Comparison of carprofen and meloxicam for 72 hours following ovariohysterectomy in dogs

Okano

et al. 2008

ABSTRACT. Sparing effects of carprofen and meloxicam with or without butorphanol on the minimum alveolar concentration (MAC) of sevoflurane were determined in 6 dogs. Anesthesia was induced and maintained with sevoflurane in oxygen, and MAC was determined by use of a tail clamp method. The dogs were administered a subcutaneous injection of carprofen (4 mg/kg) or meloxicam (0.2 mg/kg), or no medication (control) one hour prior to induction of anesthesia. Following the initial determination of MAC, butorphanol (0.3 mg/ kg) was administered intramuscularly, and MAC was determined again. The sevoflurane MACs for carprofen alone (2.10 ± 0.26%) and meloxicam alone (2.06 ± 0.20%) were significantly less than the control (2.39 ± 0.26%). The sevoflurane MACs for the combination of carprofen with butorphanol (1.78 ± 0.20%) and meloxicam with butorphanol (1.66 ± 0.29%) were also significantly less than the control value after the administration of butorphanol (2.12 ± 0.28%). The sevoflurane sparing effects of the combinations of carprofen with butorphanol and meloxicam with butorphanol were additive.

Section: Discussionmentioning

confidence: 47%

Section: Discussionmentioning

confidence: 99%

Effects of Carprofen and Meloxicam with or without Butorphanol on the Minimum Alveolar Concentration of Sevoflurane in Dogs

Okano

et al. 2008

“…Many of the non-steroidal anti-inflammatory drugs (NSAIDs) have proven to be effective in controlling post-operative pain in dogs when used either alone or in combination with opioids [3,5,8,10,11,13]. However, the administration of NSAIDs may induce gastrointestinal toxicity, compromise renal blood flow, and/or cause hemostatic abnormalities as the results of inhibition of cyclo-oxygenase (COX).…”

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confidence: 99%

Efficacy and Safety of Firocoxib for the Treatment of Pain Associated with Soft Tissue Surgery in Dogs under Field Conditions in Japan

Kondo¹,

Takashima²,

Matsumoto³

et al. 2012

ABSTRACT. Use of firocoxib in dogs for postoperative pain control has not been published in any of the journals in Japan. A field study was conducted to evaluate the efficacy and safety of firocoxib in dogs in controlling pain associated with soft tissue surgery in Japan. The study followed a negative control, double-blind, multicenter clinical efficacy study using a randomized block design. A total of 131 client-owned dogs presented to the clinical practices for soft tissue surgery were enrolled. Sixty-nine dogs were allocated to the firocoxib-treated group and received 5 mg/kg of firocoxib orally on Day 0 before the surgery and once daily through Day 2, while 62 dogs were allocated to the non-treated group handled in a similar manner only without the firocoxib administration. Pain assessment took place on Day 0 before the surgery through Day 2. The primary efficacy variable was a success/failure variable based on whether the dog needed rescue medication (based on pain assessment after the surgery or Investigator's judgment) and a significant difference between firocoxib-treated group (16.4%) and non-treated group (50.0%) (P=0.0031) was observed. There was no adverse event during the study that was considered to be related to the administration of firocoxib. This study indicated the clinical efficacy and safety profile of firocoxib administered to control pain associated with soft tissue surgery under field condition.

“…Many studies have reported the efficacy of preoperative meloxicam treatment in terms of surgical invasiveness [6,8,12,14,20]. In these studies, pain was mainly evaluated based on scoring systems, such as the visual analog scale (VAS) and cumulative pain score (CPS).…”

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confidence: 99%

“…In these studies, pain was mainly evaluated based on scoring systems, such as the visual analog scale (VAS) and cumulative pain score (CPS). However, these parameters were established based on subjective evaluation methods used in humans, and the results for these parameters differ among observers [12]. A study involving human infants reported no correlation between pain assessment by behavioral observation and subjective pain assessment [2].…”

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confidence: 99%

Influence of Preemptive Analgesia with Meloxicam before Resection of the Unilateral Mammary Gland on Postoperative Cardiovascular Parameters in Dogs

Nakagawa

Miyagawa

Takemura

et al. 2007

ABSTRACT. Preemptive analgesia is recommended in small animal medicine. However, many studies have evaluated the response to analgesic treatment by behavioral observation. Therefore, the influence of preemptive analgesia with meloxicam on postoperative cardiovascular and renal parameters remains to be clarified. The present study examined the changes in blood pressure, heart rate, double product and heart rate variability for 14 days and the changes in glomerular filtration rate (GFR) and serum cortisol level for 24 hr after resection of the unilateral mammary gland in meloxicam and control groups consisting of 5 healthy dogs. All data were collected under unanesthetized and unrestrained conditions using a radio telemetry system. Blood pressure, heart rate and double product were significantly lower in the meloxicam compared with the control group, and the meloxicam group's diurnal changes became stable more than 36 hr earlier than those of the control group. The systolic, diastolic and mean blood pressure values of the meloxicam group were 5-to 20-mm Hg lower than those of the control group until 5 days after surgery. The maximum difference between the two groups in terms of the double product values 14 days after surgery was 2,000 bpm × mmHg. Autonomic activity inhibition was prolonged in the control group. There were no significant differences in the 24-hr changes in GFR or serum cortisol level. This study showed that perioperative administration of meloxicam reduced unfavorable postoperative changes in the cardiovascular system without influencing renal function.