Morphological Characteristics of Posttraumatic Skeletal Muscle Regeneration After Experimental Blast Injury

Цель. Создание доступной модели минно-взрывной травмы различной степени тяжести у крыс. Материалы и методы. Взрывное повреждение мягких тканей бедра крыс моделировали с помощью строительно-монтажного пистолета (СМП) и специально разработанной стойки, которая обеспечивала фиксацию СМП во время выстрела. Для имитации повреждения от поражающих элементов в стволе СМП размещали стальные осколки. Результаты. Макроскопическая оценка повреждений показала, что они имеют признаки, характерные для поражения мягких тканей ударной волной, струей пламени, поражающими элементами. Показана возможность варьировать степень поражения тканей за счет мощности порохового заряда, отсутствия или наличия поражающих элементов. Выводы. Предложенная модель воспроизводит минно-взрывную травму и может быть использована в любой научно-исследовательской лаборатории, занимающейся вопросами экспериментальной медицины.

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Modeling the Skeletal Muscle Injury in Rats

Kholodnyi

2022

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Muscles are the most important executive organs - effectors. Both according to morphological and functional characteristics, muscles are divided into two types - striated and smooth. Striated muscles, in turn, are usually divided into skeletal and cardiac. Striated muscles form the motor apparatus of the skeleton, oculomotor, chewing and other motor systems in animals. The striated muscles, with the exception of the heart muscle, are completely controlled by the central nervous system, they are devoid of automatism.The problem of damage to skeletal muscles is very relevant and widespread. These injuries disrupt the musculoskeletal function of animals, up to its complete loss. To search for methods for restoring the structure and function of muscles, experiments are being carried out on laboratory animals. This article is devoted to the selection of the optimal model of skeletal muscle injury, performed on laboratory rats. The study was conducted on Wistar rats. The choice of the muscle on which the models will be worked out, as well as the surgical access to it, is substantiated. Three options for inflicting damage to muscle tissue (cut wounds directed parallel to muscle fibers; cut wounds directed across muscle fibers; crushed wounds of muscle tissue) and the timing of healing of these injuries are proposed. The result of the study showed that the gastrocnemius muscle is the most suitable for modeling damage to muscle tissue in rats, and a crushed wound has the longest healing time.

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Morphological Characteristics of Posttraumatic Skeletal Muscle Regeneration After Experimental Blast Injury

Cited by 3 publications

References 2 publications

Histomorphometric Analysis of Different Phases of Skeletal Muscle Regeneration after Mechanical Injury

Histomorphometric Analysis of Different Phases of Skeletal Muscle Regeneration after Mechanical Injury

Модель Минно-Взрывной Травмы

Modeling the Skeletal Muscle Injury in Rats

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