Comparison of atmospheric microplasma and plasma jet irradiation for increasing of skin permeability

Shimizu, Kazuo; Tran, N A; Hayashida, K; Blajan, Marius

doi:10.1088/0022-3727/49/31/315201

Cited by 19 publications

(17 citation statements)

References 52 publications

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“…Argon, nitrogen or argon-water vapour gases were introduced into the plasma jet. The waveform of the voltage and current of argon plasma jet is depicted in Figure 8 [72]. …”

Section: Plasma Jetmentioning

confidence: 99%

Enhancement of Percutaneous Absorption on Skin by Plasma Drug Delivery Method

Shimizu¹,

Krištof²

2017

Advanced Technology for Delivering Therapeutics

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Transdermal drug delivery (TDD) is a painless method of low-dose drug delivery. The advantages and disadvantages of transdermal drug delivery methods are named and basic methods such as using chemical enhancers, iontophoresis and electrophoresis are introduced. One of the promising methods make use of plasma which is generated in atmospheric pressure mostly in volume or on surface dielectric barrier discharge (DBD) or in plasma jet. As the plasma produces various particles according to the used gas, UV radiation and heat, their effects on skin and barrier function are described. Improvement of transdermal drug delivery of hydrophilic drug galantamine hydrobromide (GaHBr) using microplasma electrode is introduced.

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“…Argon, nitrogen or argon-water vapour gases were introduced into the plasma jet. The waveform of the voltage and current of argon plasma jet is depicted in Figure 8 [72]. …”

Section: Plasma Jetmentioning

confidence: 99%

Enhancement of Percutaneous Absorption on Skin by Plasma Drug Delivery Method

Shimizu¹,

Krištof²

2017

Advanced Technology for Delivering Therapeutics

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“…Microplasma is a type of dielectric barrier discharge (DBD) atmospheric-pressure plasma that can be generated at a relatively low discharge voltage of about 1 kV. The micrometer-order discharge gap allows microplasma to be generated at atmospheric pressure and voltages from 0.4 kV depending on the discharge parameters [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…Plasma jets also belong to the large family of cold atmospheric pressure plasmas; they are discharged plasma that can extend beyond the plasma generation region into the surrounding ambient environments, and they could be generated at a discharge voltage around 2 kV, with discharge gaps in the order of millimeters [ 19 ]…”

Section: Introductionmentioning

confidence: 99%

Direct and Indirect Bactericidal Effects of Cold Atmospheric-Pressure Microplasma and Plasma Jet

et al. 2021

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The direct and indirect bactericidal effects of dielectric barrier discharge (DBD) cold atmospheric-pressure microplasma in an air and plasma jet generated in an argon-oxygen gas mixture was investigated on Staphylococcus aureus and Cutibacterium acnes. An AC power supply was used to generate plasma at relatively low discharge voltages (0.9–2.4 kV) and frequency (27–30 kHz). Cultured bacteria were cultivated at a serial dilution of 10−5, then exposed to direct microplasma treatment and indirect treatment through plasma-activated water (PAW). The obtained results revealed that these methods of bacterial inactivation showed a 2 and 1 log reduction in the number of survived CFU/mL with direct treatment being the most effective means of treatment at just 3 min using air. UV–Vis spectroscopy confirmed that an increase in treatment time at 1.2% O2, 98.8% Ar caused a decrease in O2 concentration in the water as well as a decrease in absorbance of the peaks at 210 nm, which are attributed NO2− and NO3− concentration in the water, termed denitratification and denitritification in the treated water, respectively.

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“…[18,19] These components may increase the permeability of the skin synthetically. It is reported that the CAP can enhance the TDD efficiency by using plasma jet, [20,21] microplasma, [20] microwave plasma, [22] and air dielectric barrier discharge (DBD) discharge, [23] these reports show that the CAP can modify the skin surface to enhance the permeability of the skin, and the charged particles, [22] power density [23] plays an important role in this process. Nevertheless, its mechanism is not discussed in detail and systematically.…”

Section: Introductionmentioning

confidence: 99%

Cold atmospheric plasma jet array for transdermal drug delivery

Nie

Duan

et al. 2020

Plasma Processes & Polymers

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Transdermal drug delivery (TDD) is an important drug delivery method, and cold atmospheric plasma has been proven its potential as a TDD approach. In this study, a 9-channel plasma jet array was designed to enhance TDD efficiency. The Franz diffusion experiment showed that the TDD efficiency of the drug across the skin was enhanced about 2-110 times after the plasma jet array treatment. The histological analysis showed that the structure of the stratum corneum could be destroyed by the plasma. Further investigations indicated that the reactive oxygen species of the plasma jet play a key role in enhancing TDD efficiency. Our results indicated that the plasma jet array is a potential and effective TDD approach.

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Comparison of atmospheric microplasma and plasma jet irradiation for increasing of skin permeability

Cited by 19 publications

References 52 publications

Enhancement of Percutaneous Absorption on Skin by Plasma Drug Delivery Method

Enhancement of Percutaneous Absorption on Skin by Plasma Drug Delivery Method

Direct and Indirect Bactericidal Effects of Cold Atmospheric-Pressure Microplasma and Plasma Jet

Cold atmospheric plasma jet array for transdermal drug delivery

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