Comparision of thiopentone sodium and propofol in ECT anaesthesia

Omprakash, TM; Ali, Mohd Inayat; Bhatt, Anand; Devi, M. Gowri; Pasupuleti, Surender

doi:10.4103/0253-7176.43134

Cited by 13 publications

(18 citation statements)

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“…This correlated with previous studies. 4,8,9 A study by Shah et al shows a high incidence of gag reflex, coughing and vomiting in those induced with thiopentone 4 No such effect was seen in our study. Propofol injection caused pain on injection in 20% and thrombophlebitis in 3.3% of the patients.…”

Section: Discussioncontrasting

confidence: 56%

Thiopentone versus propofol-anaesthetic of choice in patients undergoing modified electroconvulsive therapy

2017

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Background: The use of electroconvulsive therapy (ECT) as a treatment modality has increased over the recent years. This is largely due to the use of general anaesthetics, which reduces the physical and psychological trauma associated with the procedure. We attempted to compare the hemodynamic variations and recovery characteristics, along with their effect on seizure quality in patients induced with Thiopentone /Propofol, for Modified ECT.Methods: This was a prospective, randomised controlled study, involving 80 patients. Patients in group 1 received Thiopentone 5 mg/kg, while patients in group 2 received Propofol 1 mg/kg. The hemodynamic status and recovery status were monitored in both the groups for the first thirty minutes. Seizural duration were also recorded. Data was analysed using Students t-test and Pearson Chi-square test.Results: The induction time as well as recovery time was found to be significantly lesser (p <0.05) in the propofol group. The hemodynamic response to was blunted and returned to baseline levels within 10-15 minutes after ECT in the propofol group, whereas it persisted even after 30 minutes in the thiopentone group. There was however, no significant difference in the duration of the seizural activity(p> 0.05).Conclusions: The quick and smooth induction, transient changes in hemodynamics, rapid recovery profile and minimal effects on the seizure quality altogether makes Propofol the preferred anaesthetic agent in Modified ECT.

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Section: Discussioncontrasting

confidence: 56%

Thiopentone versus propofol-anaesthetic of choice in patients undergoing modified electroconvulsive therapy

2017

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“…Increased in heart rate, SBP and DBP after ECT were observed in both groups, but propofol blunts the sympathetic response, so there was less increase in HR, SBP and DBP with propofol. Various authors, the significant rise in HR after ECT with thiopentone as compared to propofol was also noted by Omprakash et al [6] (In both groups, there were transient increase in PR after induction from 85.46 to 115.87 in P group and from 85.46 to 115.57 in T group.). Alok Kumar et al [15] (In group P, an increase in all haemodynaemic parameters was seen after the procedure, mean heart rate (80 ± 14 bpm vs. 76 ± 14bpm), In group T too, a similar trend of increase in all hemodynaemic parameters was seen after the procedure, mean HR (81 ± 12bpm vs. 70 ± 11bpm).…”

Section: Discussionmentioning

confidence: 53%

“…Jain et al [7] (Mean seizure duration 94 ± 21 with P group vs. 83 ± 34 seconds with T group, P value <0.01 is significant. ), Omprakash et al [6] (Propofol had shorter seizure duration as compared to Thiopentone group, P value less than 0.05 is significant, elevation of seizure threshold after propofol administration may explain the lower duration of seizure [17], Daria et al [13] (Mean seizure duration was found less in propofol as 25.6seconds while in thiopentone it was found 28.1 seconds and on comparison this difference was found non significant), Zaidi et al [16] (The mean duration of seizure was 31.08seconds ± 4.13 with thiopentone and 23.76 ± 3.38seconds with propofol (p<0.001)). There is no effect on therapeutic outcome or ECT therapy as observed in previous studies [7].…”

Section: Discussionmentioning

confidence: 99%

“…Thiopentone is well accepted induction agent for ECT. It has rapid smooth induction, good anticonvulsant activity, less effects on seizure duration but associated with side effects like prolonged awakening time, arrhythmias, laryngeal spasm, porphyria, hypersensitivity to thiopentone sodium and post ECT nausea vomiting [6]. Propofol can be used where Thiopentone is contraindicated.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of thiopentone sodium and propofol for anaesthesia in modified Electro-Convulsive Therapy (ECT)

Patel

Upadhyaya

Shah

et al. 2015

Int Jour of Biomed Res

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Objectives: To compare the effects of thiopentone sodium and propofol as an intravenous anaesthetic agent in modified ECT. Methods: 30 patients of ASA I & II grade were randomly assigned in to two groups. Both groups were premedicated in ususal manner. Patients were induced with inj. thiopentone sodium 3-5mg/kg (Group T) and inj. Propofol 1.5-2mg/kg (group P) according to the groups. Then, Inj. Succinyl choline 0.5-1mg/kg was given. Patients were ventilated with 100% oxygen with bain circuit and mask. Shock was given after putting bite block. Patients were again ventilated till spontaneous respiration after seizures. Results: Propofol is better induction agent as compared to thiopentone sodium in terms of faster induction, better haemodynaemic stability, no significant effect on seizure duration, early recovery without any side effects. Conclusion: Propofol in the dosage of 1.5-2 mg/kg body weight intravenously can be safely used for modified ECT in ASA grade I and II pateints. Fast, smooth induction, better hemodynamics, early smooth recovery, antiemetic property and uncompromised therapeutic outcome makes propofol as an agent of choice for day care procedure. Though there is reduced seizure duration with Propofol as compared to thiopentone, there is no effect on outcome of the therapy or effectiveness of ECT.

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“…[3] Significant side effects of thiopental are laryngeal spasm and respiratory depression. [4] Benign allergic skin reactions are common, but a serious allergic reaction is rare.…”

mentioning

confidence: 99%

Comparison of Etomidate and Thiopentone Sodium as Anaesthetic Agents for Modified Electroconvulsive Therapy

Donthu¹,

Kavya²,

Subramanyam³

2017

jemds

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Comparision of thiopentone sodium and propofol in ECT anaesthesia

Cited by 13 publications

References 0 publications

Thiopentone versus propofol-anaesthetic of choice in patients undergoing modified electroconvulsive therapy

Thiopentone versus propofol-anaesthetic of choice in patients undergoing modified electroconvulsive therapy

Comparison of thiopentone sodium and propofol for anaesthesia in modified Electro-Convulsive Therapy (ECT)

Comparison of Etomidate and Thiopentone Sodium as Anaesthetic Agents for Modified Electroconvulsive Therapy

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