Clinical and radiographic outcomes of dental implant after maxillary sinus floor augmentation with rhBMP-2/hydroxyapatite compared to deproteinized bovine bone

Abstract

Objectives This study aimed to evaluate the clinical and radiographic outcomes of early implant placement and functional loading in maxillary sinus floor augmentation (MSFA) using recombinant human bone morphogenetic protein 2/hydroxyapatite (rhBMP-2/HA) and to compare these outcomes with those of the conventional protocol in MSFA using deproteinized bovine bone (DBB). Materials and methods The rhBMP-2/HA and DBB groups consisted of 14 and 13 patients who underwent MSFA with BMP and DBB, respectively. After placement of 22 implants and 21 implants in the rhBMP-2/HA and DBB groups, respectively, abutment connections were performed 3 months after implant placement for the rhBMP-2/HA group and 6 months after implant placement for the DBB group. Changes in grafted sinus height (GSH), marginal bone loss (MBL), and implant stability were evaluated up to one year after functional loading. Results Survival rates for the rhBMP-2/HA and DBB groups after one year of functional loading were 90.9% and 90.5%, respectively. Both groups exhibited no significant time-course changes in GSH until one year of functional loading (rhBMP-2/HA, p = 0.124; DBB, p = 0.075). Although significant MBL occurred after one year of functional loading for both groups (rhBMP-2/HA, p < 0.001; DBB, p < 0.001), there were no significant differences in time-course changes in MBL between the two groups (p = 0.450). The mean implant stability quotient values in the rhBMP-2/HA and DBB groups were 75.3 and 75.4 after one year of functional loading, respectively, and there were no significant differences between the two groups (p = 0.557). Conclusions MSFA using rhBMP-2/HA allowed implant rehabilitation with early implant placement and functional loading and led to a comparable survival rate and implant stability after 1 year of functional loading with acceptable MBL and stable maintenance of GSH compared to the MSFA using DBB with 6 months of healing after implant placement.

Clinical and radiographic outcomes of lateral sinus floor elevation with simultaneous hydrophilic implants placement: A retrospective study of 2–5 years

“…The mature bone in the grafted area and the reduction in the amount and resorptive activity of osteoclasts slowed down the bone reduction. However, some studies reported that the apparent bone resorption also occurred within 6 months after loading (Han et al., 2022; Jung et al., 2010), indicating that functional remodeling might be another factor affecting bone reduction. This period of quicker reduction was not detected in the present study which might be due to the strict standard of occlusion adjustment.…”

“…The mature bone in the grafted area and the reduction in the amount and resorptive activity of osteoclasts slowed down the bone reduction. However, some studies reported that the apparent bone resorption also occurred within 6 months after loading (Han et al, 2022;Jung et al, 2010) Implant surface (hydrophobic/hydrophilic) −0.425 (−0.814, −0.036) .033* Note: Use single-factor linear analysis to select the possible influencing factors (p < .20), then make multi-factor linear analysis to select the influencing factors (p < .05).…”

Twenty‐five years of recombinant human growth factors rhPDGF‐BB and rhBMP‐2 in oral hard and soft tissue regeneration

“…RhBMP-2 has been recognized as a potent growth factor to induce bone regeneration (Figure 1). 30,[35][36][37][38][39] As follows, the succeeding paragraphs describe the main clinical applications and related outcomes in bone augmentative oral procedures.…”