Comparison between Micro-Computed Tomography and Cone-Beam Computed Tomography in the Assessment of Bone Quality and a Long-Term Volumetric Study of the Augmented Sinus Grafted with an Albumin Impregnated Allograft

Abstract

The purpose of our study was to compare micromorphometric data obtained by cone-beam computed-tomography (CBCT) and microcomputed-tomography (micro-CT) of the augmented sinus and to evaluate the long-term stability of the bone gain achieved using BoneAlbumin. Sinus lifts, and after 6-months, healing bone-biopsy and implant placement were carried out. Specimens were analyzed by micro-CT. A total of 16 samples were collected from nine patients (mean age 54.7 ± 6.5 years). Pre-, postoperative, and 3-year control CBCT-data were registered to determine from where the biopsy samples were harvested. Micromorphometric variables were calculated from the micro-CT- and CBCT-data, and their correlation was determined by Spearman’s test. The volume of augmented bone was calculated at the time of implant placement and after 3 years. A positive correlation was found between bone-volume fraction, trabecular-separation, open-, and total-porosity, while a negative correlation was found between trabecular-thickness obtained from CBCT- and micro-CT-data (p < 0.05). Mean volumetric reduction of 39.28% (11.88–60.02%) was observed. Correlation of CBCT- and micro-CT-data suggested that micromorphometric analysis of CBCT reconstructions of the augmented sinuses provided reliable information on the microarchitecture of augmented bone. CBCT as a modality might be adequate in the analysis of bone quality in the augmented sinus. At the 3-year, control sinus grafts showed volumetric stability.

Alveolar Preservation with Albumin and Gentamycin-Coated Allograft after Third Molar Tooth Removal: A Randomized Clinical Trial

“…These results are consistent with the results of a previous CBCT study based on T.bTh values, however the observed Po(tot) values seem to be different, which might be due to different voxel sizes were used in the two studies. [41]. The microCT data of Kivovics et al are positively correlated with our CBCT results in regard of Po(tot) values, which might be caused by the higher resolution of CBCT imaging in the present investigation.…”

“…Micromorphometry analysis of CBCT images are reliable indicators of bone morphology, and its measurements correlate positively with microCT analysis of bone core biopsy samples [41]. BS/BV refers to the volume ratio of calcified tissues Po(tot) shows the total volume of open and closed pores [42].…”

The Influence of Surgical Experience and Bone Density on the Accuracy of Static Computer-Assisted Implant Surgery in Edentulous Jaws Using a Mucosa-Supported Surgical Template with a Half-Guided Implant Placement Protocol—A Randomized Clinical Study

“…Bone density measurements derived from CBCT reconstructions are inaccurate and should be generally avoided because of the artefacts and variable scanning conditions [ 36 , 37 , 38 ]. The literature suggests that micro-morphometric measurements based on CBCT data may be a reliable predictor of bone quality [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. Consequently, in the present study, in addition to the grey level measurements of the CAIS software, bone density was determined by BV/TV measurements on the preoperative CBCT.…”

Evaluation of the Histomorphometric and Micromorphometric Performance of a Serum Albumin-Coated Bone Allograft Combined with A-PRF for Early and Conventional Healing Protocols after Maxillary Sinus Augmentation: A Randomized Clinical Trial

“…It has been proven that albumin is necessary for early bone healing processes and is physiologically present in native bone [ 40 ]. Previous studies with SACBAs in the field of orthopedics and oral surgery have reported uncomplicated healing with a high degree of graft remodeling [ 17 , 19 , 41 ].…”