Evaluation of the Histomorphometric and Micromorphometric Performance of a Serum Albumin-Coated Bone Allograft Combined with A-PRF for Early and Conventional Healing Protocols after Maxillary Sinus Augmentation: A Randomized Clinical Trial

Trimmel, Bálint; Gyulai-Gaál, Szabolcs; Kivovics, Márton; Jákob, Noémi; Hegedűs, Csaba; Szabó, Bence; Dobó‐Nagy, Csaba; Szabó, György

doi:10.3390/ma14071810

Cited by 11 publications

(11 citation statements)

References 51 publications

(36 reference statements)

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“…The newly formed bone at 4 months after MSFA using DBB with leukocytes and PRF was significantly greater than at 8 months after MSFA using DBB only [ 36 ]. Similarly, with the use of advanced PRF, no significant differences were observed in bone healing at the implant site and in implant stability between the healing periods of 3 months after MSFA and 6 months after MSFA [ 37 ]. In addition, heterologous bioactive proteins, such as recombinant human platelet-derived growth factor and rhBMPs, were also evaluated for potential in enhanced bone healing after MSFA [ 31 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical and radiographic outcomes of dental implant after maxillary sinus floor augmentation with rhBMP-2/hydroxyapatite compared to deproteinized bovine bone

et al. 2022

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Objectives This study aimed to evaluate the clinical and radiographic outcomes of early implant placement and functional loading in maxillary sinus floor augmentation (MSFA) using recombinant human bone morphogenetic protein 2/hydroxyapatite (rhBMP-2/HA) and to compare these outcomes with those of the conventional protocol in MSFA using deproteinized bovine bone (DBB). Materials and methods The rhBMP-2/HA and DBB groups consisted of 14 and 13 patients who underwent MSFA with BMP and DBB, respectively. After placement of 22 implants and 21 implants in the rhBMP-2/HA and DBB groups, respectively, abutment connections were performed 3 months after implant placement for the rhBMP-2/HA group and 6 months after implant placement for the DBB group. Changes in grafted sinus height (GSH), marginal bone loss (MBL), and implant stability were evaluated up to one year after functional loading. Results Survival rates for the rhBMP-2/HA and DBB groups after one year of functional loading were 90.9% and 90.5%, respectively. Both groups exhibited no significant time-course changes in GSH until one year of functional loading (rhBMP-2/HA, p = 0.124; DBB, p = 0.075). Although significant MBL occurred after one year of functional loading for both groups (rhBMP-2/HA, p < 0.001; DBB, p < 0.001), there were no significant differences in time-course changes in MBL between the two groups (p = 0.450). The mean implant stability quotient values in the rhBMP-2/HA and DBB groups were 75.3 and 75.4 after one year of functional loading, respectively, and there were no significant differences between the two groups (p = 0.557). Conclusions MSFA using rhBMP-2/HA allowed implant rehabilitation with early implant placement and functional loading and led to a comparable survival rate and implant stability after 1 year of functional loading with acceptable MBL and stable maintenance of GSH compared to the MSFA using DBB with 6 months of healing after implant placement.

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Section: Discussionmentioning

confidence: 99%

Clinical and radiographic outcomes of dental implant after maxillary sinus floor augmentation with rhBMP-2/hydroxyapatite compared to deproteinized bovine bone

et al. 2022

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“…However, the stability of both PRF alone and PRF composites at long term studies are still unknown (79). Besides, advanced platelet-rich fibrin (A-PRF) and Leukocyte-platelet-rich fibrin (L-PRF) also have been used widely for bone tissue engineering (81)(82)(83)(84)(85)(86)(87). Fig.…”

Section: Development Of Fibrin Composite In Mimicking Bone Tissuementioning

confidence: 99%

Angiogenic and Osteogenic Properties of Fibrin in Bone Tissue Engineering

Maaruf¹,

Jusoh²

2022

MJMHS

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The bone scaffold has become a promising alternative in bone tissue engineering due to the limitation associated with current bone treatments. However, the selection of scaffold material that could accurately mimic the extracellular matrix of native tissue remains challenging. Owing to its biological origin properties, natural materials including fibrin are widely used as scaffold materials as compared to synthetic materials. Fibrin has been recognized as one of the appealing natural biopolymers, which possesses unique characteristic due to its natural formed nano-scaffold, which provide a temporary matrix that facilitates cellular activities of cells. Fibrin has shown remarkable effects over other biomaterials in inducing angiogenesis and osteogenesis in bone regeneration owing to its mechanical and biological properties. In this article, we highlight the significance of fibrin materials in facilitating bone regeneration. We focus on the manipulation of fibrin composition and on the recent developments of fibrin composites in enhancing osteogenesis and angiogenesis for bone healing.

