Comparison of Clinical and Biomechanical Outcomes between Partial Fibulectomy and Drug Conservative Treatment for Medial Knee Osteoarthritis

Abstract

Background Upper partial fibulectomy has been preliminarily proved to have the efficacy for pain alleviation and improvement of function in patients with mild to moderate medial compartment knee osteoarthritis (KOA). However, the previous studies lack the control group with other treatments. The aim of this prospective, randomized controlled study is to compare the clinical and biomechanical effects between upper partial fibulectomy and drug conservative treatment on improvement of clinical pain, function, and gait for patients with mild to moderate medial knee osteoarthritis (KOA) and further discuss its biomechanical mechanism. Methods From August 2016 to February 2017, 49 and 48 patients with mild to moderate medial KOA were allocated to fibulectomy and drug groups. We assessed the patients' visual analog scale (VAS) pain score, Hospital for Special Surgery (HSS) knee score, limb alignment, passive flexion/extension range of motion (ROM) of the knee, and 3D gait kinematics and kinetics parameters before and after intervention. Repeated-measures ANOVA with Dunnett's post hoc assessment and multivariate analysis of variance were applied for intragroup and intergroup comparisons, respectively. Results The improvement in the fibulectomy group on the VAS pain score, HSS knee score, walking speed, and walking knee range of motion (ROM) was statistically better than that in the drug group. The decreased overall peak knee adduction moment (KAM) (decreased by 16.1%) and hip-knee-ankle (HKA) angle (decreased by 0.99° from a more varus alignment to a more neutral alignment) of the affected and operated side 1 year after surgery were observed in the fibulectomy group. Conclusion This research demonstrated that as a biomechanical intervention, upper partial fibulectomy can be a better choice in pain relief and function and gait improvement than drug conservative treatment for patients with early-stage knee OA. The long-term clinical outcomes, indication, and rationale for the improvement in clinical symptoms should be investigated further.

How effective is proximal fibular osteotomy in redistributing joint pressures? Insights from an HTO comparative in-silico study

“…Pressure reduction in the medial compartment may result in an immediate reduction in pain, as reported in some clinical studies [12,26,70,71] and supporting recent studies findings such as [13,22,72]. Based on the few published studies, PFO promises to be safe (i.e.…”

Unicompartmental knee arthroplasty is superior to high tibial osteotomy for the treatment of medial unicompartmental osteoarthritis: A systematic review and meta-analysis

“…[2,3] For mild medial unicompartmental knee OA (Kellgren-Lawrence grade [K-L grade] I), conservative therapy, including functional training, physical therapy, intra-articular injection, and oral medicines, can relieve pain and improve quality of life. [4] However, for more serious medial unicompartmental knee OA (K-L grade II-IV), operations may obtain more ideal results. [5,6] High tibial osteotomy (HTO) and unicompartmental knee arthroplasty (UKA) are widely used in the treatment of medial unicompartmental knee OA.…”

Strontium ion attenuates osteoarthritis through inhibiting senescence and enhancing autophagy in fibroblast-like synoviocytes

“…Many treatments have been applied to OA [3,4]. Early-stage OA is mainly treated conservatively with oral medication or drug injection into the joint cavity to reduce joint damage, but the outcome is often unsatisfactory [5]. Most OA patients eventually need surgery [6], which seriously affects the patient's quality of life and imposes a signi cant economic burden as well.…”