Comparison of a Point of Care Cholesterol Device and Laboratory Analysis in the Prediction of Cardiovascular Disease

Rao, Nisha; Johri, Nikhil; Robertson, Laura; Harvey, D.; Persaud, Brian; Mikhailidis, D.P.; Thomas, Mark; Nair, Devaki

doi:10.1016/j.atherosclerosis.2009.07.013

Cited by 2 publications

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“…Differences between POC and laboratory measurements were noted for at least 1 lipid value in 9 of the studies. [26][27][28]30,32,33,[35][36][37] Due to the limited studies available and inconsistencies among these studies in terms of accuracy, POC devices should not be used for the diagnosis of hyperlipidemia. Venous laboratory measurements should continue to remain the gold standard for the diagnosis of hyperlipidemia.…”

Section: Discussionmentioning

confidence: 99%

“…Rao et al aimed to determine the differences between the Cholestech LDX and the Roche modular method (a routine laboratory method) for analyzing serum samples in predicting cardiovascular disease (CVD) risk. 30 Forty-nine paired samples were analyzed using these 2 methods. The study authors used the Joint British Societies’ 2 (JBS 2) CVD chart to predict CVD risk.…”

Section: Devicesmentioning

confidence: 99%

“…Twelve studies discussed the accuracy of cholesterol POC devices. [26][27][28][29][30][31][32][33][34][35][36][37] Ten of the 12 studies evaluated Cholestech LDX in comparison to hospital reference laboratory measurements. Shemesh et al aimed to test the accuracy of POCT results from mass screenings in remote Australian communities.…”

Section: Accuracy Of Poc Devicesmentioning

confidence: 99%

“…The study authors concluded that POC analyzers are able to accurately identify individuals with abnormal cholesterol blood levels. 29 Rao et al aimed to determine the differences between the Cholestech LDX and the Roche modular method (a routine 30 Jain et al described a national CVD risk assessment initiative in London. 31 This study aimed to test the accuracy of POCT results for this mass screening initiative.…”

Section: Accuracy Of Poc Devicesmentioning

confidence: 99%

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Cholesterol Point-of-Care Testing for Community Pharmacies: A Review of the Current Literature

Haggerty

Tran

2016

Journal of Pharmacy Practice

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The current literature suggests that POCTs in community pharmacies assist with patient outcomes by providing screenings and referring patients with dyslipidemia for further evaluation. The majority of studies on cholesterol POC devices focused on accuracy, revealing the need for further studies to develop best practices and practice models with successful reimbursement. Accuracy, device specifications, required supplies, and patient preference should be considered when selecting a POC device for purchase.

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Section: Discussionmentioning

confidence: 99%

Section: Devicesmentioning

confidence: 99%

Section: Accuracy Of Poc Devicesmentioning

confidence: 99%

Section: Accuracy Of Poc Devicesmentioning

confidence: 99%

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Cholesterol Point-of-Care Testing for Community Pharmacies: A Review of the Current Literature

Haggerty

Tran

2016

Journal of Pharmacy Practice

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“…A point of care device that measures HDL- 15 C directly is very attractive in biomedical diagnostics and would be highly advantageous in the self-management of hypercholesterolemia. [12][13][14] Electrochemical techniques lend themselves well to the fabrication of low cost, point of care and disposable diagnostic devices. Thus, it would seem a common 20 sense approach to develop electrochemical biosensor methodologies that are capable of measuring HDL-C using a similar principle, with the measurement of H 2 O 2 performed electrochemically.…”

Section: Introductionmentioning

confidence: 99%

A biosensor for the determination of high density lipoprotein cholesterol employing combined surfactant-derived selectivity and sensitivity enhancements

2014

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A biosensor for the determination of high density lipoprotein cholesterol employing combined surfactant-derived selectivity and sensitivity enhancements. Analytical Methods, 6. pp. 3975-3981. ISSN 1759-9660 Available from: http://eprints.uwe.ac.uk/23377We recommend you cite the published version. The publisher's URL is: http://dx.doi.org/10.1039/C3AY42262C Refereed: YesPublished online first 7 Mar 2014 Disclaimer UWE has obtained warranties from all depositors as to their title in the material deposited and as to their right to deposit such material. UWE makes no representation or warranties of commercial utility, title, or fitness for a particular purpose or any other warranty, express or implied in respect of any material deposited. UWE makes no representation that the use of the materials will not infringe any patent, copyright, trademark or other property or proprietary rights. UWE accepts no liability for any infringement of intellectual property rights in any material deposited but will remove such material from public view pending investigation in the event of an allegation of any such infringement. PLEASE SCROLL DOWN FOR TEXT.Journal Name High density lipoprotein cholesterol (HDL-C) is a modifiable risk factor in cardiovascular disease and devices suitable for its determination at the point of care are critical to the future management of hypercholesterolaemia. An electrochemical biosensor for measuring HDL-C was developed. The 10 biosensor was based on a homogeneous assay methodology for selective determination of HDL-C in combination with a printed electrochemical sensor for measuring the reduction of hydrogen peroxide at a silver paste electrode. The polyoxyethylene alkylene tribenzylphenyl ether surfactant (Emulgen B-66) was found to be capable of both the selective dissolution of HDL particles, as well as the enhanced electrocatalytic reduction of hydrogen peroxide. The resulting biosensor was shown to have a linear 15 response to HDL-C from 0.5 to 4 mM (r 2 =0.998) with an average r.s.d. of 7%. The biosensor was also used to analyse HDL-C in thirteen serum samples and had good agreement with a commercial spectrophotometric precipitation-based assay (r=0.7222; p < 0.058). IntroductionCholesterol levels, including high density lipoprotein cholesterol 20 (HDL-C) are modifiable risk factors for cardiovascular disease (CVD), a condition which remains the number one global cause of death. 1-3 Levels of HDL-C above 60 mg/dL (1.55 mM) are considered to have a positive protective role in heart disease, while low HDL-C levels (less than 40 mg/dL or about 1 mM) are 25 linked to an increase in heart attack risk. For this reason, the importance of measurement of HDL-C has been emphasized by the National Cholesterol Education Programme (NCEP) since the late 1980s. 4,5 The measurement of HDL-C is also important for two other purposes: Network (CRMLN) developed a simpler method based on a modified dextran sulphate procedure. 8 However, this technique, like the CDC method, also required large sample volumes and a...

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Comparison of a Point of Care Cholesterol Device and Laboratory Analysis in the Prediction of Cardiovascular Disease

Cited by 2 publications

References 0 publications

Cholesterol Point-of-Care Testing for Community Pharmacies: A Review of the Current Literature

Cholesterol Point-of-Care Testing for Community Pharmacies: A Review of the Current Literature

A biosensor for the determination of high density lipoprotein cholesterol employing combined surfactant-derived selectivity and sensitivity enhancements

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