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“…Alkalmazásával elkerülhető a sebgyógyulás zavara, továbbá a relapsusok aránya is jelentősen csökkent [26,27]. Kimutatták, hogy a PRF újabb generációjának (advanced PRF -A-PRF) csontpótlóval történő együttes alkalmazása csökkentheti a sinus maxillaris augmentációt követő implantációhoz szükséges gyógyulási időt [28].…”

Section: Rövidítésekunclassified

Vérlemezkében gazdag fibrinnel kezelt parodontalis csontdefektusok gyógyulásának értékelése

Csifó-Nagy

Paár

Dőri

2022

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Összefoglaló. Az autológ vérlemezke-koncentrátumok az orvoslás egyre több területén kerülnek alkalmazásra. A vérlemezkében gazdag fibrin, ebben a kategóriában, az adott terápiás lehetőségek közül a legaktuálisabb. Előnyei, hogy alvadásgátló hozzáadása nélkül preparálható, egy centrifugálást igényel, és több formában alkalmazható. A vérlemezkében gazdag fibrin újabb generációja további lehetőségeket teremthet, így a parodontalis sebgyógyulás terén is. Az esetek bemutatásának célja parodontalis intraossealis csontdefektusok gyógyulásának rövid távú klinikai értékelése autológ vérlemezkében gazdag készítménnyel (advanced platelet-rich fibrin) történt kezelést követően. A bemutatott eseteknél preoperatíven, majd 6 hónappal a műtétet követően történt kiértékelés a következő parodontológiai paraméterek rögzítésével: tasakszondázási mélység (probing depth), illetve klinikai tapadási szint (clinical attachment level). Teljes vastagságú lebenyek képzését követően a csontdefektus kürettálása, illetve gyökérsimítás történt, majd a preoperatíven preparált, vérlemezkében gazdag fibrin applikálására került sor, melyet sebzárás követett. Fél évvel a sebészi beavatkozás után a szondázási mélység csökkenése és a klinikai tapadási nívó növekedése volt tapasztalható. Bemutatott eseteinknél a vérlemezkében gazdag fibrin applikációja pozitív klinikai eredményeket mutatott a parodontalis sebgyógyulás tekintetében. A vérlemezkében gazdag fibrinnek mint humán autológ preparátumnak a használata elősegítheti a parodontalis defektusok sikeres kezelését. Orv Hetil. 2022; 163(12): 484–490. Summary. Autologous platelet concentrates are being used in more and more areas of medicine. Application of platelet-rich fibrin is the most topical among these therapeutic options. As main advantages, it can be prepared without the addition of anticoagulants, requires only one centrifugation and can be used in various forms. A new generation of platelet-rich fibrin may open up further opportunities, including those in periodontal wound healing. The aim of this case series is to provide a short-term clinical evaluation of the healing of periodontal intrabony defects after treatment with an autologous platelet-rich fibrin product (advanced platelet-rich fibrin). The presented cases were evaluated preoperatively and 6 months after surgery by recording the following periodontal parameters: probing depth and clinical attachment level. After full-thickness flap preparation, intrabony defect curettage, scaling and root planing were performed, followed by the application of preoperatively prepared platelet-rich fibrin and wound closure. Six months after surgery, pocket depth reductions and clinical attachment level gains were observed. In our presented cases, the platelet-rich fibrin application showed positive clinical results regarding periodontal wound healing and may facilitate the successful treatment of periodontal defects. Orv Hetil. 2022; 163(12): 484–490.

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Evaluation of the Histomorphometric and Micromorphometric Performance of a Serum Albumin-Coated Bone Allograft Combined with A-PRF for Early and Conventional Healing Protocols after Maxillary Sinus Augmentation: A Randomized Clinical Trial

Cited by 11 publications

References 51 publications

Clinical and radiographic outcomes of dental implant after maxillary sinus floor augmentation with rhBMP-2/hydroxyapatite compared to deproteinized bovine bone

Clinical and radiographic outcomes of dental implant after maxillary sinus floor augmentation with rhBMP-2/hydroxyapatite compared to deproteinized bovine bone

Angiogenic and Osteogenic Properties of Fibrin in Bone Tissue Engineering

Vérlemezkében gazdag fibrinnel kezelt parodontalis csontdefektusok gyógyulásának értékelése

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