Enhancement of Percutaneous Absorption on Skin by Plasma Drug Delivery Method

Shimizu, Kazuo; Krištof, Jaroslav

doi:10.5772/65116

Cited by 5 publications

(7 citation statements)

References 91 publications

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“…Over the last two decades, many researchers paid attention to CAP to overcome the disadvantages of the conventional drug delivery systems and promote drug penetration. The skin properties can be changed temporarily to improve the drug transportation by CAP through various effects based on its multiple components (ions, heat, UV light, reactive oxygen species, and other reactive radicals) 16 . It has been proved that CAP could promote the percutaneous absorption of various substances and drugs including phenol red, GaHBr, 17 rhodamine B, 18 cyclosporine A, 19 and dextrans 20 in animal models and ex vivo permeation study, 21 whereas few clinical trials can be referred to.…”

Section: Introductionmentioning

confidence: 99%

Analgesic effect of topical lidocaine is enhanced by cold atmospheric plasma pretreatment in facial CO₂ laser treatments

Xin

Wen

Jiang

2021

J of Cosmetic Dermatology

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Background Topical anesthesia is widely used in many dermatological and cosmetic procedures. Nevertheless, the stratum corneum serves as the skin barrier, impedes the transdermal drug delivery greatly, and results in insufficient analgesia. Cold atmospheric plasma (CAP) has been researched as a transdermal drug delivery promoter with ex vivo experiments for a few years, while clinical trials are scarce. Aims To assess the efficacy and safety of CAP as a pretreatment to improve the transdermal absorption of topical anesthetic cream before the CO2 laser treatment for postacne scars in the human body. Patients/Methods Twenty patients, seeking full facial laser treatment for atrophic acne scars, underwent a randomized split‐face study. One side of the face was pretreated by CAP before topical anesthetic cream was applied, and the other side was applied with topical anesthetic cream only as control. After that, the subjects went through full‐face fractional CO2 laser treatment of postacne scars. They were asked to score the pain on a visual analogue scale (VAS) after the laser treatment to measure the anesthesia effects which indicates the transdermal absorption of the cream. Possible adverse effects of the plasma were recorded during the pretreatment including associated pain, heat, erythema, and edema. Results The VAS score of the treated side was statistically lower (5.1 ± 2.1) compared with the nontreated side (6.3 ± 1.9), with a mean difference of 1.3 (95% confidence interval [CI], 0.6‐1.9; P < .0001). No severe adverse event was reported, and all the disturbing sensations and symptoms (pain, heat, and edema) were evaluated as mild with no mean score surpassing 4.0. Conclusion Plasma pretreatment of 5 minutes before topical anesthetic cream application gives significant pain reduction during the laser procedures, showing the potential effects of CAP on promoting transdermal drug delivery, with no obvious adverse effects reported.

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Section: Introductionmentioning

confidence: 99%

Analgesic effect of topical lidocaine is enhanced by cold atmospheric plasma pretreatment in facial CO₂ laser treatments

Xin

Wen

Jiang

2021

J of Cosmetic Dermatology

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“…A higher level of skin resistance is associated with skin integrity and an intact barrier (Rachakonda et al, 2008), influencing methods such as iontophoresis (Roustit, Blaise & Cracowski, 2014). This method employs a non-invasive electric current at low voltages for the delivery of ionisable drugs into the skin (Shimizu & Krištof, 2017).…”

Section: Introductionmentioning

confidence: 99%

Establishment of an in vitro model of cultured viable human, porcine and canine skin and comparison of different media supplements

Bauhammer

Sacha

Haltner

2019

PeerJ

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Transdermal drug delivery provides several advantages over conventional drug administration, such as the avoidance of first-pass metabolism and better patient compliance. In vitro research can abbreviate and facilitate the pharmaceutical development considerably compared to in vivo research as drug screening and clinical studies can be reduced. These advantages led to the development of corresponding skin models. Viable skin models are more useful than non-viable ones, due to the influence of skin metabolism on the results. While most in vitro studies concentrate on evaluating human-based models, the current study is designed for the investigation of both human and animal diseases. So far, there is little information available in the literature about viable animal skin cultures which are in fact intended for application in the veterinary and not the human field. Hence, the current study aims to fill the gap. For the in vitro viable skin model, specimens of human, porcine and canine skin were cultured over two weeks under serum-free conditions. To evaluate the influence of medium supplementation on skin viability, two different supplement mixtures were compared with basic medium. The skin specimens were maintained at a viability-level >50% until the end of the study. From the tested supplements, the addition of bovine pituitary extract and epidermal growth factor increased skin viability whereas hydrocortisone and insulin induced a decrease. This in vitro viable skin model may be a useful tool for the investigation of skin diseases, especially for the veterinary field.

