Comparing Sensitivity and Specificity of Addenbrooke’s Cognitive Examination-I, III and Mini-Addenbrooke’s Cognitive Examination in Parkinson’s Disease

Lucza, Tivadar; Ascherman, Zsuzsanna; Kovács, Márton; Makkos, Attila; Harmat, Márk; Juhász, Annamária; Janszky, József; Komoly, Sámuel; Kovács, Norbert; Dorn, Krisztina; Karádi, Kázmér

doi:10.1155/2018/5932028

Cited by 12 publications

(17 citation statements)

References 58 publications

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“…Overall, there was no apparent trend across participants in terms of improvements before and after training on the Parkinson's Disease Quality of Life Inventory-39 [27]. The Lille Apathy Rating Scale [30] scores overall indicated a trend towards participants becoming less apathetic, and 3/4 of participants had a lower score at T3 compared to T1 (higher scores represent a greater degree of apathy).…”

Section: Resultsmentioning

confidence: 99%

“…Premorbid IQ and verbal ability were measured using the National Adult Reading Test [25] and Mill Hill verbal fluency test [26], respectively. The performance of the participants on the ACE-R scale does not suggest the presence of MCI based on the proposed cutoff score of 85.5 [27, 28]. All participants were receiving combined levodopa and dopamine agonist therapy and had been stable on their medication regimen for at least four weeks prior to the start of the training.…”

Section: Methodsmentioning

confidence: 99%

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Feasibility and Acceptability of Computerised Cognitive Training of Everyday Cognition in Parkinson’s Disease

Smith

McMillan

Leroi

et al. 2019

Parkinson's Disease

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Objectives. We piloted a computerised cognitive training battery in a group of participants with Parkinson’s disease without dementia to investigate the relevance of the training to daily life and the feasibility and the acceptability of the tasks. Previous studies of CT have had limited success in the benefits of training, extending to improvements in everyday function. By taking a pragmatic approach and targeting training to the cognitive skills affected by Parkinson’s disease (planning, attention, and recollection), whilst using tasks that emulated real-life scenarios, we sought to understand whether participants perceived the training to be effective and to identify the elements of the training that elicited beneficial effects. Methods. Four participants completed a cognitive training session comprising three distinct tasks 5 days a week over two weeks. Participants completed baseline questionnaires examining health-related quality of life, everyday cognition, and apathy before the training period, after the last session, and two weeks after the last session. An interview was held after participants had completed the training. Results. The findings indicated that participants felt the training was acceptable, enhanced their awareness, and encouraged them to monitor their thinking abilities. The group interview indicated that the training was feasible; participants felt the tasks had potential to improve everyday performance, but more supporting information should be provided to facilitate this transfer. Responses to the questionnaires reflected these findings, indicating improvement for some participants’ cognition and quality of life. Objective measures supported the subjective reports; there were improvements in some but not all domains. Performance on the planning and recollection tasks improved over the training period, and the evidence for improvement on the attention task was mixed. Conclusion. This study has found that pragmatic computer-based training with real-life outcomes is both feasible and acceptable and should be evaluated more extensively using controlled methods.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Feasibility and Acceptability of Computerised Cognitive Training of Everyday Cognition in Parkinson’s Disease

Smith

McMillan

Leroi

et al. 2019

Parkinson's Disease

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“…To assess nonmotor symptoms globally, the validated Hungarian version of the NMSS [12] was also included. Besides, neurocognitive performance, apathy, anxiety, and depression were also assessed by the MoCA [13, 14], the Lille Apathy Rating Scale [15], the Parkinson Anxiety Scale [16], the Montgomery–Asberg Depression Rating Scale [17], and the Parkinson's Disease Sleep Scale 2nd version [18, 19]. The 39-item Parkinson's Disease Questionnaire [20] was used to measure the disease-specific health-related quality of life.…”

Section: Methodsmentioning

confidence: 99%

The Parkinson’s Disease Composite Scale Is Adequately Responsive to Acute Levodopa Challenge

