Retinal Blood Flow Correlates to Aqueous Vascular Endothelial Growth Factor in Central Retinal Vein Occlusion

Abstract

Results: Fluorescein angiography found 20 ischemic and 25 non-ischemic type eyes. Aqueous VEGF concentration in the ischemic type was significantly higher than that in the non-ischemic type (P = 0.01). Arteriovenous passage time was significantly correlated to the logarithm of the aqueous VEGF concentration (P = 0.0001). MBR of the affected eye / MBR of the unaffected eye of the ischemic type was significantly lower than the non-ischemic type (P = 0.039). Additionally, MBR was significantly correlated both to the logarithm of the aqueous VEGF concentration (P < 0.0001) and to the arteriovenous passage time (P = 0.0001).

Relationships among Ocular Blood Flow Shown by Laser Speckle Flowgraphy, Retinal Arteriosclerotic Change, and Chorioretinal Circulation Time Obtained by Fluorescein Angiography

“…A few research groups reported that the MBR-V in the ONH reflected the early phase of RT [27, 28], but these studies examined only central RVO cases. It thus remains unclear whether the mean blur rate in the optic nerve head as measured by LSFG reflects the circulation time obtained by FA in different ocular diseases.…”

Aqueous humour concentrations of TGF‐β, PLGF and FGF‐1 and total retinal blood flow in patients with early non‐proliferative diabetic retinopathy

“…, ; Yamada et al. ), this is the first study to point to a role of FGF‐1 in impaired retinal blood flow in early DR. Overall, measurement of TRBF using Doppler OCT may be useful for predicting aqueous FGF‐1 levels and severity of hemodynamic disturbances in early DR.…”

“…Recently, aqueous humour (AH) vascular endothelial growth factor (VEGF) was found to be associated with retinal blood flow in patients with central retinal vein occlusion (Yamada et al. ). More recently, the use of multiplex bead analysis allows for simultaneous analysis of multiple cytokines in small volumes and provides broader insight into the mechanisms involved in retinal hemodynamic alterations in early DR.…”

“…Moreover, previous studies have demonstrated that angiogenic cytokines are elevated in the ocular fluid of eyes affected by DR (Oh et al 2010;Chiang et al 2012;Dong et al 2013) and diabetic macular oedema (Jonas et al 2012;Lee et al 2012) compared with control eyes. Recently, aqueous humour (AH) vascular endothelial growth factor (VEGF) was found to be associated with retinal blood flow in patients with central retinal vein occlusion (Yamada et al 2015). More recently, the use of multiplex bead analysis allows for simultaneous analysis of multiple cytokines in small volumes and provides broader insight into the mechanisms involved in retinal hemodynamic alterations in early DR.…”

Recent Clinical Applications of Laser Speckle Flowgraphy in Eyes with Retinal Disease

“…48 Another study found that some cases of central RVO (CRVO) exhibited an increase in MBR in the ONH after IVB. 49 Most recently, MBR in the ONH in CRVO was reported to be correlated both with the aqueous concentration of VEGF and the arteriovenous passage time, 50 suggesting that LSFG may be useful for predicting the aqueous level of VEGF and the severity of CRVO. Thus, LSFG can be used to confirm the effectiveness of drug treatments targeting blood flow in different retinal ischemic diseases, leading to a better understanding of the pathogenesis of these retinal diseases.…”