Comparison of Clonidine with Dexmedetomidine as an Adjuvant to Local Anesthetic Agent in Supraclavicular Brachial Plexus Block

Sharma, Aparna; Sharma, Abhishek; Sharma, Anupam; Sood, Anil K.; Sharma, Girish; Thakur, Abhishake

doi:10.21088/ijaa.2349.8471.6619.2

Cited by 2 publications

(3 citation statements)

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“…1 ). 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 Among 24 included studies, 21 were double-blind and 2 were open-label. One study did not specify the type of blinding.…”

Section: Resultsmentioning

confidence: 99%

Dexmedetomidine versus clonidine as an adjuvant to local anaesthetic in brachial plexus blocks: a meta-analysis of randomised controlled trials

Bajpai

Patel²,

Dwivedi³

et al. 2023

Brazilian Journal of Anesthesiology (English Edition)

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Section: Resultsmentioning

confidence: 99%

Dexmedetomidine versus clonidine as an adjuvant to local anaesthetic in brachial plexus blocks: a meta-analysis of randomised controlled trials

Bajpai

Patel²,

Dwivedi³

et al. 2023

Brazilian Journal of Anesthesiology (English Edition)

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“…α2-AM in analgesic doses is known to cause muscle relaxation [37]. This effect is associated with inhibition of α2-AR at the level of the spinal cord interneurons [12]. It should be noted that tizanidine is effective in reducing muscle spasticity in stroke, traumatic brain injury and multiple sclerosis due to the pronounced muscle relaxant effect [9].…”

Section: Muscle Relaxationmentioning

confidence: 99%

“…It was shown that stimulation of central α1-receptors reduces the hypnotic effect of α2-AM, for example, dexmedetomidine [11]. It was shown that with the introduction of α2-AM in high and toxic doses at the initial period of drug action, the effects of α1-AR activation prevail [12].…”

Section: Introductionmentioning

confidence: 99%

Tendencies and perspectives of central alpha2-adrenomimetic application in medicobiological research

et al. 2019

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The pharmacodynamic effects of the administration of 2-adrenergic agonists both in a monovariant and in combination with drugs of other pharmacological groups are considered. Based on analysis of safety nonclinical studies the characteristics of main physiological effects of 2-adrenergic receptors as well as physiological effects of 2-agonists on various organs and systems are presented. For the determination of tendencies and directions in research of central 2-AM (dexmedetomidine) the analysis of bibliographical data, accumulated and extracted from Medline database with 5 year time-filter (VOSviewer, 1.6.11 version) has been carried out. For the further research of central 2-adrenomimetics and their application in clinical practice the following perspective directions have been determined: the study of effects and mechanisms of cytoprotectant and antioxidant action, the study of the use of drugs in a monovariant and in combinations for the development of analgesic drugs, anesthesia and development of combined formulations with a delayed release of antagonists designed to mitigate side effects.

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Comparison of Clonidine with Dexmedetomidine as an Adjuvant to Local Anesthetic Agent in Supraclavicular Brachial Plexus Block

Cited by 2 publications

References 0 publications

Dexmedetomidine versus clonidine as an adjuvant to local anaesthetic in brachial plexus blocks: a meta-analysis of randomised controlled trials

Dexmedetomidine versus clonidine as an adjuvant to local anaesthetic in brachial plexus blocks: a meta-analysis of randomised controlled trials

Tendencies and perspectives of central alpha2-adrenomimetic application in medicobiological research

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