Pintér

Martinez‐Martín

Janszky³

et al. 2019

Parkinson's Disease

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Background. The Parkinson’s Disease Composite Scale (PDCS) is a recently developed easy-to-use tool enabling a timely but comprehensive assessment of Parkinson’s disease (PD)-related symptoms. Although the PDCS has been extensively validated, its responsiveness to acute levodopa challenge has not been demonstrated yet. Objective. To investigate the correlation between changes in the motor examination part of the Movement Disorder Society-sponsored Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) and the PDCS motor scores during acute levodopa challenge and calculate a cutoff range on the PDCS indicating clinically relevant improvement. Methods. A consecutive series of 100 patients with parkinsonism were assessed using the motor examination sections of the MDS-UPDRS and the PDCS at least 12 hours after the last levodopa dose and after the administration of a single dose of a suprathreshold immediate formulation of levodopa/benserazide reaching the “best ON.” Results. There was a high correlation between changes in the MDS-UPDRS and the PDCS motor scores (Spearman’s rho = 0.73, p<0.001). Receiver operating characteristic analysis revealed that a 14.6%–18.5% improvement in the PDCS motor scores corresponds to a 20–30% improvement in the MDS-UPDRS motor examination. Conclusions. The PDCS can reliably and adequately respond to an acute levodopa challenge. Any improvements in PDCS motor scores exceeding the 14.6–18.5% threshold could represent a clinically relevant response to levodopa.

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“…Due to these reasons an easy-to-take, validated neurocognitive test with good specificity and sensitivity would be even more essential in order to assess mild cognitive impairment and dementia accurately. Compared to the Anglo-Saxon areas, there is a smaller number of cognitive tests obtainable in Hungary for screening and assessing cognitive decline in patients, however, there are some validated and screened clinical tests available to assess cognitive disabilities specifically among persons with Parkinson's disease such as the Addenbrooke's Cognitive Examination-III, the Mini-Addenbrooke's Cognitive Examination, Frontal Assessment Battery, Mattis Dementia Rating Scale [2], and the Montreal Cognitive Assessment [3,4]. Additionally, the Montreal Cognitive Assessment (MoCA) [5], the Paired Associates Learning (PAL) tests [6] are available for "normal", i.e.…”

Section: Introductionmentioning

confidence: 99%

Validation of the Hungarian Version of Addenbrooke's Cognitive Examination for Detecting Major and Mild Neurocognitive Disorders

Kaszás

Fekete

2020

INDJ

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Aim: The screening of cognitive decline is a mandatory step in the early diagnosis and appropriate treatment of dementia to begin. In order to achieve this, an easy-to-take, validated neurocognitive test with good specificity and sensitivity are essential in the assessment. The aim of this study was to evaluate the Hungarian version of Addenbrooke’s Cognitive Examination (version I., ACE)- by comparing it with the conventional Mini-Mental State Examination (MMSE)- as a new form of assessment in order to screen for early dementia among the elderly. Study Design: Descriptive cross-sectional. Place and Duration of Study: This study is a part of a larger research, conducted among voluntary elderly from the city of Pécs (Hungary) between January 2016 and December 2018. Methodology: The study refers to 66 patients with mild neurocognitive disorder (NCD), 51 patients with major NCD, and 133 healthy participants. The Diagnostic and Statistical Manual of Mental Disorders (version 5.) criteria were used for the diagnosis of dementia. Statistical analysis was performed using the receiver operator characteristics method. Results: The optimal cut-off score for the ACE-I for detecting mild NCD was 82, with a sensitivity of 89% and a specificity of 96%. The optimal cut-off for the ACE for identifying major NCD was 76 with sensitivity of 98% and a specificity of 98%. Conclusion: We concluded that the Hungarian version of the ACE is an accurate test for the detection of NCD, and could be adopted in various clinical practices.

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Comparing Sensitivity and Specificity of Addenbrooke’s Cognitive Examination-I, III and Mini-Addenbrooke’s Cognitive Examination in Parkinson’s Disease

Cited by 12 publications

References 58 publications

Feasibility and Acceptability of Computerised Cognitive Training of Everyday Cognition in Parkinson’s Disease

Feasibility and Acceptability of Computerised Cognitive Training of Everyday Cognition in Parkinson’s Disease

The Parkinson’s Disease Composite Scale Is Adequately Responsive to Acute Levodopa Challenge

Validation of the Hungarian Version of Addenbrooke's Cognitive Examination for Detecting Major and Mild Neurocognitive Disorders

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