Comparison of CCD-equipped laser speckle flowgraphy with hydrogen gas clearance method in the measurement of optic nerve head microcirculation in rabbits

Takahashi, Hiroaki; Sugiyama, Tetsuya; Tokushige, Hideki; Maeno, Takatoshi; Nakazawa, Toru; Ikeda, Tsunehiko; Araie, Makoto

doi:10.1016/j.exer.2012.12.003

Cited by 99 publications

(86 citation statements)

References 27 publications

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“…The methodologies used to obtain ocular blood flow measurements can involve both invasive and noninvasive techniques. For example, the dye dilution method 6 is an invasive technique, while color Doppler imaging, 7 laser Doppler velocimetry, 8 laser speckle flowgraphy (LSFG) (LSFG-Navi, Softcare, Fukuoka, Japan), [9][10][11][12][13][14][15][16] and the retinal functional imager methodologies 17 are considered to be noninvasive techniques. The LSFG device has been used to visualize blood flow distributions in the ocular fundus.…”

Section: Central Retinal Vein Occlusion (Crvo) Is An Ophthalmologic Vmentioning

confidence: 99%

Retinal Blood Flow Correlates to Aqueous Vascular Endothelial Growth Factor in Central Retinal Vein Occlusion

Yamada

Suzuma

Matsumoto

et al. 2015

Retina

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Results: Fluorescein angiography found 20 ischemic and 25 non-ischemic type eyes. Aqueous VEGF concentration in the ischemic type was significantly higher than that in the non-ischemic type (P = 0.01). Arteriovenous passage time was significantly correlated to the logarithm of the aqueous VEGF concentration (P = 0.0001). MBR of the affected eye / MBR of the unaffected eye of the ischemic type was significantly lower than the non-ischemic type (P = 0.039). Additionally, MBR was significantly correlated both to the logarithm of the aqueous VEGF concentration (P < 0.0001) and to the arteriovenous passage time (P = 0.0001).

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Section: Central Retinal Vein Occlusion (Crvo) Is An Ophthalmologic Vmentioning

confidence: 99%

Retinal Blood Flow Correlates to Aqueous Vascular Endothelial Growth Factor in Central Retinal Vein Occlusion

Yamada

Suzuma

Matsumoto

et al. 2015

Retina

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“…In addition, our recent studies suggested that absolute MBR values for the ONH correlated with CBF, indicating the quantifiability of these values in the absence of large topographical and color differences in the ONH [31,33] . This condition was probably observed in the present study because we compared MBR values among eyes with myopic ONHs, which have similar topographical and color appearances.…”

Section: Discussionmentioning

confidence: 99%

“…We used LSFG for assessment of ONH blood flow in the current study because its validity and reproducibility have been previously demonstrated [31,32] . In addition, our recent studies suggested that absolute MBR values for the ONH correlated with CBF, indicating the quantifiability of these values in the absence of large topographical and color differences in the ONH [31,33] .…”

Section: Discussionmentioning

confidence: 99%

“…The mean blur rate (MBR) represents the blurring of the speckle pattern formed by the interference of a laser scattered by blood cells moving in the ocular fundus. A previous study suggested that absolute MBR values for the ONH correlate with capillary blood flow (CBF) and linearly change with it, indicating the quantifiability of these values at least under certain conditions, i.e., in the absence of large topographical or color differences in the ONH induced by races, diseases, etc., which affect absorption and reflection of the laser beam [31] . LSFG measurements were conducted a month after the withdrawal of all anti-glaucoma eyedrops in patients who were using them.…”

Section: Assessment Of Onh Blood Flowmentioning

confidence: 99%

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Clinical Usefulness of the Measurement of Optic Nerve Head Blood Flow in Myopic Normal-Tension Glaucoma

Sugiyama¹,

Nakamura²,

Shimizu³

et al. 2015

International Journal of Ophthalmic Research

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“…1), a noninvasive quantitative method for determining ocular blood flow [14, 15], is based on the changes in the speckle pattern of laser light reflected from the fundus of the eye [16, 17]. LSFG is dependent on the movement of erythrocytes in the retina, the choroid, and the optic nerve head (ONH), and the mean blur rate (MBR) is an indicator of ocular blood ﬂow [18, 19]. Changes in the MBR have various pulse wave patterns that are synchronized with the cardiac cycle.…”

Section: Introductionmentioning

confidence: 99%

Pulse Waveform Analysis in Ocular Microcirculation by Laser Speckle Flowgraphy in Patients with Left Ventricular Systolic and Diastolic Dysfunction

et al. 2018

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Purpose: To determine: (1) whether variables of a pulse wave form analysis of ocular microcirculation shown by laser speckle flowgraphy (LSFG) correlate with left ventricular (LV) systolic dysfunction and (2) whether these variables correlate with LV diastolic dysfunction in subjects without LV systolic dysfunction as assessed by echocardiography. Methods: We studied 200 consecutive subjects. LV systolic dysfunction has been determined to be present when the LV ejection fraction was < 50%. LV diastolic dysfunction was diagnosed when subjects had an E/e’ ratio ≥15 and an e’ velocity < 10 cm/s. We evaluated the pulse waveform analysis variables “rising rate” and the blowout score (BOS) using LSFG in the optic nerve head (ONH) and choroid. Results: The brain natriuretic peptide (BNP) level, the rising rate in the choroid area (rising rate-choroid), and heart rate were revealed as independent factors for LV systolic dysfunction, and BOS-choroid was identified as an independent factor for LV diastolic dysfunction. The areas under the curve (AUC) of BNP and rising rate-choroid for LV systolic dysfunction were 0.83 and 0.81, respectively. The AUC of BOS-choroid for LV diastolic dysfunction was 0.73. Conclusion: Pulse waveform analysis in the choroid has a significant correlation with LV systolic and LV diastolic function.

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Comparison of CCD-equipped laser speckle flowgraphy with hydrogen gas clearance method in the measurement of optic nerve head microcirculation in rabbits

Cited by 99 publications

References 27 publications

Retinal Blood Flow Correlates to Aqueous Vascular Endothelial Growth Factor in Central Retinal Vein Occlusion

Retinal Blood Flow Correlates to Aqueous Vascular Endothelial Growth Factor in Central Retinal Vein Occlusion

Clinical Usefulness of the Measurement of Optic Nerve Head Blood Flow in Myopic Normal-Tension Glaucoma

Pulse Waveform Analysis in Ocular Microcirculation by Laser Speckle Flowgraphy in Patients with Left Ventricular Systolic and Diastolic Dysfunction

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