More than 100 surgical procedures have been reported to address recurrent patellar instability. Trochlear dysplasia is the most common finding among the anatomic risk factors for recurrent patellar instability. Various studies have shown that trochleoplasty combined with medial patellofemoral ligament reconstruction is an effective technique to treat recurrent patellar instability. Nevertheless, trochleoplasty is still a daunting procedure for surgeons because of its multiple and gloomy complications. This article introduces a technique to treat recurrent patellar instability with severe trochlear dysplasia: precise arthroscopic mini-trochleoplasty (PAM trochleoplasty) combined with medial patellofemoral ligament reconstruction. This technique precisely removes the supratrochlear spur and trochlear bump, accurately reshapes the trochlear sulcus with minimal invasion and less osteotomy volume, and keeps the sulcus cartilage intact. The purpose of this technique is to develop trochleoplasty into a common and safe technique, which has good outcomes and low complications.
Steam on the camera may happen in any arthroscopic procedure, especially in shoulder arthroscopy. Although multiple techniques and devices have been applied to avoid steam, it still cannot be prevented completely. We designed a simple device to terminate this problem by protecting against the ingress of water.
Osteoarthritis (OA) mainly occurs in the elderly population and seriously affects their quality of life. The strontium (Sr) ion has shown positive effects on the bone tissue and promises on OA treatment. However, the adequate treatment dosage and the underlying mechanisms are unclear. This study investigated the effect of different concentrations of Sr ion on a mouse model of OA induced by destabilization of the medial meniscus (DMM) surgery, as well as the underlying mechanisms. DMM-induced OA mice were received intra-articular injection different concentration Sr ion, and found a suitable concentration of Sr ion to improve OA. Furthermore, the mechanism by which Sr ion mediated senescence and autophagy of broblast-like synoviocytes (FLSs) in Synovial tissues of DMM-induced OA mice were investigated. In OA mice treated with 10 µl contained 5 mmol/L SrCl 2 showed the best effect on improved the pain-related behaviors and cartilage damage. In addition, in vivo and vitro experiments revealed that Sr ion inhibits senescence and improves autophagy function of FLSs. We also found that enhancement of autophagy function of FLSs can effectively slow down itself senescence. Therefore, we show that Sr ions through AMPK/mTOR/LC3B-signal axis improves FLSs autophagy function and delays FLSs senescence, furthermore, improve OA. These results suggest that senescence and autophagy function of FLSs may serve as promising targets for OA treatment and Sr ion may inhibit OA progression through these two targets.
Osteoarthritis (OA) mainly occurs in the elderly population and seriously affects their quality of life. The strontium (Sr) ion has shown positive effects on the bone tissue and promises on OA treatment. However, the adequate treatment dosage and the underlying mechanisms are unclear. This study investigated the effect of different concentrations of Sr ion on a mouse model of OA induced by destabilization of the medial meniscus (DMM) surgery, as well as the underlying mechanisms. DMM-induced OA mice were received intra-articular injection different concentration Sr ion, and found a suitable concentration of Sr ion to improve OA. Furthermore, the mechanism by which Sr ion mediated senescence and autophagy of fibroblast-like synoviocytes (FLSs) in Synovial tissues of DMM-induced OA mice were investigated. In OA mice treated with 10 µl contained 5 mmol/L SrCl2 showed the best effect on improved the pain-related behaviors and cartilage damage. In addition, in vivo and vitro experiments revealed that Sr ion inhibits senescence and improves autophagy function of FLSs. We also found that enhancement of autophagy function of FLSs can effectively slow down itself senescence. Therefore, we show that Sr ions through AMPK/mTOR/LC3B-Ⅱ signal axis improves FLSs autophagy function and delays FLSs senescence, furthermore, improve OA. These results suggest that senescence and autophagy function of FLSs may serve as promising targets for OA treatment and Sr ion may inhibit OA progression through these two targets.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.