“…Consequently, several clinical studies that examined betweensubject comparisons of MBR in human ONH have been published. [23][24][25] However, LSFG measurements are affected by laser speckle signal bias due to the influence of various factors including retinal pigment epithelial scattering, laser beam reflectance, thickness of the vascular wall, and target tissue absorption. Therefore, interpretation of MBR comparison between different subjects, different eyes, or even different retinal locations must be done with caution.…”