Comparing Dynamics and Determinants of Severe Acute Respiratory Syndrome Coronavirus 2 Transmissions Among Healthcare Workers of Adult and Pediatric Settings in Central Paris

Contejean, Adrien; Leporrier, J.; Canouï, Etienne; Alby-Laurent, Fanny; Lafont, Emmanuel; Beaudeau, Lauren; Parize, Perrine; Lecieux, Fabienne; Greffet, Agnès; Chéron, G.; Gauzit, R.; Fourgeaud, Jacques; L'Honneur, Anne Sophie; Tréluyer, Jean Marc; Charlier, Caroline; Casetta, Anne; Frange, Pierre; Leruez‐Ville, Marianne; Rozenberg, Flore; Lortholary, Olivier; Kernéis, Solen

doi:10.1093/cid/ciaa977

Cited by 28 publications

(24 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent study from a pediatric hospital in Chicago, revealed a low (1%‒2%) prevalence of SARS-CoV-2 among children without COVID-19 symptoms as well as no secondary transmission among HCWs exposed to those patients [ 14 ]. Another study, comparing the dynamics and determinants of SARS-CoV-2 transmissions among HCWs of adult and pediatric settings in Paris, revealed a significantly lower attack rate in a pediatric setting (2.3% vs 3.2%, respectively) [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of IgG antibodies against SARS-CoV-2 among healthcare workers in a tertiary pediatric hospital in Poland

et al. 2021

View full text Add to dashboard Cite

Data on the prevalence of the SARS-CoV-2 antibody in healthcare workers (HCWs) is scarce, especially in pediatric settings. The purpose of this study was to evaluate SARS-CoV-2 IgG-positivity among HCWs of a tertiary pediatric hospital. In addition, follow-up of the serological response in the subgroup of seropositive HCWs was analysed, to gain some insight on the persistence of IgG antibodies to SARS-CoV-2. We performed a retrospective analysis of voluntary SARS-CoV-2 IgG testing, which was made available free of charge to HCWs of the Children’s Memorial Health Institute in Warsaw (Poland). Plasma samples were collected between July 1 and August 9, 2020, and tested using the Abbott SARS-CoV-2 IgG assay. Of 2,282 eligible participants, 1,879 (82.3%) HCWs volunteered to undergo testing. Sixteen HCWs tested positive for SARS-CoV-2 IgG, corresponding to a seroprevalence of 0.85%. Among seropositive HCWs, three HCWs had confirmed COVID-19. Nine (56.3%) of the seropositive HCWs reported neither symptoms nor unprotected contact with confirmed SARS-CoV-2 cases in the previous months. A decline in the IgG index was observed at a median time of 86.5 days (range:84‒128 days) after symptom onset or RT-PCR testing. Further studies are necessary to elucidate the duration of persistence of anti-SARS-CoV-2 antibodies, as well as the correlation between seropositivity and protective immunity against reinfection. Regardless of the persistence of antibodies and their protective properties, such low prevalence indicates that this population is vulnerable to a second wave of the COVID-19 pandemic.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence of IgG antibodies against SARS-CoV-2 among healthcare workers in a tertiary pediatric hospital in Poland

et al. 2021

View full text Add to dashboard Cite

show abstract

“…This is in the 3.4% to 11.2% range described in other European surveys [10][11][12][13][14]. We estimated that the prevalence (inverse variance method with random effect) among French healthcare workers was 12.0% (CI 95, 7.0% to 19.0%), varying by the sampling method, and ranging from 7.0% when considering any healthcare workers to 12% among frontline caregivers, and 31.0% among symptomatic health professionals (Appendix D) [3,5,[15][16][17][18]. Such a variation in estimation highlights the need to identify subgroups at higher risk of infection.…”

Section: Discussionmentioning

confidence: 79%

“…Yet, the prevalence of the infection, including asymptomatic forms, in French healthcare workers remains poorly known. In small-sized studies, it was ranging from 2.2% in serologic screening among asymptomatic healthcare workers to 28% in RT-PCR among symptomatic healthcare workers [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Effect of Professional and Extra-Professional Exposure on Seroprevalence of SARS-CoV-2 Infection among Healthcare Workers of the French Alps: A Multicentric Cross-Sectional Study

