Comparison of clinical characteristics between SARS-CoV-2 Omicron variant and Delta variant infections in China

Li, Qinggang; Liu, Xiaorui; Li, Lei; Hu, Xiaobo; Cui, Guangying; Sun, Ranran; Zhang, Donghua; Li, Juan; Li, Yonghong; Zhang, Yong; Shen, Shen; He, Ping; Li, Shasha; Liu, Yanmin; Yu, Zujiang; Ren, Zhigang

doi:10.3389/fmed.2022.944909

Cited by 14 publications

(15 citation statements)

References 26 publications

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“…Among the patients admitted to ICU, 73% had hypertension and 49% diabetes in Delta, while 69% had hypertension and 62% diabetes in Omicron wave. There have been studies showing a comparison of clinical characteristics between the Delta variant and the Omicron variant of SARS-COV-2 infections [13] however not much research has been done comparing the CBC parameters and emphasizing its relevance.…”

Section: Discussionmentioning

confidence: 99%

Retrospective Observational Study of Complete Blood Count (CBC) Parameters and ICU Mortality of COVID-19 Disease in Delta Variant and Omicron Variant in a Community-Based Hospital in New York City

Yadav¹,

Yadav²,

Pokhriyal³

et al. 2023

Cureus

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Background: Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) is the official name of COVID-19, a respiratory infection that had the first case reported from the Hubei province of China on December 8, 2019. This virus is the main etiological agent behind the most dreaded pandemic of pneumonia that has spread to the entire world in a brief period and continues to pose a threat. The first wave corresponded with the period from February 2020 to June 2020, the Delta variant occurred around the middle of June 2021 and the Omicron wave was reported from December 2021 to February 2022.Objective: This study aims to compare the Delta and the Omicron variants of COVID-19 infection in a community-based hospital in New York City considering the comparison of ICU admissions in both variants. We aim to study the comparison of complete blood count (CBC) parameters and inflammatory markers of patients admitted to ICU stratified by two waves of COVID-19 infection. We aim to analyze the association of CBC parameters at admission and the discharge during ICU stay in both variants. We also aim to study the association of CBC parameters at admission and discharge with ICU mortality in both variants.Methods: We conducted a retrospective observational study based on data from randomly selected hospitalized patients with COVID-19 in a community-based hospital in New York City during the Delta variant and the Omicron wave. A total of 211 patients COVID-19 positive from June to July 2021 (Delta variant) and 148 patients from December to February 2022 (Omicron wave) were included in the study. A comparison was done between the basic characteristics of patients with and without ICU admissions in both variants of COVID-19. We compared the relationship of different parameters of CBC (hemoglobin (Hgb), white blood count (WBC), lymphocytes, neutrophils, and platelets) on ICU admission and further analyzed any changes associated with ICU mortality. Logistic regression was performed to evaluate the relationship of different presenting CBCs on patients' disposition to ICU.Result: A total of 211 patients (106 female) in the Delta wave (2021 variant) and 148 patients (80 female) in the Omicron wave (2022 variant) with an average ages of 60.9 ±18.10 (Delta variant) and 63.2 ± 19.10 (Omicron variant) were included in this study. There were 45 patients (21.3%) in the Delta wave and 42 patients (28.4%) in the Omicron wave were admitted to ICU. The average length of hospital stay was seven days in the Delta wave and nine days in the Omicron wave. No significant association was found between presenting cell count and ICU admission (p>0.05). Significant associations were found between different cell counts on admission and discharge and death in Delta waves except Hgb and platelets on admission. However, in the Omicron variant, a significant association was found only between WBC on admission and discharge, and Hgb and neutrophil on discharge with death in the univariate model. Conclusion:Comparative study of different clinical parameters betwee...

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Section: Discussionmentioning

confidence: 99%

Retrospective Observational Study of Complete Blood Count (CBC) Parameters and ICU Mortality of COVID-19 Disease in Delta Variant and Omicron Variant in a Community-Based Hospital in New York City

Yadav¹,

Yadav²,

Pokhriyal³

et al. 2023

Cureus

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“…2). Twenty-two studies were from populations primarily of European ancestry [8,32,[40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59], eight studies on East Asians [60][61][62][63][64][65][66][67], three studies on South Asians [68][69][70], three studies on Latinos [71][72][73], four studies on populations in Africa [74][75][76][77], and one study from West Asia (Turkey [78]). The location of studies, with the prevalence indicated by the color intensity, and the cohort size indicated by the size of the circles, shows that Western countries report the highest prevalence, while studies from East Asia and Africa report the lowest prevalence (Fig.…”