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“…However, the plasma-generated RONS are insufficient for treating various diseases [11]. Therefore, plasma medicine explores treatment not only via CAPs instead of drugs but also via combinations of CAPs and drugs, which can produce effects that cannot be produced by using a CAP or a drug alone [12]. For example, Guo et al found that CAPs could promote the effects of several classes of antibiotics, and hence acted as antibiotic sensitizers for the treatment of antibiotic-resistant bacteria that are involved in infectious diseases [13].…”

Section: Introductionmentioning

confidence: 99%

“…For example, Guo et al found that CAPs could promote the effects of several classes of antibiotics, and hence acted as antibiotic sensitizers for the treatment of antibiotic-resistant bacteria that are involved in infectious diseases [13]. Various reports predicted that the combination of CAPs and drugs may satisfy the requirements for the treatment of various diseases [12,14], and this combination is a promising approach in the field of plasma medicine; however, the mechanism is not well understood, which motivates us to conduct the present study.…”

Section: Introductionmentioning

confidence: 99%

Stimulation of lidocaine penetration into model tissues by an argon plasma jet

He¹,

Liu²,

Xia³

et al. 2019

J. Phys. D: Appl. Phys.

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The transportation of drugs through model tissues that are being treated by an argon plasma jet was investigated in this paper. Gelatin gel films were used to construct the model tissues and lidocaine was used as a representative drug. The argon plasma jet enhanced the penetration of lidocaine and the enhancement rate increased with the discharge voltage and the frequency. When the discharge power of the plasma jet was low, it was deduced that the enhancement effect was mainly attributed to the electric field of the plasma jet. The enhancement effect was holistic and was hindered by the macromolecules of gelatin in the model tissues. When the discharge power of the plasma jet increased beyond a threshold level, the surface streamers of the plasma jet produced a deformation effect in the model tissue, thereby resulting in a starshaped pattern on the surface of the model tissue. In that case, the penetration enhancement of lidocaine was dominated by the deformation effect; however, it was mainly confined to the surface layer. For comparison, a helium plasma jet was also used to enhance the penetration of lidocaine. When the discharge power was low, the enhancement effect of the helium plasma jet was higher than that of the argon plasma jet because the He gas flow and the electric field of He plasma jet enhanced the penetration of lidocaine jointly; however, the enhancement effect of the Ar plasma jet was only attributed to the electric field. When the discharge power increased beyond a threshold level, the enhancement effects of the two plasma jets were almost the same.

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Enhancement of Percutaneous Absorption on Skin by Plasma Drug Delivery Method

Cited by 5 publications

References 91 publications

Analgesic effect of topical lidocaine is enhanced by cold atmospheric plasma pretreatment in facial CO₂ laser treatments

Analgesic effect of topical lidocaine is enhanced by cold atmospheric plasma pretreatment in facial CO₂ laser treatments

Establishment of an in vitro model of cultured viable human, porcine and canine skin and comparison of different media supplements

Stimulation of lidocaine penetration into model tissues by an argon plasma jet

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Enhancement of Percutaneous Absorption on Skin by Plasma Drug Delivery Method

Cited by 5 publications

References 91 publications

Analgesic effect of topical lidocaine is enhanced by cold atmospheric plasma pretreatment in facial CO2 laser treatments

Analgesic effect of topical lidocaine is enhanced by cold atmospheric plasma pretreatment in facial CO2 laser treatments

Establishment of an in vitro model of cultured viable human, porcine and canine skin and comparison of different media supplements

Stimulation of lidocaine penetration into model tissues by an argon plasma jet

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Analgesic effect of topical lidocaine is enhanced by cold atmospheric plasma pretreatment in facial CO₂ laser treatments

Analgesic effect of topical lidocaine is enhanced by cold atmospheric plasma pretreatment in facial CO₂ laser treatments