Vitrat

Maillard

Raybaud³

et al. 2021

Vaccines

View full text Add to dashboard Cite

We aimed to report SARS-CoV-2 seroprevalence after the first wave of the pandemic among healthcare workers, and to explore factors associated with an increased infection rate. We conducted a multicentric cross-sectional survey from 27 June to 31 September 2020. For this survey, we enrolled 3454 voluntary healthcare workers across four participating hospitals, of which 83.4% were female, with a median age of 40.6 years old (31.8–50.3). We serologically screened the employees for SARS-CoV-2, estimated the prevalence of infection, and conducted binomial logistic regression with random effect on participating hospitals to investigate associations. We estimated the prevalence of SARS-CoV-2 infection at 5.0% (95 CI, 4.3%–5.8%). We found the lowest prevalence in health professional management support (4.3%) staff. Infections were more frequent in young professionals below 30 years old (aOR = 1.59, (95 CI, 1.06–2.37)), including paramedical students and residents (aOR = 3.38, (95 CI, 1.62–7.05)). In this group, SARS-CoV-2 prevalence was up 16.9%. The location of work and patient-facing role were not associated with increased infections. Employees reporting contacts with COVID-19 patients without adequate protective equipment had a higher rate of infection (aOR = 1.66, (95 CI, 1.12–2.44)). Aerosol-generating tasks were associated with a ~1.7-fold rate of infection, regardless of the uptake of FFP2. Those exposed to clusters of infected colleagues (aOR = 1.77, (95 CI, 1.24–2.53)) or intra-familial COVID-19 relatives (aOR = 2.09, (95 CI, 1.15–3.80)) also had a higher likelihood of infection. This report highlights that a sustained availability of personal protective equipment limits the SARS-CoV-2 infection rate to what is measured in the general population. It also pinpoints the need for dedicated hygiene training among young professionals, justifies the systematic eviction of infected personnel, and stresses the need for interventions to increase vaccination coverage among any healthcare workers.

show abstract

“…The recent study from pediatric hospital in Chicago, revealed a low (1-2 %) prevalence of SARS-CoV-2 among children without COVID-19 symptoms as well as no secondary transmission among HCWs exposed to these patients [14]. Another study, comparing dynamics and determinants of SARS-CoV-2 transmissions among HCWs of adult and pediatric settings in Paris, revealed significantly lower attack rate in the pediatric setting (2.3% vs 3.2%, respectively) [15].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of IgG antibodies against SARS-CoV-2 among healthcare workers in a tertiary pediatric hospital in Poland

Kasztelewicz

Janiszewska

Burzyńska

et al. 2020

Preprint

View full text Add to dashboard Cite

Data on prevalence of SARS-CoV-2 antibody in healthcare workers (HCWs) is scare, especially in pediatric settings. The purpose of this study was to evaluate the SARS-CoV-2 IgG-positivity among HCWs of a tertiary pediatric hospital. In addition, follow-up of serological response in the subgroup of seropositive HCWs was performed, to get some insight on persistence of IgG antibodies to SARS-CoV-2. Free, voluntary SARS-CoV-2 IgG testing was made available to HCWs of the Children’s Memorial Health Institute in Warsaw (Poland). Plasma samples were collected between July 1 and August 9, 2020 and tested using the Abbott SARS-CoV-2 IgG assay. Of 2282 eligible participants, 1879 (82.3%) HCWs volunteered to undergo testing. Sixteen HCWs tested positive for SARS-CoV-2 IgG, corresponding to the seroprevalence of 0.85%. Among seropositive HCWs, three had confirmed COVID-19. Of note, 8 (50%) seropositive HCWs reported neither symptoms nor unprotected contact with confirmed SARS-CoV-2 cases in the previous months. A decline in the IgG index was observed at median time of 86.5 days (range:84-128 days) after symptom onset or RT-PCR testing. The nationwide public health response measures together with infection prevention and control practices implemented at the hospital level, at the beginning of the COVID-19 pandemic, might explain a low seroprevalence. Further studies are warranted to elucidate the duration of anti-SARS-CoV-2 antibodies, as well as the correlation between seropositivity and protective immunity against reinfection. Regardless of the persistence of antibodies and their protective properties, such low prevalence indicates that this population is vulnerable to a second wave of the COVID-19 pandemic.

show abstract

Comparing Dynamics and Determinants of Severe Acute Respiratory Syndrome Coronavirus 2 Transmissions Among Healthcare Workers of Adult and Pediatric Settings in Central Paris

Cited by 28 publications

References 20 publications

Prevalence of IgG antibodies against SARS-CoV-2 among healthcare workers in a tertiary pediatric hospital in Poland

Prevalence of IgG antibodies against SARS-CoV-2 among healthcare workers in a tertiary pediatric hospital in Poland

Effect of Professional and Extra-Professional Exposure on Seroprevalence of SARS-CoV-2 Infection among Healthcare Workers of the French Alps: A Multicentric Cross-Sectional Study

Prevalence of IgG antibodies against SARS-CoV-2 among healthcare workers in a tertiary pediatric hospital in Poland

Contact Info

Product

Resources

About