Section: Properties Of Studiesmentioning

confidence: 99%

“…2). Twenty-five studies were from populations primarily of European ancestry [9,30,, seventeen studies on East Asians [61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77] (note that one of these studies, [75], reports on the same cohort as [74], and therefore was removed from the meta-analysis), eight studies on South Asians [79][80][81][82][83][84][85][86], four studies on Latinos/Hispanics [87][88][89][90], five studies on populations in Africa [91][92][93][94][95], and three studies from the Middle East [96][97][98]. The location of studies, with the prevalence indicated by the color intensity, and the cohort size indicated by the size of the circles, shows that Western countries report the highest prevalence, while studies from East Asia and the Middle East report the lowest prevalence (Fig.…”

Section: Properties Of Studiesmentioning

confidence: 99%

Prevalence of Olfactory Dysfunction with the Omicron Variant of SARS-CoV-2: A Systematic Review and Meta-analysis

Bartheld

Wang

2022

Preprint

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The omicron variant is thought to cause less olfactory dysfunction than previous variants of SARS-CoV-2, but the reported prevalence differs greatly between populations and studies. Our systematic review and meta-analysis provide information about regional differences in prevalence as well as an estimate of the global prevalence of olfactory dysfunction based on 41 studies reporting on nearly 600,000 patients infected with the omicron variant. Our estimate of the omicron-induced prevalence of olfactory dysfunction in populations of European ancestry is 11.6%, while it is significantly lower in all other populations, at 2.9-5.4%. When ethnic differences and population sizes are taken into account, the global prevalence of omicron-induced hyposmia in adults is estimated at 5.2%. Omicron's effect on olfaction is 3-4fold lower than that of the alpha or delta variant, according to previous meta-analyses and our analysis of studies that directly compared prevalence of olfactory dysfunction between omicron and previous variants. The profile of prevalence differences between ethnicities mirrors the results of a recent genome-wide association study that implicated a gene locus encoding an odorant-metabolizing enzyme, UDP glycosyltransferase, to be linked to the extent of COVID-related loss of smell. Our analysis is consistent with the hypothesis that this enzyme contributes to the observed population differences.

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“…In China, the prevalence of olfactory dysfunction caused by the Omicron variant is 0-9% (Li et al 2022;Liang et al 2022;Yang et al 2022;Zhang et al 2022;. However, the sample size is relatively small and the researchers focus on the characteristics and clinical symptoms with insufficient discussion on chemosensory changes.…”

Section: Introductionmentioning

confidence: 99%

“…In China, the prevalence of olfactory dysfunction caused by the Omicron variant is 0-9% (Li et al 2022; Liang et al 2022; Yang et al 2022; Zhang et al 2022; Shen et al 2022). However, the sample size is relatively small and the researchers focus on the characteristics and clinical symptoms with insufficient discussion on chemosensory changes.…”

Section: Introductionmentioning

confidence: 99%

Smell, taste and chemesthesis disorders in patients with the SARS-CoV-2 Omicron variant in China

Chen

Liu

et al. 2023

Preprint

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Many studies have confirmed that chemosensory disorder (including smell, taste and chemesthesis) is one of the symptoms of COVID-19 infection. However, new data indicated that the changes of chemosensory sensation caused by COVID-19 may be different among different populations and COVID-19 variants. At present, there are few studies focusing on the influence of Omicron on qualitative changes and quantitative reductions of chemosensory in China. We conducted a cross‑sectional study on COVID-19 Omicron variant patients to investigate the prevalence of chemosensory disorders and their chemosensory function before and during infection by online questionnaire. A total of 1245 patients with COVID-19 completed the study. The prevalence of smell, taste and chemesthesis disorder was 69.2%, 67.7% and 31.4% respectively. Sex, age, smoking and COVID-19-related symptoms such as lack of appetite, dyspnea and fatigue may have association with chemosensory disorders during COVID-19. Self-ratings of chemosensory function revealed that patients experienced a decline in the function of smell, taste and chemesthesis generally. Further studies are needed to combine the data using objective assessment and investigate the factors affecting chemosensory in COVID-19 through longitudinal research.

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Comparison of clinical characteristics between SARS-CoV-2 Omicron variant and Delta variant infections in China

Cited by 14 publications

References 26 publications

Retrospective Observational Study of Complete Blood Count (CBC) Parameters and ICU Mortality of COVID-19 Disease in Delta Variant and Omicron Variant in a Community-Based Hospital in New York City

Retrospective Observational Study of Complete Blood Count (CBC) Parameters and ICU Mortality of COVID-19 Disease in Delta Variant and Omicron Variant in a Community-Based Hospital in New York City

Prevalence of Olfactory Dysfunction with the Omicron Variant of SARS-CoV-2: A Systematic Review and Meta-analysis

Smell, taste and chemesthesis disorders in patients with the SARS-CoV-2 Omicron variant in China

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