taken from after biopsy were positive for tuberculosis. In all patients in Group 2, all microbiological tests of the lavage fluids were negative (Power of the decision: 99.8%, with 5% error). All of patients in group 1, Antituberculosis treatment was initiated and continued for 6 months. There weren’t seen any serius complications due to treatment and recurrence during the follow-up period. Mediastinoscopy can be used safely, with low morbidity and mortality rates and a high success rate for the diagnosis of mediastinal tuberculosis.

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Endobronchial Ultrasound‐Guided Transbronchial Needle Aspiration

Fielding¹

2020

Endobronchial Ultrasonography

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Endobronchial Ultrasound in Suspected Non-Malignant Mediastinal Lymphadenopathy

Abstract: EBUS-TBNA revealed a specific cause for suspected non-malignant lymphadenopathy in one-third of cases and was associated with excellent specificity. Predominant specific causes were granuloma, besides from tumor. In 3 patients pathogen could be isolated by TBNA.

Cited by 5 publications

References 49 publications

Mediastinal tumours and pseudo-tumours: a comprehensive review with emphasis on multidisciplinary approach

Mediastinal tumours and pseudo-tumours: a comprehensive review with emphasis on multidisciplinary approach

The risk of tuberculosis bacilli seeding during mediastinoscopy in mediastinal tuberculosis: Is it clinically important?

Endobronchial Ultrasound‐Guided Transbronchial Needle Aspiration

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