Information about the presence of drugs and their metabolites in the water of centralized drinking water supply systems is presented; the main groups of drugs found in purified drinking water of large cities are given. The main groups of drugs found in a centralized drinking water supply system include antidepressants (amitriptyllin), antibacterial drugs of various groups (amoxicillin, ciprofloxacin, tetracycline, azithromycin), narcotic analgesics (cocaine, morphine, their derivatives), psychoactive stimulants, benzodiazepines, hormones (estrogen and its metabolites estrone and estriol). A high level of potential risk to public health is marked due to the presence of steroid hormones and their active metabolites in drinking water. The concept of endocrine dysregulating complexes is formulated. Such complexes can be of a different nature of origin, but all of them affect receptors for estrogen and progesterone. It leads to abnormalities of hormonal regulation, affects endogenous synthesis, transport and secretory function. From the standpoint of ecotoxicology, further ways of working out the problem of the presence of steroid hormones in drinking water are proposed: the development of theoretical approaches to substantiating hygienic standards concerning the monitoring of these compounds in the water of centralized drinking water supply systems.
The research objective was a morphological analysis of posttraumatic regeneration of musculoskeletal tissue in rats after experimental blast injury with field simulation of remote musculocutaneous injury of lower limbs. Wound process was evaluated visually and by histological characteristics of injury zones. This research helped to deepen understanding of details of regenerative process of blast musculocutaneous injury and formation of regenerating muscular and connective tissue of skeletal muscle in rats
Search for new ligands selective to various 5HT2 receptor subtypes is an important scientific and practical problem for experimental psychopharmacology and clinical medicine. Most of existing antagonists of the 5HT2A- and 5HT2C- subtypes have necessary anti-anxiety and antipsychotic properties, but they are partially selective to 5HT2B receptors. The activation of the latter ones leads to cardiotoxic side effects, so it significantly limits clinical use of these drugs. For the search of new highly selective ligands of 5HT2A/C receptors an in silico screening algorithm was proposed using PScore.Max and Affinity.maxPScore indices, taking into account the affinity of low molecular weight compounds to each of 5HT2 receptor subtype. Cyclic physiologically active substances of peptide nature have been proposed as new promising drugs with antipsychotic activity. Based on the CXXC library, a number of cyclopeptides with a high selectivity of the structure to the target binding sites were selected for further in vitro studies by extending the peptide chain.It was also found that a promising direction for increasing the selectivity of peptide ligands to 5HT2A/C receptors is the introduction of non-proteinogenic amino acids during the formation of a starting docking library. Their choice will be stipulated by the nature of interactions between the reference ligands and amino acid residues of the binding site.
The study aims to compare the methods of Mucosat drug use and administration for achieving the desired therapeutic effect in the treatment of osteoarthritis. Despite extensive evidence base, improving complex therapy schemes for the use of successive and complementary dosage forms with the appropriate drug administration and use in order to achieve the desired therapeutic effect is still a valid aim. In the course of the study, 50 knee osteoarthritis patients were examined and treated during the period from November, 2019 to April, 2020. A clinical trial was carried out to assess Mucosat oral and parental administration effectiveness in the patients comparing their physical activity, functional ability and quality of life. The number of undesired side effects identified the degree of therapeutic tolerance against the comorbid diseases identified. A comparison of the therapeutic efficacy and tolerability of Musocat intramuscular and capsule administration, patient compliance, the need to take non-steroidal anti-inflammatory drugs (NSAIDs) was drawn. Statistica 12 and Excel 2016 were used to carry out the statistical analysis of the data obtained. The study was generally marked by diagnostic accuracy with the use of modern methods, group homogeneity, prospective observational design. By the time of pharmacotherapy completion, physical activity has become optimal in the study groups. However, parental therapy had significantly higher effectiveness than the oral one on all the subscales. As a result, articular syndrome severity has been reduced and the functional state of the joints expanded. The study has shown that Mucosat demonstrates high efficacy both in injectable solution and capsule dosage forms as a basic chondroprotective drug. Mucosat pharmacotherapy course has contributed to permanent discontinuation of NSAIDs before completion of the therapy. The superiority of Mucosat parenteral administration over the oral one has been proven.
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